Anti-phospholipase A2 receptor antibody positive hepatitis B virus-associated membranous nephropathy remitted with entecavir after relapse with lamivudine

2017 ◽  
Vol 7 (2) ◽  
pp. 93-97 ◽  
Author(s):  
Yosuke Sasaki ◽  
Yohko Nagai ◽  
Tetsuo Mikami ◽  
Yoshikiyo Akasaka ◽  
Kazutoshi Shibuya ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor ◽  
B Virus

Renal Phospholipase A2 Receptor in Hepatitis B Virus-Associated Membranous Nephropathy

2015 ◽  
Vol 41 (4-5) ◽  
pp. 345-353 ◽  
Author(s):  
Qionghong Xie ◽  
Yan Li ◽  
Jun Xue ◽  
Zuquan Xiong ◽  
Liang Wang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Class V ◽  
Primary Glomerulonephritis ◽  
Capillary Loop ◽  
Phospholipase A2 Receptor ◽  
Secondary Membranous Nephropathy ◽  
B Virus

Objective: This study examined the expression of renal phospholipase A2 receptor (PLA2R) in idiopathic and secondary membranous nephropathy (MN). Methods: Patients with biopsy-proven MN and non-MN were enrolled. Renal PLA2R was examined using an anti-PLA2R antibody (anti-PLA2R-Ab), and circulating PLA2R-Ab was detected by indirect immunofluorescence. Results: Renal PLA2R was detected along the capillary loop in 84% patients with idiopathic MN but not in those with any other primary glomerulonephritis. Only 1 of 38 patients with class V lupus nephritis showed renal PLA2R positive. In hepatitis B virus-associated MN (HBV-MN), 64% showed renal PLA2R positive, and PLA2R overlapped with HBsAg along the capillary loop. In addition, renal PLA2R positivity was closely associated with serum PLA2R-Ab. Renal PLA2R positive was present in all the patients with serum PLA2R-Ab positive and in 53% of patients with serum PLA2R-Ab negative. However, in patients with renal PLA2R negative, serum PLA2R-Ab was all negative. Conclusion: Renal biopsy PLA2R positivity was common in idiopathic MN and HBV-MN but rare in lupus-associated MN, and it was closely associated with serum PLA2R-Ab production. Further studies examining the association between PLA2R and HBV-MN may shed light on the mechanism of idiopathic MN or HBV-MN.

scholarly journals Expression of Phospholipase A2 Receptor in Pediatric Hepatitis B Virus-Related Membranous Nephropathy

2020 ◽  
Vol 24 (1) ◽  
pp. 36-41
Author(s):  
Sung-Eun Choi ◽  
Yoon Sung Bae ◽  
Keum Hwa Lee ◽  
Jae Il Shin ◽  
Hyeon Joo Jeong ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Phospholipase A2 ◽  
Membranous Nephropathy ◽  
Phospholipase A2 Receptor ◽  
B Virus

Steroid treatment in patients with membranous nephropathy and hepatitis B virus surface antigenemia: a report of two cases

2010 ◽  
Vol 15 (2) ◽  
pp. 289-293 ◽  
Author(s):  
Tetsu Akimoto ◽  
Toshiya Otake ◽  
Akira Tanaka ◽  
Hideaki Takahashi ◽  
Toshihiko Higashizawa ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Membranous Nephropathy ◽  
Steroid Treatment ◽  
Virus Surface ◽  
B Virus

scholarly journals Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy

2018 ◽  
Vol 37 (3) ◽  
pp. 248-256 ◽  
Author(s):  
Eun Joo Song ◽  
Kye Hwa Jeong ◽  
Young Ae Yang ◽  
Jeong-Hoon Lim ◽  
Hee-Yeon Jung ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Prognostic Marker ◽  
Membranous Nephropathy ◽  
Receptor Antibody ◽  
Phospholipase A2 Receptor

A higher frequency of IL-10-producing B cells in Hepatitis B virus-associated membranous nephropathy

2016 ◽  
Vol 43 (4) ◽  
pp. 417-427 ◽  
Author(s):  
Yong Liu ◽  
Haifeng Wang ◽  
Xintong Hu ◽  
Zhihui Qu ◽  
Huimao Zhang ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
B Cells ◽  
Hepatitis B ◽  
Membranous Nephropathy ◽  
B Virus
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