Test Method for Maleic Acid in Maleic Anhydride by Potentiometric Titration

10.1520/d2930 ◽  
2012 ◽  
Author(s):  
Keyword(s):  
Maleic Anhydride ◽  
Potentiometric Titration ◽  
Maleic Acid ◽  
Test Method

Synthesis and ethylene-promoted metathesis of adducts of tandem [4+2]/[4+2] cycloaddition between bis-furyl dienes and maleic acid derivatives

2021 ◽  
Vol 45 (7) ◽  
pp. 3400-3407
Author(s):  
Elizaveta A. Kvyatkovskaya ◽  
Polina P. Epifanova ◽  
Eugeniya V. Nikitina ◽  
Aleksey A. Senin ◽  
Victor N. Khrustalev ◽  
...  
Keyword(s):  
Maleic Anhydride ◽  
Maleic Acid

A series of 1,4:5,8-diepoxynaphthalenes, annellated with carbo- and heterocycles, was synthesized based on the tandem intermolecular/intramolecular [4+2] cycloaddition of bis-furyl dienes with moderately to highly reactive cyclic dienophiles (maleic anhydride and maleinimides).

Bulk Solution Assay Test Procedure Development and validation for Esomeprazole Sodium Injection 40mg as a CPP

2021 ◽  
pp. 177-192
Author(s):  
Santoshkumar R. Mulik ◽  
Rishikesh S. Bachhav
Keyword(s):  
Potentiometric Titration ◽  
Method Development ◽  
Uv Spectroscopy ◽  
Test Procedure ◽  
Processing Parameters ◽  
Test Method ◽  
Bulk Solution ◽  
Uv Spectrometry ◽  
Delayed Release ◽  
It Impact

Assay analytical test procedure at the Bulk-Solution stage for Esomeprazole Sodium Injection 40mgas a Critical Processing Parameters during manufacturing developed and validated. As per current available literature and the references, Esomeprazole active substance is available in market in the five forms, i.e. Esomeprazole as Plain [Tablet]; Esomeprazole Magnesium Trihydrate [Tablet, Capsule Delayed Release]; Esomeprazole Potassium [Tablet and Capsule]; Esomeprazole Strontium [Capsule Delayed Release] and Esomeprazole Sodium [Injectable].Assay test procedure for Active and other dosage forms [Tablet, Capsule] were available based on either Potentiometric Titration or HPLC basis. Product Esomeprazole Sodium Injection 40mg is not available in official pharmacopeia. As per available reference and literature assay test method for intermediate testing and finished product is based on HPLC. Intermediate testing [In-Process Testing] required as Critical Process Parameters [CPP] to ensure the quality i.e. appropriate bulk-solution purity, before to proceed for filtration and filling of Bulk-solution in unit dosage form [Vials]. To test the bulk solution purity approximate 5-6 hours required by HPLC. Which leads to hold the Bulk solution, further it impact and may risk to Bio-Burden of bulk solution. Also it impact and reduce the productivity of line by 5-6 hours. HPLC testing required special skilled manpower and cost. Considering all above concerns Study carried for test method development based on UV-Spectroscopy, HPLC and potentiometric titration. Based on method validation performed for UV-Spectrometry, HPLC and potentiometric titration; Test procedure developed and validated based on UV-Spectrometry is found Simple, Accurate, Precise, Economical and Rapid to save time and cost with increase in productivity as a Critical Processing Parameters for Esomeprazole Sodium Injection 40mgat the Bulk-Solution stage during manufacturing.

The Irritating Effects of Maleic Acid and of Maleic Anhydride upon the Eyes of Rabbits*

1950 ◽  
Vol 33 (3) ◽  
pp. 387-388 ◽  
Author(s):  
Charles A. Winter ◽  
E. Jane Tullius
Keyword(s):  
Maleic Anhydride ◽  
Maleic Acid

Interfaces in Alfa Fibre-Polypropylene Matrix Composites

2008 ◽  
Vol 587-588 ◽  
pp. 227-231
Author(s):  
M.C. Paiva ◽  
Anissa El Gaied ◽  
R.Ben Cheikh ◽  
António M. Cunha
Keyword(s):  
Maleic Anhydride ◽  
Plasma Treatment ◽  
Test Method ◽  
Matrix Composites ◽  
Air Plasma ◽  
Fragmentation Test ◽  
Characterization Studies ◽  
Polypropylene Matrix ◽  
Air Plasma Treatment ◽  
Fibre Matrix

Model composites with Polypropylene (PP) as matrix and alfa fibres (cellulose-based fibres obtained from the esparto grass of the subsaarian dry regions of Tunisia) were prepared for fibre/matrix interfacial characterization studies. The matrices tested were PP and PP combined with PP modified with maleic anhydride (PP-g-MA). The surface of the alfa fibres was treated by air plasma treatment. The adhesion between the untreated and treated fibres and both matrices was studied using the fragmentation test method. Composites with 10% weight of fibres were prepared by melt extrusion and injection moulding, and the specimens obtained tested for tensile properties. The fracture surfaces of the composites, obtained at low temperature, were observed by scanning electron microscopy. The presence of a small concentration of maleic anhydride grafted to the polymer matrix was found to be of the utmost importance for the establishment of a good fibre/matrix interface. The air plasma treatment had a cleaning effect of the fibre’s surface.

Maleic Anhydride, Maleic Acid, and Fumaric Acid

2005 ◽  
Author(s):  
Joseph C. Burnett ◽  
Scott F. Mitchell ◽  
Michael J. Mummey
Keyword(s):  
Maleic Anhydride ◽  
Fumaric Acid ◽  
Maleic Acid

scholarly journals Potentiometric Titration Behavior of Maleic Acid-Methyl Vinyl Ether Copolymer

1975 ◽  
Vol 48 (1) ◽  
pp. 15-17
Author(s):  
Etsuo KOKUFUTA ◽  
Masakatsu ITO ◽  
Mitsuo HIRATA ◽  
Shinji IWAI
Keyword(s):  
Potentiometric Titration ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Acid Methyl ◽  
Methyl Vinyl Ether
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