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Author(s):  
Someshwar D. Mankar ◽  
Abhijit S. Navale ◽  
Suraj R. Kadam

Nowadays Prescription Opioid Abuse has become a serious problem, to monitor and reduce Opioid Abuse most of countries developed Prescription Drug Monitoring Program (PDMP). Regarding to this we conduct a systematic review to understanding the PDMP impact in order to reduce Opioid Abuse and improving prescriber practices. This review can help to guide efforts to better response to the Opioid crises.


Author(s):  
Ana Catarina Viana Valle ◽  
Aloísio Cunha de Carvalho

Hepatocellular carcinoma (HCC) is the most common liver neoplasm in dogs and can be treated by the Viscum album therapy in a curative or palliative way. The objective is to report a hepatocellular carcinoma case in a dog treated by homeopathic therapy, extending to Palliative Care, with a 24-month survival. A 12-year-old Schnauzer male with a history of a liver nodule was treated by intravenous and subcutaneous applications of V. album in different dynamization and combinations, chromotherapy, and oral homeopathic medicines. The tumor growth was controlled, and the health condition of the patient was stable while the medication was given as prescribed. However, as application frequency was reduced, tumor growth increased, and health deterioration was verified. Nevertheless and contrary to expectations, the patient had a 24-month survival. Therefore, these findings point to the potential of V. album on enhancing the quality of life, controlling tumor growth, and prolonging survival on patients with HCC. Patients under continuous treatment would benefit better of these properties.


Author(s):  
Dattaprasad N. Vikhe

The immunity and system functions to fight against infections square measure considerably wedged by inappropriate food and nutrition. Long run deficiency disease is universally thought-about because the leading explanation for system deficiency. A considerable proportion of the worldwide population doesn't meet the counselled daily intake of nutrient. The COVID-19 pandemic has targeted attention on the role of the system, with health scientists and nutritionists urging folks to require supplements and/or eat specific foods (nutrients) to super-charge their immune systems. The system is that the most complicated system of physical structure. For this we have a tendency to needed the supplements like food for maintenance of system.in this article here could be a discussion of foods like Citrus fruits like lemon, orange, lime etc., broccoli, spinach, turmeric, yoghurt, kiwi, garlic, papaya, almonds, ginger, tulsi, etc things helps in boosting our immunity to fight against infections. In this report, foods that helps in maintain system or immunity boosting material is mentioned.


Author(s):  
Priyanka K. Shinde ◽  
Dattaprasad N. Vikhe ◽  
Ravindra S. Jadhav ◽  
Ganesh S. Shinde

The unknown coronavirus has been unfold all over within the world. The primary case was declared in Dec 2019, and this coronavirus malady has become a virulent disease. Infection of this virus is directly attacked on the system of the flesh or animals. Nowdays there’s a deficiency of correct management or vaccinum out there to stop this malady that principally attacks the system of body. Hindrance is healthier than cure. This term is extremely renowned to any or all people. Thus currently this time has come back to used for our savings of lives. Ayurveda is the ancient system of drugs which is originated in India. During this covid -19 amount boosting of our system is that the excellent thanks to fight against this corona virus. Many seasoning plants unit accessible in our shut that unit used for immunity boosting throughout Covid 19. Some seasoning plants like Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis that unit commonly used for immunity boosting. This herb contains compounds like glycosides, steroids, diterpenoid lactones, alkaloids, steroidal lactone,etc. vary of research unit accessible on Tinospora cordifolia, Ashwagandha, and Nyctanthes arbortristis to prove its immunomodulatory activity, anti-oxidant activity, anti- inflammatory activity, anti-pyretic activity. Throughout this general review we’ve a bent to targated on the role, drugs activities of Tinospora cordifolia, Withania somnifera, Nyctanthes arbortristis to prevention and treatment of COVID 19 or CORANA VIRUS infection.


Author(s):  
Mahesh. B. Chavan ◽  
Durgesh Tarade ◽  
Kushan. H. Pagare ◽  
Ritik. S. Jain

Coronavirus disease also termed as covid-19 or SARS-COV-2 infection has been declared as global pandemic disease by World Health Organization (WHO). The first case of covid-19 is reported at the local Huanan Seafood wholesale market in Wuhan city in Hubei in central chain at last of 2019. Covid-19 is rapidly spread throughout the world since December – 2019 from Wuhan city of China. Covid-19 patient has various symptoms like fever, cough, sore throat, breathlessness, fatigue and others. It is very necessary to identify the cases of covid-19 as soon as possible and isolate the suspected people and confirmed cases of Covid-19 to prevent the infection to other peoples.


Author(s):  
Habeeba S Shaikh ◽  
Ravindra S Jadhav ◽  
Dattaprasad N Vikhe

Nature has provide a medicinal agents since, for thousands of years and a impressive number of modern medicines. The medicines are isolated from natural sources; several supported their use in ancient medication. Higher plants, as sources of medicinal compounds, have continuing to play a dominant role in the upkeep of human health since ancient times. Over five hundredth of all trendy clinical medicine area units of natural product origin and play an necessary role in drug development programs in the pharmaceutical industry. Bauhinia racemosa Lam. are the plant which is broadly distributed in tropical climate regions. Bauhinia species are flowering trees found in Caesalpiniaceae family. The root and stem bark fibers which possesses curative properties. Ethnopharmacologically, varied elements of the plant starting from the bark of the plant to the gum obtained has been used in diseases like, Diarrhea, dysentery, fever etc. B. racemosa have the different photochemical constituents like flavonoids, glycosides, phenols, saponins, and tannins. several pharmacological actions of the plant already proved, that embrace anti-microbial, anthelmintic, antitumor activity. This review focus on the pharmacological actions and phytoconstituets of Bauhinia racemosa.


Author(s):  
Snehal Lad ◽  
Priya S. Rao ◽  
Dattaprasad N Vikhe

Calotropis gigantea plant has a family Asclepiadaceae commonly and sub family Apocynaceae known as Madar in Hindi. It is a perennial herb with a very long history of use in traditional medicines. Calotropis gigantea is a hoary, laticiferous shrub, which is also known as “the milkweed”. Calotropis is used as a traditional medicinal plant in whole world. Calotropis gigantea plant contain chemical constituents in which cardenolides, flavonoids, terpenes, pregnanes and nonprotein amino acid and more in various concentration. The root bark contains α-amyrin, β-amyrin, taraxasterol and its ψ-isomer taraxasteryl isovalerate, taraxasteryl acetate, gigantin, giganteol, isogiganteol, β-sitosterol and wax. The rootalso shows Nootropic activity in methanolic extract. The latex, leaves, flowers and bark are used as caustic, acrid, expectorant, to removes body hairs, anthelmintics and alsoused in leprosy, ulceration, cough, scabies ring worm of the scalp, piles, explosion on the body, asthma, enlargement of spleen or liver, edema and in painful joint swellings. Also, evaluate possible anxiogenic effect, sedative action and anxiolytic potential of crude ethanolic extract of Calotropis gigantealeaf. Methanolic extract of Calotropis gigantea root used as memory increasing activity. This review gives an idea about its pharmacological activity and phytochemistry.


Author(s):  
Santoshkumar R. Mulik ◽  
Rishikesh S. Bachhav

Assay analytical test procedure at the Bulk-Solution stage for Esomeprazole Sodium Injection 40mgas a Critical Processing Parameters during manufacturing developed and validated. As per current available literature and the references, Esomeprazole active substance is available in market in the five forms, i.e. Esomeprazole as Plain [Tablet]; Esomeprazole Magnesium Trihydrate [Tablet, Capsule Delayed Release]; Esomeprazole Potassium [Tablet and Capsule]; Esomeprazole Strontium [Capsule Delayed Release] and Esomeprazole Sodium [Injectable].Assay test procedure for Active and other dosage forms [Tablet, Capsule] were available based on either Potentiometric Titration or HPLC basis. Product Esomeprazole Sodium Injection 40mg is not available in official pharmacopeia. As per available reference and literature assay test method for intermediate testing and finished product is based on HPLC. Intermediate testing [In-Process Testing] required as Critical Process Parameters [CPP] to ensure the quality i.e. appropriate bulk-solution purity, before to proceed for filtration and filling of Bulk-solution in unit dosage form [Vials]. To test the bulk solution purity approximate 5-6 hours required by HPLC. Which leads to hold the Bulk solution, further it impact and may risk to Bio-Burden of bulk solution. Also it impact and reduce the productivity of line by 5-6 hours. HPLC testing required special skilled manpower and cost. Considering all above concerns Study carried for test method development based on UV-Spectroscopy, HPLC and potentiometric titration. Based on method validation performed for UV-Spectrometry, HPLC and potentiometric titration; Test procedure developed and validated based on UV-Spectrometry is found Simple, Accurate, Precise, Economical and Rapid to save time and cost with increase in productivity as a Critical Processing Parameters for Esomeprazole Sodium Injection 40mgat the Bulk-Solution stage during manufacturing.


Author(s):  
Swamini A Dighe ◽  
Suhas S Siddheshwar ◽  
Ganesh S Shinde

Venlafaxine HCl is one of the antidepressant agent which comes under the category of serotonin-norepinephrine reuptake inhibitor i.e SNRI. This medication is usually used to treat major depressive disorder in adult. It may help to improve the mood and energy level and also to regain the interest in daily activities in the depressed person. The present review focus on various approaches for the analysis on Venlafaxine in bulk and pharmaceutical dosage forms. The review represents the various analytical method like the RP-HPLC, HPTLC, UV Spectroscopy and Stability Indicating Methods which were used for the investigation of Venlafaxine in bulk and different dosage formulations.


Author(s):  
Rutuja S Nalkar ◽  
Suhas S Siddheshwar ◽  
Mahesh H Kolhe

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy & bipolar disorder/major affective disorder (manic depression). Lamotrigine is and antiepileptic drug of phenyltriazine class. For epilepsy it is used to treat the partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with the Lennox-Gastuat syndrome and are chemically unrelated to the other anticonvulsants. Lamotrigine is a phenyltriazine that has comparatively few side-effects and it does not requires blood monitoring/observance in monotherapy. It additionally acts as a mood stabilizer. Common side-effects of lamotrigine include, nausea, sleepiness, headache, vomiting, trouble/bother with co-ordination and rash. Serious side-effects include in, lack of red blood cells, accumulated in risk of suicide, Stevens-Johnson syndrome and allergy. It issues that use of lamotrigine throughout pregnancy or breastfeeding it’s going to lead/result in harm/damage.


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