Guide for Pre-clinical in vivo Evaluation in Critical Size Segmental Bone Defects

2009 ◽  
Author(s):  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
In Vivo Evaluation ◽  
Segmental Bone ◽  
Segmental Bone Defects

scholarly journals Regenerating Critical Size Rat Segmental Bone Defects with a Self‐Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP‐2 Incorporation

2021 ◽  
pp. 2100088
Author(s):  
Claire I. A. Houdt ◽  
Marianne K. E. Koolen ◽  
Paula M. Lopez‐Perez ◽  
Dietmar J. O. Ulrich ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
Self Healing ◽  
Nanocomposite Hydrogel ◽  
Hybrid Nanocomposite ◽  
Segmental Bone ◽  
Bone Condition ◽  
Segmental Bone Defects

The association of human mesenchymal stem cells with BMP-7 improves bone regeneration of critical-size segmental bone defects in athymic rats

Bone ◽  
2010 ◽  
Vol 47 (1) ◽  
pp. 117-126 ◽  
Author(s):  
Giorgio Burastero ◽  
Sonia Scarfì ◽  
Chiara Ferraris ◽  
Chiara Fresia ◽  
Nadia Sessarego ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bone Regeneration ◽  
Critical Size ◽  
Human Mesenchymal Stem Cells ◽  
Bone Defects ◽  
Segmental Bone ◽  
Segmental Bone Defects

scholarly journals Development of Composite Scaffolds for Load-Bearing Segmental Bone Defects

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Marcello Pilia ◽  
Teja Guda ◽  
Mark Appleford
Keyword(s):  
Composite Scaffold ◽  
Polymeric Materials ◽  
Bone Defects ◽  
Anatomical Location ◽  
Composite Scaffolds ◽  
Load Bearing ◽  
Composite Grafts ◽  
Segmental Bone ◽  
Segmental Bone Defects

The need for a suitable tissue-engineered scaffold that can be used to heal load-bearing segmental bone defects (SBDs) is both immediate and increasing. During the past 30 years, various ceramic and polymer scaffolds have been investigated for this application. More recently, while composite scaffolds built using a combination of ceramics and polymeric materials are being investigated in a greater number, very few products have progressed from laboratory benchtop studies to preclinical testing in animals. This review is based on an exhaustive literature search of various composite scaffolds designed to serve as bone regenerative therapies. We analyzed the benefits and drawbacks of different composite scaffold manufacturing techniques, the properties of commonly used ceramics and polymers, and the properties of currently investigated synthetic composite grafts. To follow, a comprehensive review ofin vivomodels used to test composite scaffolds in SBDs is detailed to serve as a guide to design appropriate translational studies and to identify the challenges that need to be overcome in scaffold design for successful translation. This includes selecting the animal type, determining the anatomical location within the animals, choosing the correct study duration, and finally, an overview of scaffold performance assessment.

Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4

2004 ◽  
Vol 6 (9) ◽  
pp. 984-991 ◽  
Author(s):  
Hsain-Chung Shen ◽  
Hairong Peng ◽  
Arvydas Usas ◽  
Brian Gearhart ◽  
Freddie H. Fu ◽  
...  
Keyword(s):  
Critical Size ◽  
Bone Defects ◽  
Segmental Bone ◽  
Segmental Bone Defects

scholarly journals Novel osteoinductive photo-cross-linkable chitosan-lactide-fibrinogen hydrogels enhance bone regeneration in critical size segmental bone defects

2014 ◽  
Vol 10 (12) ◽  
pp. 5021-5033 ◽  
Author(s):  
Sungwoo Kim ◽  
Katherine Bedigrew ◽  
Teja Guda ◽  
William J. Maloney ◽  
Sangwon Park ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Critical Size ◽  
Bone Defects ◽  
Segmental Bone ◽  
Segmental Bone Defects
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