Zoonotic Transmission and Host Switches of Malaria Parasites

Malaria is a deadly disease that affects the health of hundreds of millions of people annually. Five Plasmodium parasite species naturally infect humans: Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, and Plasmodium knowlesi. These parasites can also infect various non-human primates. Parasites mainly infecting monkeys, such as Plasmodium cynomolgi and P. knowlesi, the latter of which was considered to be a monkey parasite for years, can also be transmitted to human hosts. Recently, many new Plasmodium species have been discovered in African apes, some of which may be transmitted to humans in the future. Here, we searched PubMed and the internet via Google and selected articles on the zoonotic transmission and evolution of selected malaria parasite species. We review current advances in the relevant topics, emphasizing the transmission of malaria parasites between humans and non-human primates. We also briefly discuss the transmission of some avian malaria parasites between wild birds and domestic fowls. Zoonotic malaria transmission is widespread, thus posing a threat to public health. More studies on parasite species, including their identification in non-human primates, transmission, and evolution, are needed to decrease or prevent the transmission of malaria parasites from non-human primates to humans.

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Host Specialization and Geographic Localization of Avian Malaria Parasites: A Regional Analysis in the Lesser Antilles

The American Naturalist ◽

10.2307/3473476 ◽

2005 ◽

Vol 165 (4) ◽

pp. 466

Author(s):

Fallon ◽

Bermingham ◽

Ricklefs

Keyword(s):

Avian Malaria ◽

Regional Analysis ◽

Host Specialization ◽

Lesser Antilles ◽

Malaria Parasites ◽

Avian Malaria Parasites

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Non-human primate and human malaria: past, present and future

Journal of Travel Medicine ◽

10.1093/jtm/taab036 ◽

2021 ◽

Author(s):

Spinello Antinori ◽

Cecilia Bonazzetti ◽

Andrea Giacomelli ◽

Mario Corbellino ◽

Massimo Galli ◽

...

Keyword(s):

Plasmodium Knowlesi ◽

Plasmodium Species ◽

Molecular Techniques ◽

Malaria Parasites ◽

Human Malaria ◽

Complex Interactions ◽

Zoonotic Malaria ◽

The Impact ◽

Human Plasmodium ◽

Human Primate

Abstract Background Studies of the malaria parasites infecting various non-human primates (NHPs) have increased our understanding of the origin, biology and pathogenesis of human Plasmodium parasites. This review considers the major discoveries concerning NHP malaria parasites, highlights their relationships with human malaria and considers the impact that this may have on attempts to eradicate the disease. Results The first description of NHP malaria parasites dates back to the early 20th century. Subsequently, experimental and fortuitous findings indicating that some NHP malaria parasites can be transmitted to humans have raised concerns about the possible impact of a zoonotic malaria reservoir on efforts to control human malaria. Advances in molecular techniques over the last 15 years have contributed greatly to our knowledge of the existence and geographical distribution of numerous Plasmodium species infecting NHPs, and extended our understanding of their close phylogenetic relationships with human malaria parasites. The clinical application of such techniques has also made it possible to document ongoing spillovers of NHP malaria parasites (Plasmodium knowlesi, P. cynomolgi, P. simium, P. brasilianum) in humans living in or near the forests of Asia and South America, thus confirming that zoonotic malaria can undermine efforts to eradicate human malaria. Conclusions Increasing molecular research supports the prophetic intuition of the pioneers of modern malariology who saw zoonotic malaria as a potential obstacle to the full success of malaria eradication programmes. It is, therefore, important to continue surveillance and research based on one-health approaches in order to improve our understanding of the complex interactions between NHPs, mosquito vectors and humans during a period of ongoing changes in the climate and the use of land, monitor the evolution of zoonotic malaria, identify the populations most at risk and implement appropriate preventive strategies.

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Assessing Diversity, Plasmodium Infection and Blood Meal Sources in Mosquitoes (Diptera: Culicidae) from a Brazilian Zoological Park with Avian Malaria Transmission

Insects ◽

10.3390/insects12030215 ◽

2021 ◽

Vol 12 (3) ◽

pp. 215

Author(s):

Lilian de Oliveira Guimarães ◽

Roseli França Simões ◽

Carolina Romeiro Fernandes Chagas ◽

Regiane Maria Tironi de Menezes ◽

Fabiana Santos Silva ◽

...

Keyword(s):

Blood Meal ◽

Avian Malaria ◽

Mosquito Species ◽

Plasmodium Species ◽

Sao Paulo ◽

São Paulo ◽

Malaria Parasites ◽

Ecological Relationships ◽

Lack Of Information ◽

Avian Malaria Parasites

Avian malaria parasites are widespread parasites transmitted by Culicidae insects belonging to different genera. Even though several studies have been conducted recently, there is still a lack of information about potential vectors of Plasmodium parasites, especially in Neotropical regions. Former studies with free-living and captive animals in São Paulo Zoo showed the presence of several Plasmodium and Haemoproteus species. In 2015, a pilot study was conducted at the zoo to collect mosquitoes in order to find out (i) which species of Culicidae are present in the study area, (ii) what are their blood meal sources, and (iii) to which Plasmodium species might they be potential vectors. Mosquitoes were morphologically and molecularly identified. Blood meal source and haemosporidian DNA were identified using molecular protocols. A total of 25 Culicidae species were identified, and 6 of them were positive for Plasmodium/Haemoproteus DNA. Ten mosquito species had their source of blood meal identified, which were mainly birds, including some species that were positive for haemosporidian parasites in the former study mentioned. This study allowed us to expand the list of potential vectors of avian malaria parasites and to improve our knowledge of the evolutionary and ecological relationships between the highly diverse communities of birds, parasites, and vectors present at São Paulo Zoo.

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