scholarly journals Evaluation of metrological characteristics of spectral analysis method for determining erythrocyte morphology

2021 ◽  
pp. 45-49
Author(s):  
Ye. I. Sokol ◽  
K. V. Kolisnyk ◽  
T. V. Bernads’ka
Keyword(s):  
Spectral Analysis ◽  
Clinical Laboratory ◽  
Geometric Parameters ◽  
Metrological Characteristics ◽  
Image Correlation ◽  
Optical Methods ◽  
Laboratory Diagnostics ◽  
Erythrocyte Morphology ◽  
Diagnostic Characteristics ◽  
Spectral Photometry

Spectral photometry is currently widely used for quantitative and qualitative analysis of biological molecules in medical biology. The method is based on the ability of molecules to absorb electromagnetic radiation. Modern clinical laboratory diagnostics extensively uses optical methods of analysis that rely on these physical properties of semitransparent objects, such as blood components. Knowing the absorption spectra of blood and its components, it is possible to quantify the concentration of all the components by solving the mathematical system of equations corresponding to these spectra. However, the existing methods of optical analysis of erythrocytes do not allow quantifying their geometric parameters, which may also indicate certain diagnostic signs and be used to analyze the clinical condition of the patient's body. The aim of this work is to evaluate the metrological characteristics of the newly developed method of determining the geometric parameters of erythrocytes, which combines spectral analysis and double annealing. The input data for the 3D imaging of erythrocytes were taken from the images of the sample both made in natural light and illuminated by a coherent light source with different wavelengths. The latter, after some additional image correlation, increases the reliability of the result. The calculation results on the errors and the measuring channel resolution of the digital interference microscope indicate an acceptable accuracy of the method. The accuracy of the three-dimensional image obtained by the proposed method is more than 20% higher than that of other known methods. This allows determining the informative geometric parameters of the structure of erythrocytes more accurately and using them to obtain additional clinical diagnostic characteristics of the patient's body.

The Use of Modan 3D in Experimental Modal Analysis

2013 ◽  
Vol 486 ◽  
pp. 36-41 ◽  
Author(s):  
Róbert Huňady ◽  
František Trebuňa ◽  
Martin Hagara ◽  
Martin Schrötter
Keyword(s):  
Modal Analysis ◽  
Vibration Analysis ◽  
High Speed ◽  
Mechanical Vibration ◽  
Steel Sample ◽  
Experimental Modal Analysis ◽  
Image Correlation ◽  
Optical Methods ◽  
Mode Shapes ◽  
Vibration Modes

Experimental modal analysis is a relatively young part of dynamics, which deals with the vibration modes identification of machines or their parts. Its development has started since the beginning of the eighties, when the computers hardware equipment has improved and the fast Fourier transform (FFT) could be used for the results determination. Nowadays it provides an uncountable set of vibration analysis possibilities starting with conventional contact transducers of acceleration and ending with modern noncontact optical methods. In this contribution we mention the use of high-speed digital image correlation by experimental determination of mode shapes and modal frequencies. The aim of our work is to create a program application called Modan 3D enabling the performing of experimental modal analysis and operational modal analysis. In this paper the experimental modal analysis of a thin steel sample performed with Q-450 Dantec Dynamics is described. In Modan 3D the experiment data were processed and the vibration modes were determined. The reached results were verified by PULSE modulus specialized for mechanical vibration analysis.

Organization of the work of the medical laboratory service in accordance with the requirements of the standard GOST ISO 15189–2015 «Medical laboratories. Particular requirements for quality and competence»

2020 ◽  
pp. 15-22
Author(s):  
Elena Vitalievna Perminova
Keyword(s):  
Clinical Laboratory ◽  
Medical Laboratory ◽  
Laboratory Research ◽  
Laboratory Diagnostics ◽  
Clinical Diagnostic Laboratory ◽  
Diagnostic Laboratory ◽  
Iso 15189 ◽  
Laboratory Service ◽  
Medical Laboratories

Clinical laboratory diagnostics is a medical specialty, which is based on in vitro diagnostic studies of biomaterial obtained from an individual. At the present stage, there are three main types of organization of the laboratory research process — a laboratory service as part of a medical and preventive institution, a centralized laboratory where biomaterials are delivered for research from various healthcare institutions, as well as mobile laboratories that allow conducting the research directly at the patient’s bedside. This discipline involves the use of a wide variety of diagnostic research methods and the use of a huge number of specific techniques. Their list should include carrying out hematological, microbiological, virological, immunological, serological, parasitic, and biochemical studies. Also, when organizing laboratory diagnostic activities, a number of other studies (cytological, histological, toxicological, genetic, molecular biological, etc.) are provided. A laboratory report is formulated after obtaining clinical data and comparing them with the obtained test results. The quality of laboratory tests is ensured through the systematic implementation of internal laboratory control, as well as participation in a national program for external quality assessment. The activities of the clinical diagnostic laboratory should be organized in accordance with the requirements of the standard GOST R ISO 15189–2015 «Medical laboratories. Particular requirements for quality and competence», which is based on the provisions of two more fundamental standards — ISO 9001 and ISO 17025, and adds a number of special requirements related to medical laboratories.

scholarly journals Laboratory Diagnostics Performance in Uganda: A Survey of Test Availability and Constraints Across 100 Laboratories

2021 ◽  
Author(s):  
Noel Namuhani ◽  
Suzanne N Kiwanuka ◽  
Martha Akulume ◽  
Simeon Kalyesubula ◽  
William Bazeyo ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Disease Diagnosis ◽  
Sub Saharan Africa ◽  
Essential Medicines ◽  
Full Blood Count ◽  
Laboratory Diagnostics ◽  
Cross Sectional ◽  
Laboratory Services ◽  
Control And Prevention ◽  
Sub Saharan

Abstract Background Clinical laboratory services are a critical component of the health system for effective disease diagnosis, treatment, control and prevention. However, many laboratories in Sub Saharan Africa remain dysfunctional. The high costs of tests in the private sector also remain a hindrance to accessing testing services. This study aimed at assessing the functionality of laboratories based on test menus and the associated constraints in Uganda. Methods This cross sectional quantitative study involved an assessment of 100 laboratories randomly selected in 20 districts from four regions of the country. Sixteen percent of the studied laboratories were regional hub laboratories. Laboratory in charges and managers in each of the selected laboratories were interviewed. A checklist for laboratory supplies adapted from the Essential Medicines and Health supplies list for Uganda, (2012) was used to assess availability of testing supplies. Data was analyzed using excel and STATA 14. Results At the point of assessment, generally, all laboratories were able to perform malaria tests and HIV tests. All the hub laboratories conducted malaria tests and TB screening. Less than half had electrolytes tests due to lack of equipment, nonfunctioning equipment and lack of reagents. Full blood count tests were missing in 25% of the hub laboratories mainly due to lack of equipment. The lack of reagents (66.7%) and the lack of equipment (58.3%) caused the majority 10/16 of the hubs to routinely referred specimens for tests that are supposed to be carried out in these laboratories due to lack of reagents (66.7%) and non-functional equipment (58.3%). Although officially recognized as an operational structure, Hub laboratories lacked a list of essential and vital supplies. Conclusions Most laboratories performed well for the common tests. However, many laboratories did not meet testing requirements especially for the advanced tests according to standard testing menus for Uganda due to non-functioning equipment, lack of equipment and reagents. Hubs lack list of essential supplies. Therefore, there is need to provide equipment to laboratories, repair the non-functional ones and develop an essential list of supplies for the hub laboratories.

scholarly journals The actual aspects of the combination of theory and practice in the teaching of discipline «clinical laboratory diagnostics»

2019 ◽  
Vol 23 (1 (89)) ◽  
pp. 140-144 ◽  
Author(s):  
G. I. Kshanovska ◽  
L. D. Boreyko ◽  
I. A. Plesh ◽  
S. Yu. Karatieieva ◽  
N. А. Slyvka
Keyword(s):  
Clinical Laboratory ◽  
Theory And Practice ◽  
Laboratory Diagnostics
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