scholarly journals Ste20-like kinase is critical for inhibitory synapse maintenance and its deficiency confers a developmental dendritopathy

2021 ◽  
pp. JN-RM-0352-21
Author(s):  
Susanne Schoch ◽  
Anne Quatraccioni ◽  
Barbara K. Robens ◽  
Robert Maresch ◽  
Karen M.J. van Loo ◽  
...  
Keyword(s):  
Inhibitory Synapse ◽  
Synapse Maintenance

scholarly journals Ste20-like kinase is critical for inhibitory synapse maintenance and its deficiency confers a developmental dendritopathy

2020 ◽  
Author(s):  
Susanne Schoch ◽  
Anne Quatraccioni ◽  
Barbara K. Robens ◽  
Robert Maresch ◽  
Karen M.J. van Loo ◽  
...  
Keyword(s):  
Cortical Neurons ◽  
Neuronal Development ◽  
Significant Loss ◽  
Inhibitory Synapse ◽  
Inhibitory Synapses ◽  
Cytoskeletal Dynamics ◽  
Synapse Maintenance ◽  
Excitatory Neurotransmission ◽  
Dendritic Complexity ◽  
Dysmorphic Neurons

SummaryThe size and structure of the dendritic arbor play important roles in determining how synaptic inputs of neurons are converted to action potential output. The regulatory mechanisms governing the development of dendrites, however, are insufficiently understood. The evolutionary conserved Ste20/Hippo kinase pathway has been proposed to play an important role in regulating the formation and maintenance of dendritic architecture. A key element of this pathway, Ste20-like kinase (SLK), regulates cytoskeletal dynamics in non-neuronal cells and is strongly expressed throughout neuronal development. However, its function in neurons is unknown. We show that during development of mouse cortical neurons, SLK has a surprisingly specific role for proper elaboration of higher, ≥ 3rd, order dendrites. Moreover, we demonstrate that SLK is required to maintain excitation-inhibition balance. Specifically, SLK knockdown caused a selective loss of inhibitory synapses and functional inhibition after postnatal day 15, while excitatory neurotransmission was unaffected. Finally, we show that this mechanism may be relevant for human disease, as dysmorphic neurons within human cortical malformations revealed significant loss of SLK expression. Overall, the present data identify SLK as a key regulator of both dendritic complexity during development and of inhibitory synapse maintenance.

scholarly journals Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Martin H. Berryer ◽  
Bidisha Chattopadhyaya ◽  
Paul Xing ◽  
Ilse Riebe ◽  
Ciprian Bosoi ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Inhibitory Synapse ◽  
Synaptic Inhibition

scholarly journals Inhibitory synapse deficits caused by familial α1 GABAA receptor mutations in epilepsy

2017 ◽  
Vol 108 ◽  
pp. 213-224 ◽  
Author(s):  
Xiumin Chen ◽  
Nela Durisic ◽  
Joseph W. Lynch ◽  
Angelo Keramidas
Keyword(s):  
Gabaa Receptor ◽  
Inhibitory Synapse

An excitatory and inhibitory synapse ratio on cortical nonpyramidal cell subtypes of the rat

2007 ◽  
Vol 58 ◽  
pp. S74
Author(s):  
Akio Sekigawa ◽  
Yoshiyuki Kubota ◽  
Sayuri Hatada ◽  
Yasuo Kawaguchi
Keyword(s):  
Inhibitory Synapse

scholarly journals Electrolyte Gated Oxide Pseudodiode for Inhibitory Synapse Applications

2018 ◽  
Vol 4 (11) ◽  
pp. 1800371 ◽  
Author(s):  
Yang Ming Fu ◽  
Chang Jin Wan ◽  
Fei Yu ◽  
Hui Xiao ◽  
Jian Tao ◽  
...  
Keyword(s):  
Inhibitory Synapse

Differences in Input Space Stability Between Using the Inverted Output of Amplifier and Negative Conductance for Inhibitory Synapse

2007 ◽  
pp. 1015-1024
Author(s):  
Min-Jae Kang ◽  
Ho-Chan Kim ◽  
Wang-Cheol Song ◽  
Junghoon Lee ◽  
Hee-Sang Ko ◽  
...  
Keyword(s):  
Inhibitory Synapse ◽  
Input Space ◽  
Negative Conductance

Molecular diversity underlying cortical excitatory and inhibitory synapse development

2018 ◽  
Vol 53 ◽  
pp. 8-15 ◽  
Author(s):  
Emilia Favuzzi ◽  
Beatriz Rico
Keyword(s):  
Molecular Diversity ◽  
Inhibitory Synapse ◽  
Synapse Development

A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment

2020 ◽  
Vol 87 ◽  
pp. 106814
Author(s):  
Shu-ming Li ◽  
Bin Li ◽  
Ling Zhang ◽  
Guang-fen Zhang ◽  
Jie Sun ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Systemic Inflammation ◽  
Inhibitory Synapse ◽  
Related Protein ◽  
Protein Loss
Sign in / Sign up

Export Citation Format

Share Document