scholarly journals Uptake and Neuritic Transport of Scrapie Prion Protein Coincident with Infection of Neuronal Cells

2005 ◽  
Vol 25 (21) ◽  
pp. 5207-5216 ◽  
Author(s):  
A. C. Magalhaes
Keyword(s):  
Prion Protein ◽  
Neuronal Cells

scholarly journals The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

2007 ◽  
Vol 402 (1) ◽  
pp. 17-23 ◽  
Author(s):  
David R. Taylor ◽  
Nigel M. Hooper
Keyword(s):  
Prion Protein ◽  
Low Density Lipoprotein ◽  
Neuronal Cells ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Adaptor Protein ◽  
Cellular Prion Protein ◽  
Low Density ◽  
Related Protein ◽  
Density Lipoprotein Receptor

PrPC (cellular prion protein) is located at the surface of neuronal cells in detergent-insoluble lipid rafts, yet is internalized by clathrin-dependent endocytosis. As PrPC is glycosyl-phosphatidylinositol-anchored, it requires a transmembrane adaptor protein to connect it to the clathrin endocytosis machinery. Using receptor-associated protein and small interfering RNA against particular LDL (low-density lipoprotein) family members, in combination with immunofluorescence microscopy and surface biotinylation assays, we show that the transmembrane LRP1 (LDL receptor-related protein 1) is required for the Cu2+-mediated endocytosis of PrPC in neuronal cells. We show also that another LRP1 ligand that can cause neurodegenerative disease, the Alzheimer's amyloid precursor protein, does not modulate the endocytosis of PrPC.

Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells

2008 ◽  
Vol 86 (3) ◽  
pp. 653-659 ◽  
Author(s):  
Ingrid Dupiereux ◽  
Nandini Falisse-Poirrier ◽  
Willy Zorzi ◽  
Nicole T. Watt ◽  
Olivier Thellin ◽  
...  
Keyword(s):  
Protective Effect ◽  
Prion Protein ◽  
Neuronal Cells ◽  
Oxidative Injury ◽  
Terminal Region

Effect of Flupirtine on Bcl-2 and Glutathione Level in Neuronal Cells Treatedin Vitrowith the Prion Protein Fragment (PrP106-126)

1997 ◽  
Vol 147 (2) ◽  
pp. 518-524 ◽  
Author(s):  
Sanja Perovic ◽  
Heinz C. Schröder ◽  
Gabriela Pergande ◽  
Hiroshi Ushijima ◽  
Werner E.G. Müller
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Glutathione Level ◽  
Protein Fragment

scholarly journals FTY720 protects neuronal cells from damage induced by human prion protein by inactivating the JNK pathway

2013 ◽  
Vol 32 (6) ◽  
pp. 1387-1393 ◽  
Author(s):  
MYUNG-HEE MOON ◽  
JAE-KYO JEONG ◽  
YOU-JIN LEE ◽  
SANG-YOUEL PARK
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Jnk Pathway ◽  
Human Prion Protein

Proteomics Approach to Identify the Interacting Partners of Cellular Prion Protein and Characterization of Rab7a Interaction in Neuronal Cells

2011 ◽  
Vol 10 (7) ◽  
pp. 3123-3135 ◽  
Author(s):  
Saima Zafar ◽  
Nicolas von Ahsen ◽  
Michael Oellerich ◽  
Inga Zerr ◽  
Walter J. Schulz-Schaeffer ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Proteomics Approach

scholarly journals Peroxiredoxin 6 promotes upregulation of the prion protein (PrP) in neuronal cells of prion-infected mice

2012 ◽  
Vol 10 (1) ◽  
pp. 38 ◽  
Author(s):  
Wibke Wagner ◽  
Andreas Reuter ◽  
Petra Hüller ◽  
Johannes Löwer ◽  
Silja Wessler
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Peroxiredoxin 6

Cellular Prion Protein Signaling in Serotonergic Neuronal Cells

2007 ◽  
Vol 1096 (1) ◽  
pp. 106-119 ◽  
Author(s):  
S. MOUILLET-RICHARD ◽  
B. SCHNEIDER ◽  
E. PRADINES ◽  
M. PIETRI ◽  
M. ERMONVAL ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Cellular Prion Protein ◽  
Protein Signaling

scholarly journals Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis

2005 ◽  
Vol 280 (46) ◽  
pp. 38851-38861 ◽  
Author(s):  
Mark Kristiansen ◽  
Marcus J. Messenger ◽  
Peter-Christian Klöhn ◽  
Sebastian Brandner ◽  
Jonathan D. F. Wadsworth ◽  
...  
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Caspase Activation

scholarly journals Immunoseparation of Prion protein-enriched domains from other detergent-resistant membrane fractions, isolated from neuronal cells

FEBS Letters ◽  
2003 ◽  
Vol 557 (1-3) ◽  
pp. 143-147 ◽  
Author(s):  
Laura Botto ◽  
Massimo Masserini ◽  
Arianna Cassetti ◽  
Paola Palestini
Keyword(s):  
Prion Protein ◽  
Neuronal Cells ◽  
Detergent Resistant Membrane
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