Collagen VI regulates motor circuit plasticity and motor performance by cannabinoid modulation

Collagen VI is a key component of muscle basement membranes, and genetic variants can cause monogenic muscular dystrophies. Conversely, human genetic studies recently implicated collagen VI in central nervous system function, with variants causing the movement disorder dystonia. To elucidate the neurophysiological role of collagen VI, we generated mice with a truncation of the dystonia-related collagen α3 (VI) (COL6A3) C-terminal domain (CTD). These Col6a3CTT mice showed a recessive dystonia-like phenotype. We found that COL6A3 interacts with the cannabinoid receptor 1 (CB1R) complex in a CTD-dependent manner. Col6a3CTT mice have impaired homeostasis of excitatory input to the basal pontine nuclei (BPN), a motor control hub with dense COL6A3 expression, consistent with deficient endocannabinoid signaling. Aberrant synaptic input in the BPN was normalized by a CB1R agonist, and motor performance in Col6a3CTT mice was improved by CB1R agonist treatment. Our findings identify a readily therapeutically addressable synaptic mechanism for motor control.

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Improved Estimation of Induction Motor Circuit Parameters with Published Motor Performance Data

2014 Sixth Annual IEEE Green Technologies Conference ◽

10.1109/greentech.2014.18 ◽

2014 ◽

Cited By ~ 2

Author(s):

Gang Wang ◽

Sung-Won Park

Keyword(s):

Induction Motor ◽

Motor Performance ◽

Performance Data ◽

Motor Circuit

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The effect of knowledge of the desired outcome on dental motor performance

Journal of Dental Education ◽

10.1002/j.0022-0337.1988.52.4.tb02191.x ◽

1988 ◽

Vol 52 (4) ◽

pp. 198-201 ◽

Cited By ~ 6

Author(s):

PH Feil ◽

T Reed

Keyword(s):

Motor Performance

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Cognitive Load Affects Speech Motor Performance Differently in Older and Younger Adults

Journal of Speech Language and Hearing Research ◽

10.1044/2018_jslhr-s-17-0222 ◽

2019 ◽

Vol 62 (5) ◽

pp. 1258-1277 ◽

Cited By ~ 1

Author(s):

Megan K. MacPherson

Keyword(s):

Older Adults ◽

Cognitive Load ◽

Motor Performance ◽

Age Groups ◽

Incongruent Condition ◽

Sentence Production ◽

Movement Duration ◽

Production Task ◽

Younger Adults ◽

Speech Motor

PurposeThe aim of this study was to determine the impact of cognitive load imposed by a speech production task on the speech motor performance of healthy older and younger adults. Response inhibition, selective attention, and working memory were the primary cognitive processes of interest.MethodTwelve healthy older and 12 healthy younger adults produced multiple repetitions of 4 sentences containing an embedded Stroop task in 2 cognitive load conditions: congruent and incongruent. The incongruent condition, which required participants to suppress orthographic information to say the font colors in which color words were written, represented an increase in cognitive load relative to the congruent condition in which word text and font color matched. Kinematic measures of articulatory coordination variability and movement duration as well as a behavioral measure of sentence production accuracy were compared between groups and conditions and across 3 sentence segments (pre-, during-, and post-Stroop).ResultsIncreased cognitive load in the incongruent condition was associated with increased articulatory coordination variability and movement duration, compared to the congruent Stroop condition, for both age groups. Overall, the effect of increased cognitive load was greater for older adults than younger adults and was greatest in the portion of the sentence in which cognitive load was manipulated (during-Stroop), followed by the pre-Stroop segment. Sentence production accuracy was reduced for older adults in the incongruent condition.ConclusionsIncreased cognitive load involving response inhibition, selective attention, and working memory processes within a speech production task disrupted both the stability and timing with which speech was produced by both age groups. Older adults' speech motor performance may have been more affected due to age-related changes in cognitive and motoric functions that result in altered motor cognition.

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Development of the corticospinal system and hand motor function: central conduction times and motor performance tests

Developmental Medicine & Child Neurology ◽

10.1017/s0012162200000384 ◽

2000 ◽

Vol 42 (4) ◽

pp. 220-227 ◽

Cited By ~ 58

Author(s):

U M Fietzek ◽

F Heinen ◽

S Berweck ◽

S Maute ◽

A Hufschmidt ◽

...

Keyword(s):

Motor Function ◽

Motor Performance ◽

Performance Tests ◽

Corticospinal System

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A new motor performance test in a prospective study on children with suspected myopathy

Developmental Medicine & Child Neurology ◽

10.1017/s0012162206001587 ◽

2006 ◽

Vol 48 (09) ◽

pp. 739 ◽

Cited By ~ 3

Author(s):

Willeke A van den Beld ◽

Gitty AC van der Sanden ◽

Ton Feuth ◽

Anjo JWM Janssen ◽

Rob CA Sengers ◽

...

Keyword(s):

Prospective Study ◽

Motor Performance ◽

Performance Test ◽

A Prospective Study

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Cognitive Aging in a Precision Sport Context

European Psychologist ◽

10.1027/1016-9040.1.3.166 ◽

1996 ◽

Vol 1 (3) ◽

pp. 166-179 ◽

Cited By ~ 6

Author(s):

Bo Molander ◽

Lars Bäckman

Keyword(s):

Older Adult ◽

Cognitive Abilities ◽

Cognitive Aging ◽

Motor Performance ◽

Intervention Programs ◽

Laboratory Studies ◽

High Arousal ◽

Memory And Attention ◽

Age Related ◽

Principal Finding

Highly skilled miniature golf players were examined in a series of field and laboratory studies. The principal finding from these studies is that young and young adult players (range = 15-38 years) score equally well or better in competition than in training whereas older adult players (range = 46-73 years) perform worse in competitive events than under training conditions. It was also found that the impairment in motor performance on the part of the older players is associated with age-related deficits in basic cognitive abilities, such as memory and attention. These results support the hypothesis that older players may be able to compensate for age-related deficits under relaxed conditions, but not under conditions of high arousal. The possibility of improving the performance of the older players in stressful situations by means of various intervention programs is discussed.

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