scholarly journals Patterns of Spontaneous Purkinje Cell Complex Spike Activity in the Awake Rat

1999 ◽  
Vol 19 (7) ◽  
pp. 2728-2739 ◽  
Author(s):  
Eric J. Lang ◽  
Izumi Sugihara ◽  
John P. Welsh ◽  
Rodolfo Llinás
Keyword(s):  
Purkinje Cell ◽  
Spike Activity ◽  
Cell Complex ◽  
Complex Spike ◽  
Awake Rat

Developmental Changes in Evoked Purkinje Cell Complex Spike Responses

2003 ◽  
Vol 90 (4) ◽  
pp. 2349-2357 ◽  
Author(s):  
Daniel A. Nicholson ◽  
John H. Freeman
Keyword(s):  
Motor Learning ◽  
Purkinje Cell ◽  
Inferior Olive ◽  
Cell Complex ◽  
Climbing Fibers ◽  
Somatosensory Stimulation ◽  
Complex Spike ◽  
Long Latency ◽  
Inhibitory Feedback ◽  
Complex Spikes

The development of synaptic interconnections between the cerebellum and inferior olive, the sole source of climbing fibers, could contribute to the ontogeny of certain forms of motor learning (e.g., eyeblink conditioning). Purkinje cell complex spikes are produced exclusively by climbing fibers and exhibit short- and long-latency activity in response to somatosensory stimulation. Previous studies have demonstrated that evoked short- and long-latency complex spikes generally occur on separate trials and that this response segregation is regulated by inhibitory feedback to the inferior olive. The present experiment tested the hypothesis that complex spikes evoked by periorbital stimulation are regulated by inhibitory feedback from the cerebellum and that this feedback develops between postnatal days (PND) 17 and 24. Recordings from individual Purkinje cell complex spikes in urethan-anesthetized rats indicated that the segregation of short- and long-latency evoked complex spike activity emerges between PND17 and PND24. In addition, infusion of picrotoxin, a GABAA-receptor antagonist, into the inferior olive abolished the response pattern segregation in PND24 rats, producing evoked complex spike response patterns similar to those characteristic of younger rats. These data support the view that cerebellar feedback to the inferior olive, which is exclusively inhibitory, undergoes substantial changes in the same developmental time window in which certain forms of motor learning emerge.

scholarly journals Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar system

2014 ◽  
Vol 8 ◽  
Author(s):  
Eric J. Lang ◽  
Tianyu Tang ◽  
Colleen Y. Suh ◽  
Jianqiang Xiao ◽  
Yuriy Kotsurovskyy ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Cell Complex ◽  
Complex Spike

scholarly journals A Purkinje cell model that simulates complex spikes

2020 ◽  
Author(s):  
Amelia Burroughs ◽  
Nadia L. Cerminara ◽  
Richard Apps ◽  
Conor Houghton
Keyword(s):  
Action Potential ◽  
Purkinje Cell ◽  
Spike Activity ◽  
Cell Model ◽  
Compartment Model ◽  
Complex Spike ◽  
Simple Spike ◽  
Lower Amplitude ◽  
Complex Spikes

AbstractPurkinje cells are the principal neurons of the cerebellar cortex. One of their distinguishing features is that they fire two distinct types of action potential, called simple and complex spikes, which interact with one another. Simple spikes are stereotypical action potentials that are elicited at high, but variable, rates (0 – 100 Hz) and have a consistent waveform. Complex spikes are composed of an initial action potential followed by a burst of lower amplitude spikelets. Complex spikes occur at comparatively low rates (~ 1 Hz) and have a variable waveform. Although they are critical to cerebellar operation a simple model that describes the complex spike waveform is lacking. Here, a novel single-compartment model of Purkinje cell electrodynamics is presented. The simpler version of this model, with two active conductances and a leak channel, can simulate the features typical of complex spikes recorded in vitro. If calcium dynamics are also included, the model can capture the pause in simple spike activity that occurs after complex spike events. Together, these models provide an insight into the mechanisms behind complex spike spikelet generation, waveform variability and their interactions with simple spike activity.

Complex Spike Activity in the Flocculus Signals More than the Eye Can See

2002 ◽  
Vol 978 (1 THE CEREBELLU) ◽  
pp. 232-236 ◽  
Author(s):  
J. I. SIMPSON ◽  
T. BELTON ◽  
M. SUH ◽  
B. WINKELMAN
Keyword(s):  
Spike Activity ◽  
Complex Spike
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