scholarly journals Chronic Morphine Treatment Switches the Effect of Dopamine on Excitatory Synaptic Transmission from Inhibition to Excitation in Pyramidal Cells of the Basolateral Amygdala

2011 ◽  
Vol 31 (48) ◽  
pp. 17527-17536 ◽  
Author(s):  
Z. Li ◽  
W. Luan ◽  
Y. Chen ◽  
M. Chen ◽  
Y. Dong ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Basolateral Amygdala ◽  
Pyramidal Cells ◽  
Excitatory Synaptic Transmission ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Chronic Morphine Treatment

scholarly journals Chronic Morphine Treatment Alters NMDA Receptor-Mediated Synaptic Transmission in the Nucleus Accumbens

1999 ◽  
Vol 19 (20) ◽  
pp. 9081-9089 ◽  
Author(s):  
Gilles Martin ◽  
Serge H. Ahmed ◽  
Thomas Blank ◽  
Joachim Spiess ◽  
George F. Koob ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nmda Receptor ◽  
Synaptic Transmission ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Chronic Morphine Treatment

Dopamine receptor subsensitivity in the substantia nigra after chronic morphine treatment in rats

1988 ◽  
Vol 150 (1-2) ◽  
pp. 113-122 ◽  
Author(s):  
U. Spampinato ◽  
H. Gozlan ◽  
G. Daval ◽  
C.M. Fattaccini ◽  
M. Hamon
Keyword(s):  
Substantia Nigra ◽  
Dopamine Receptor ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Chronic Morphine Treatment

Development of Excitatory Circuitry in the Hippocampus

1998 ◽  
Vol 79 (4) ◽  
pp. 2013-2024 ◽  
Author(s):  
Albert Y. Hsia ◽  
Robert C. Malenka ◽  
Roger A. Nicoll
Keyword(s):  
Synaptic Transmission ◽  
Action Potentials ◽  
Pyramidal Cells ◽  
Excitatory Synaptic Transmission ◽  
Developmental Strategy ◽  
Excitatory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Quantal Size ◽  
Physiological Approach ◽  
Local Circuitry

Hsia, Albert Y., Robert C. Malenka, and Roger A. Nicoll. Development of excitatory circuitry in the hippocampus. J. Neurophysiol. 79: 2013–2024, 1998. Assessing the development of local circuitry in the hippocampus has relied primarily on anatomic studies. Here we take a physiological approach, to directly evaluate the means by which the mature state of connectivity between CA3 and CA1 hippocampal pyramidal cells is established. Using a technique of comparing miniature excitatory postsynaptic currents (mEPSCs) to EPSCs in response to spontaneously occurring action potentials in CA3 cells, we found that from neonatal to adult ages, functional synapses are created and serve to increase the degree of connectivity between CA3-CA1 cell pairs. Neither the probability of release nor mean quantal size was found to change significantly with age. However, the variability of quantal events decreases substantially as synapses mature. Thus in the hippocampus the developmental strategy for enhancing excitatory synaptic transmission does not appear to involve an increase in the efficacy at individual synapses, but rather an increase in the connectivity between cell pairs.

Effect of chronic morphine treatment on time-course of free radical processes

2007 ◽  
Vol 1 (3) ◽  
pp. 245-248
Author(s):  
D. A. Miskevich ◽  
N. E. Petushok ◽  
V. V. Lelevich ◽  
S. V. Lelevich ◽  
A. N. Borodinsky
Keyword(s):  
Free Radical ◽  
Time Course ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Free Radical Processes ◽  
Chronic Morphine Treatment ◽  
Radical Processes

scholarly journals Influences of Morphine on the Spontaneous and Evoked Excitatory Postsynaptic Currents in Lateral Amygdala of Rats

2016 ◽  
pp. 165-169 ◽  
Author(s):  
J.-J. ZHANG ◽  
X.-D. LIU ◽  
L.-C. YU
Keyword(s):  
Synaptic Transmission ◽  
Excitatory Synaptic Transmission ◽  
Morphine Treatment ◽  
Lateral Amygdala ◽  
Excitatory Postsynaptic Currents ◽  
Postsynaptic Currents ◽  
Whole Cell Patch Clamp ◽  
The Central Nervous System ◽  
Underlying Mechanisms

Acute morphine exposure induces antinociceptive activity, but the underlying mechanisms in the central nervous system are unclear. Using whole-cell patch clamp recordings, we explore the role of morphine in the modulation of excitatory synaptic transmission in lateral amygdala neurons of rats. The results demonstrate that perfusion of 10 μM of morphine to the lateral amygdala inhibits the discharge frequency significantly. We further find that there are no significant influences of morphine on the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs). Interestingly, morphine shows no marked influence on the evoked excitatory postsynaptic currents (eEPSCs) in the lateral amygdala neurons. These results indicate that acute morphine treatment plays an important role in the modulation on the excitatory synaptic transmission in lateral amygdala neurons of rats.

Deglycosylation of Fas receptor and chronic morphine treatment up-regulate high molecular mass Fas aggregates in the rat brain

2004 ◽  
Vol 496 (1-3) ◽  
pp. 63-69 ◽  
Author(s):  
Marı́a Julia Garcı́a-Fuster ◽  
Marcel Ferrer-Alcón ◽  
Antonio Miralles ◽  
Jesús Andrés Garcı́a-Sevilla
Keyword(s):  
Molecular Mass ◽  
Rat Brain ◽  
High Molecular Mass ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Fas Receptor ◽  
Chronic Morphine Treatment
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