scholarly journals Target Cell-Specific Involvement of Presynaptic Mitochondria in Post-Tetanic Potentiation at Hippocampal Mossy Fiber Synapses

2007 ◽  
Vol 27 (50) ◽  
pp. 13603-13613 ◽  
Author(s):  
D. Lee ◽  
K.-H. Lee ◽  
W.-K. Ho ◽  
S.-H. Lee
Keyword(s):  
Target Cell ◽  
Mossy Fiber ◽  
Post Tetanic Potentiation

scholarly journals Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
David Vandael ◽  
Yuji Okamoto ◽  
Peter Jonas
Keyword(s):  
Pyramidal Neurons ◽  
Mossy Fiber ◽  
Brain Slices ◽  
High Frequency Stimulation ◽  
Short Term Plasticity ◽  
Glutamate Signaling ◽  
Frequency Stimulation ◽  
Post Tetanic Potentiation ◽  
Mossy Fiber Synapse ◽  
Ca3 Neurons

AbstractThe hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP is an entirely presynaptic phenomenon, implying that PTP induction is input-specific, and requires neither activity of multiple inputs nor stimulation of postsynaptic neurons. To directly test cooperativity and associativity, we made paired recordings between single mossy fiber terminals and postsynaptic CA3 pyramidal neurons in rat brain slices. By stimulating non-overlapping mossy fiber inputs converging onto single CA3 neurons, we confirm that PTP is input-specific and non-cooperative. Unexpectedly, mossy fiber PTP exhibits anti-associative induction properties. EPSCs show only minimal PTP after combined pre- and postsynaptic high-frequency stimulation with intact postsynaptic Ca2+ signaling, but marked PTP in the absence of postsynaptic spiking and after suppression of postsynaptic Ca2+ signaling (10 mM EGTA). PTP is largely recovered by inhibitors of voltage-gated R- and L-type Ca2+ channels, group II mGluRs, and vacuolar-type H+-ATPase, suggesting the involvement of retrograde vesicular glutamate signaling. Transsynaptic regulation of PTP extends the repertoire of synaptic computations, implementing a brake on mossy fiber detonation and a “smart teacher” function of hippocampal mossy fiber synapses.

scholarly journals Compartmentalized Ca2+ Channel Regulation at Divergent Mossy-Fiber Release Sites Underlies Target Cell-Dependent Plasticity

Neuron ◽  
2006 ◽  
Vol 52 (3) ◽  
pp. 497-510 ◽  
Author(s):  
Kenneth A. Pelkey ◽  
Lisa Topolnik ◽  
Jean-Claude Lacaille ◽  
Chris J. McBain
Keyword(s):  
Target Cell ◽  
Mossy Fiber ◽  
Dependent Plasticity ◽  
Channel Regulation

scholarly journals Retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 pyramidal cell synapse

eNeuro ◽  
2021 ◽  
pp. ENEURO.0450-20.2021
Author(s):  
Sachin Makani ◽  
Stefano Lutzu ◽  
Pablo J. Lituma ◽  
David L. Hunt ◽  
Pablo E. Castillo
Keyword(s):  
Pyramidal Cell ◽  
Mossy Fiber ◽  
Post Tetanic Potentiation ◽  
Cell Synapse

scholarly journals Retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 pyramidal cell synapse

2020 ◽  
Author(s):  
Sachin Makani ◽  
Stefano Lutzu ◽  
Pablo J. Lituma ◽  
David L. Hunt ◽  
Pablo E. Castillo
Keyword(s):  
Metabotropic Glutamate Receptors ◽  
Granule Cells ◽  
Mossy Fiber ◽  
Hippocampal Slices ◽  
Dependent Manner ◽  
Short Term ◽  
Short Term Plasticity ◽  
Dentate Granule Cells ◽  
Post Tetanic Potentiation ◽  
Frequency Facilitation

ABSTRACTIn the hippocampus, the excitatory synapse between dentate granule cell axons – or mossy fibers (MF) – and CA3 pyramidal cells (MF-CA3) expresses robust forms of short-term plasticity, such as frequency facilitation and post-tetanic potentiation (PTP). These forms of plasticity are due to increases in neurotransmitter release, and can be engaged when dentate granule cells fire in bursts (e.g. during exploratory behaviors) and bring CA3 pyramidal neurons above threshold. While frequency facilitation at this synapse is limited by endogenous activation of presynaptic metabotropic glutamate receptors, whether MF-PTP can be regulated in an activity-dependent manner is unknown. Here, using physiologically relevant patterns of mossy fiber stimulation in acute mouse hippocampal slices, we found that disrupting postsynaptic Ca2+ dynamics increases MF-PTP, strongly suggesting a form of Ca2+-dependent retrograde suppression of this form of plasticity. PTP suppression requires a few seconds of MF bursting activity and Ca2+ release from internal stores. Our findings raise the possibility that the powerful MF-CA3 synapse can negatively regulate its own strength not only during PTP-inducing activity typical of normal exploratory behaviors, but also during epileptic activity.SIGNIFICANCE STATEMENTThe powerful mossy fiber-CA3 synapse exhibits strong forms of plasticity that are engaged during location-specific exploration, when dentate granule cells fire in bursts. While this synapse is well-known for its presynaptically-expressed LTP and LTD, much less is known about the robust changes that occur on a shorter time scale. How such short-term plasticity is regulated, in particular, remains poorly understood. Unexpectedly, an in vivo-like pattern of presynaptic activity induced robust post-tetanic potentiation (PTP) only when the postsynaptic cell was loaded with a high concentration of Ca2+ buffer, indicating a form of Ca2+–dependent retrograde suppression of PTP. Such suppression may have profound implications for how environmental cues are encoded into neural assemblies, and for limiting network hyperexcitability during seizures.

scholarly journals Target-Cell Specificity of Kainate Autoreceptor and Ca2+-Store-Dependent Short-Term Plasticity at Hippocampal Mossy Fiber Synapses

2008 ◽  
Vol 28 (49) ◽  
pp. 13139-13149 ◽  
Author(s):  
R. Scott ◽  
T. Lalic ◽  
D. M. Kullmann ◽  
M. Capogna ◽  
D. A. Rusakov
Keyword(s):  
Target Cell ◽  
Mossy Fiber ◽  
Short Term ◽  
Short Term Plasticity ◽  
Cell Specificity

scholarly journals Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Nicholas P Vyleta ◽  
Carolina Borges-Merjane ◽  
Peter Jonas
Keyword(s):  
Granule Cells ◽  
Mossy Fiber ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Short Term ◽  
Short Term Plasticity ◽  
Cell Network ◽  
Post Tetanic Potentiation ◽  
Ca3 Pyramidal Cells ◽  
Ca3 Neurons

Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network.

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