scholarly journals Alcohol Potently Modulates Climbing Fiber->Purkinje Neuron Synapses: Role of Metabotropic Glutamate Receptors

2006 ◽  
Vol 26 (7) ◽  
pp. 1906-1912 ◽  
Author(s):  
M. Carta
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Purkinje Neuron ◽  
Climbing Fiber ◽  
Metabotropic Glutamate

scholarly journals The G Protein-Coupled Glutamate Receptors as Novel Molecular Targets in Schizophrenia Treatment—A Narrative Review

2021 ◽  
Vol 10 (7) ◽  
pp. 1475
Author(s):  
Waldemar Kryszkowski ◽  
Tomasz Boczek
Keyword(s):  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Glutamate Release ◽  
Molecular Targets ◽  
Brain Regions ◽  
Psychotic Symptoms ◽  
Unknown Etiology ◽  
Metabotropic Glutamate ◽  
G Protein Coupled

Schizophrenia is a severe neuropsychiatric disease with an unknown etiology. The research into the neurobiology of this disease led to several models aimed at explaining the link between perturbations in brain function and the manifestation of psychotic symptoms. The glutamatergic hypothesis postulates that disrupted glutamate neurotransmission may mediate cognitive and psychosocial impairments by affecting the connections between the cortex and the thalamus. In this regard, the greatest attention has been given to ionotropic NMDA receptor hypofunction. However, converging data indicates metabotropic glutamate receptors as crucial for cognitive and psychomotor function. The distribution of these receptors in the brain regions related to schizophrenia and their regulatory role in glutamate release make them promising molecular targets for novel antipsychotics. This article reviews the progress in the research on the role of metabotropic glutamate receptors in schizophrenia etiopathology.

scholarly journals Ethanol tachyphylaxis in spinal cord motorneurons: role of metabotropic glutamate receptors

2003 ◽  
Vol 138 (8) ◽  
pp. 1417-1424 ◽  
Author(s):  
Hui-Fang Li ◽  
Meng-Ya Wang ◽  
Jessica Knape ◽  
Joan J Kendig
Keyword(s):  
Spinal Cord ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate

Role of peripheral group I and II metabotropic glutamate receptors in IL-1β-induced mechanical allodynia in the orofacial area of conscious rats

Pain ◽  
2005 ◽  
Vol 118 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Dong K. Ahn ◽  
Kwang H. Kim ◽  
Chang Y. Jung ◽  
Hyo S. Choi ◽  
Eun J. Lim ◽  
...  
Keyword(s):  
Glutamate Receptors ◽  
Mechanical Allodynia ◽  
Metabotropic Glutamate Receptors ◽  
Conscious Rats ◽  
Metabotropic Glutamate ◽  
Group I
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