scholarly journals Biphasic Coupling of Neuronal Nitric Oxide Synthase Phosphorylation to the NMDA Receptor Regulates AMPA Receptor Trafficking and Neuronal Cell Death

2007 ◽  
Vol 27 (13) ◽  
pp. 3445-3455 ◽  
Author(s):  
G. A. Rameau ◽  
D. S. Tukey ◽  
E. D. Garcin-Hosfield ◽  
R. F. Titcombe ◽  
C. Misra ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Nmda Receptor ◽  
Nitric Oxide Synthase ◽  
Ampa Receptor ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Neuronal Nitric Oxide Synthase ◽  
Receptor Trafficking ◽  
Oxide Synthase

Heme oxygenase-2 distribution in anorectum: colocalization with neuronal nitric oxide synthase

2000 ◽  
Vol 278 (1) ◽  
pp. G148-G155 ◽  
Author(s):  
Raman Battish ◽  
Gao-Yuan Cao ◽  
Richard B. Lynn ◽  
Sushanta Chakder ◽  
Satish Rattan
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Heme Oxygenase ◽  
Anal Verge ◽  
Neuronal Cell ◽  
Neuronal Nitric Oxide Synthase ◽  
High Rate ◽  
Neuronal Cell Bodies ◽  
Oxide Synthase ◽  
Messenger Molecule

Recent investigations have suggested carbon monoxide (CO) as a putative messenger molecule. Although several studies have implicated the heme oxygenase (HO) pathway, responsible for the endogenous production of CO, in the neuromodulatory control of the internal anal sphincter (IAS), its exact role is not known. Nitric oxide, produced by neuronal nitric oxide synthase (nNOS) of myenteric neurons, is an important inhibitory neural messenger molecule mediating nonadrenergic noncholinergic (NANC) relaxation of the IAS. The present studies were undertaken to investigate in detail the presence and coexistence of heme oxygenase-2 (HO-2) with nNOS in the opossum anorectum. In perfusion-fixed, frozen-sectioned tissue, HO-2 immunoreactive (IR) and nNOS IR nerves were identified using immunocytochemistry. Ganglia containing HO-2 IR neuronal cell bodies were present in the myenteric and submucosal plexuses throughout the entire anorectum. Colocalization of HO-2 IR and nNOS IR was nearly 100% in the IAS and decreased proximally from the anal verge. In the rectum, colocalization of HO-2 IR and nNOS IR was ∼70%. Additional confocal microscopy studies using c-Kit staining demonstrated the localization of HO-2 IR and nNOS IR in interstitial cells of Cajal (ICC) of the anorectum. From the high rate of colocalization of HO-2 IR and nNOS IR in the IAS as well as the localization of HO-2 IR and nNOS IR in ICC in conjunction with earlier studies of the HO pathway, we speculate an interaction between HO and NOS pathways in the NANC inhibitory neurotransmission of the IAS and rectum.

Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

2016 ◽  
Vol 610 ◽  
pp. 48-53 ◽  
Author(s):  
Toshifumi Yamamoto ◽  
Tomomi Nakayama ◽  
Junji Yamaguchi ◽  
Maaya Matsuzawa ◽  
Masayoshi Mishina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptor ◽  
Nitric Oxide Synthase ◽  
Behavioral Sensitization ◽  
Neuronal Nitric Oxide Synthase ◽  
Oxide Synthase

scholarly journals Neuronal Nitric Oxide Synthase Is Crucial for Ganglion Cell Death in Rat Retinal Explant Cultures

2004 ◽  
Vol 94 (1) ◽  
pp. 77-80 ◽  
Author(s):  
Hiroshi Katsuki ◽  
Rie Yamamoto ◽  
Daisuke Nakata ◽  
Toshiaki Kume ◽  
Akinori Akaike
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Nitric Oxide Synthase ◽  
Ganglion Cell ◽  
Neuronal Nitric Oxide Synthase ◽  
Explant Cultures ◽  
Ganglion Cell Death ◽  
Oxide Synthase
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