scholarly journals Molecular and Biophysical Properties of Voltage-Gated Na+ Channels in Murine Vas Deferens

2008 ◽  
Vol 94 (8) ◽  
pp. 3340-3351 ◽  
Author(s):  
Hai-Lei Zhu ◽  
Manami Aishima ◽  
Hidetaka Morinaga ◽  
Richard D. Wassall ◽  
Atsushi Shibata ◽  
...  
Keyword(s):  
Vas Deferens ◽  
Na Channels ◽  
Biophysical Properties ◽  
Voltage Gated

Effects of 4,9-anhydrotetrodotoxin on voltage-gated Na+ channels of mouse vas deferens myocytes and recombinant NaV1.6 channels

2018 ◽  
Vol 391 (5) ◽  
pp. 489-499 ◽  
Author(s):  
Kohei Takahara ◽  
Tadashi Yamamoto ◽  
Keiichiro Uchida ◽  
Hai-Lei Zhu ◽  
Atsushi Shibata ◽  
...  
Keyword(s):  
Vas Deferens ◽  
Na Channels ◽  
Mouse Vas Deferens ◽  
Voltage Gated

scholarly journals Kv5, Kv6, Kv8, and Kv9 subunits: No simple silent bystanders

2016 ◽  
Vol 147 (2) ◽  
pp. 105-125 ◽  
Author(s):  
Elke Bocksteins
Keyword(s):  
Therapeutic Strategies ◽  
K Channel ◽  
Biophysical Properties ◽  
Tissue Specific ◽  
Voltage Gated ◽  
Novel Treatments ◽  
Novel Therapeutic Strategies ◽  
Different Tissues ◽  
Novel Therapeutic

Members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, collectively identified as electrically silent voltage-gated K+ channel [KvS] subunits) do not form functional homotetrameric channels but assemble with Kv2 subunits into heterotetrameric Kv2/KvS channels with unique biophysical properties. Unlike the ubiquitously expressed Kv2 subunits, KvS subunits show a more restricted expression. This raises the possibility that Kv2/KvS heterotetramers have tissue-specific functions, making them potential targets for the development of novel therapeutic strategies. Here, I provide an overview of the expression of KvS subunits in different tissues and discuss their proposed role in various physiological and pathophysiological processes. This overview demonstrates the importance of KvS subunits and Kv2/KvS heterotetramers in vivo and the importance of considering KvS subunits and Kv2/KvS heterotetramers in the development of novel treatments.

scholarly journals Actions of kurtoxin on tetrodotoxin-sensitive voltage-gated Na+ currents, NaV1.6, in murine vas deferens myocytes

2009 ◽  
Vol 379 (5) ◽  
pp. 453-460 ◽  
Author(s):  
Hai-Lei Zhu ◽  
Richard D. Wassall ◽  
Thomas C. Cunnane ◽  
Noriyoshi Teramoto
Keyword(s):  
Vas Deferens ◽  
Voltage Gated ◽  
Na Currents
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