A CASE OF CUSHING'S SYNDROME STUDIED BY URINARY CORTICOTROPHIN ASSAY
Keyword(s):
ABSTRACT A 20 year old female developed typical features of Cushing's syndrome, with increased urinary and plasma 17-OHCS, which showed a distinct diurnal variation, exaggerated response to exogenous ACTH, and suppression of response to 3 mg dexamethasone daily. Total adrenalectomy was performed for bilateral adrenal hyperplasia. ACTH in urine showed a distinct increase before and after operation. More than 30 mg of cortisol was required to suppress the elevated urinary ACTH, suggesting an abnormal response of the pituitary gland to exogenous steroid.
1962 ◽
Vol 41
(10)
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pp. 1871-1885
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1979 ◽
Vol 16
(1-6)
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pp. 86-88
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