TREATMENT OF GROWTH DISTURBANCES WITH ANABOLIC STEROIDS

SummarySix anabolic steroids were assessed for their ability to enhance plasma fibrinolytic activity in males with ischaemic heart disease. Five 17α-alkylated steroids (Ethyloestrenol, Norethandrolone, Methandienone, Methylandrostenediol and Oxymetholone) were examined and all produced a significant increase in plasma plasminogen activator as measured by the euglobulin lysis time. The only non-17α-alkylated steroid studied (Methenolone acetate) failed to enhance fibrinolysis. The 17α-alkylated steroids studied all deserve more detailed evaluation of their long term effects on plasma fibrinolytic activity.

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Effect of Anabolic Steroids on Plasma Antithrombin III

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651450 ◽

1975 ◽

Vol 34 (01) ◽

pp. 106-114 ◽

Cited By ~ 3

Author(s):

I. D Walker ◽

J. F Davidson ◽

P Young ◽

J. A Conkie

Keyword(s):

Heart Disease ◽

Ischaemic Heart Disease ◽

Oral Contraceptives ◽

Disseminated Intravascular Coagulation ◽

Fibrinolytic Activity ◽

Antithrombin Iii ◽

Anabolic Steroids ◽

Intravascular Coagulation ◽

Clear Cut ◽

Α2 Macroglobulin

SummaryThe effect of seven different anabolic steroids (Ethyloestrenol, Methenolone acetate, Norethandrolone, Methylandrostenediol, Oxymetholone, Methandienone, and Stanozolol) on three α-globulin antiprotease inhibitors of thrombin and plasmin was studied in men with ischaemic heart disease. In distinct contrast to the oral contraceptives, five of the six 17-α-alkylated anabolic steroids studied produced increased plasma Antithrombin III levels and five produced decreased levels of plasma α2-macroglobulin. The effect on plasma α1antitrypsin levels was less clear-cut but three of the steroids examined produced significantly elevated levels. The increased plasma fibrinolytic activity which the 17-α-alkylated anabolic steroids induce is therefore unlikely to be secondary to disseminated intravascular coagulation.

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CORTICOSTEROID-UMSATZ UND CORTICOSTEROID-PRODUKTION BEI RATTEN UNTER DER BEHANDLUNG MIT ANABOLEN STEROIDEN

Acta Endocrinologica ◽

10.1530/acta.0.0480263 ◽

1965 ◽

Vol 48 (2) ◽

pp. 263-271 ◽

Cited By ~ 8

Author(s):

Herbert Schriefers ◽

Gerlinde Scharlau ◽

Franzis Pohl

Keyword(s):

Production Rate ◽

Adult Female ◽

Anabolic Steroids ◽

Reduction Rate ◽

Female Rats ◽

Adrenal Weight ◽

Hydrogenase Activity ◽

Anabolic Effect ◽

Liver Slices

ABSTRACT After the administration of anabolic steroids to adult female rats in daily doses of 1 mg per animal for 14 days, the following parameters were investigated: the rate of the Δ4-5α-hydrogenase-catalyzed cortisone reduction in liver slices and microsomal fractions, the adrenal weight and the in vitro corticosterone production rate. Among the steroids tested, only 17α-methyl-testosterone and 17α-ethyl-19-nor-testosterone were effective in lowering significantly cortisone reduction rate by liver slices with concomitant decreases in microsomal Δ4-5α-hydrogenase-activity. Testosterone, 19-nor-testosterone, 17α-ethinyl-19-nor-testosterone, 17α-methyl-17β-hydroxy-androsta-1,4-dien-3-one and 1-methyl-17β-hydroxy-androst-1-en-3-one were ineffective or only slightly effective. Adrenal weight and absolute corticosterone production rate (μg/60 min per animal) were decreased after treatment with 17α-methyl-testosterone, 17α-ethyl-19-nor-testosterone and 1-methyl-17β-hydroxy-androst-1-en-3-one. Corticosterone production was decreased with 17α-ethinyl-19-nor-testosterone in spite of an unchanged adrenal weight. The relative corticosterone production rate (μg/60 min · 100 mg adrenal) was in any cases unaffected. According to these results there exists – with the exception of 17α-ethinyl-19-nor-testosterone – a strict parallelism between corticosteroid turnover and corticosterone production rate: unchanged turnover is correlated with unchanged corticosterone production rate, while a decreased turnover is correlated with decreased adrenal activity. The protein-anabolic effect of certain anabolic steroids may be partly due to an anti-catabolic action of these compounds resulting from a decreased corticosteroid inactivation and production rate. Possible mechanisms by which anabolic steroids may affect corticosteroid-balance are discussed.

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TREATMENT OF PROGRESSIVE MUSCULAR DYSTROPHY IN PARTICULAR WITH THE ANABOLIC STEROIDS

Acta Endocrinologica ◽

10.1530/acta.0.039s175 ◽

1962 ◽

Vol 39 (3_Suppl) ◽

pp. S175-S184 ◽

Cited By ~ 2

Author(s):

E. de Toni

Keyword(s):

Muscular Dystrophy ◽

Anabolic Steroids ◽

Progressive Muscular Dystrophy

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THE EFFECT OF CORTISONE AND ANABOLIC STEROIDS ON THE RETENTION OF RADIOACTIVE CALCIUM AND STRONTIUM IN RATS

Acta Endocrinologica ◽

10.1530/acta.0.0470223 ◽

1964 ◽

Vol 47 (2) ◽

pp. 223-230 ◽

Cited By ~ 6

Author(s):

Hans H. Bohr ◽

Steen G. Dawids

Keyword(s):

Marked Reduction ◽

Anabolic Steroids ◽

Adult Rats ◽

Increased Retention

ABSTRACT Experiments with adult rats treated with dexamethasone showed a decreased retention of radioactive calcium and strontium as compared with the control animals. In addition a marked reduction in weight was observed probably due to dehydration. In animals which had additional injections of nortestosterone compounds, i. e. Durabolin® and Anadur® respectively, these effects of cortisone were not counteracted although animals treated with nortestosterone compounds alone showed an increased retention of radioactive calcium as compared with the control animals.

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Anabolic steroids and their effects of on neuronal density in cortical areas and hippocampus of mice

Brazilian Journal of Biology ◽

10.1590/1519-6984.224642 ◽

2020 ◽

Author(s):

B. Damião ◽

W. C. Rossi-Junior ◽

F. D. R. Guerra ◽

P. P. Marques ◽

D. A. Nogueira ◽

...

Keyword(s):

Nervous Tissue ◽

Anabolic Steroids ◽

Hippocampal Region ◽

Behavioral Impairment ◽

Neuronal Density ◽

Cortical Areas ◽

Illicit Use ◽

And Performance ◽

Serial Samples ◽

Considerable Damage

Abstract Anabolic substances have been increasingly used by bodybuilders and athletes with the goal of improving performance and aesthetics. However, this practice has caused some concern to physicians and researchers because of unknowledge of consequences that the indiscriminate and illicit use of these substances can cause. Thus, this study analyzed the effects of two commercially available anabolic steroids (AS), Winstrol Depot® (Stanozolol) and Deposteron® (Testosterone Cypionate), in the neuronal density of limbic, motor and sensory regions on the cerebral cortex and in CA1, CA2, CA3 regions of the hippocampus. A total of 60 Swiss mice were used (30 males and 30 females), separated into three groups: control and two experimental groups, which received the AAS. From each brain, homotypic and semi-serial samples were taken in frontal sections from areas established for the study. The results showed that females treated with testosterone cypionate presented a reduction in all regions tested and the ones treated with Stanozolol showed a decrease in some hippocampal areas. Regarding male animals, stanozolol led to a decrease in neuron number in one hippocampal region. These data allow us to conclude that supra-physiological doses of steroids used in this study, can cause considerable damage to nervous tissue with ultrastructural and consequently behavioral impairment. These changes could interfere with the loss of physical yield and performance of athletes and non-athletes and may cause irreparable damage to individuals making irresponsible use of anabolic steroids.

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