INVESTIGATIONS ON LIPID AND CHOLESTEROL CONTENT OF THE ADRENAL CORTEX OF RATS AFTER ADMINISTRATION OF PYRIDINE-4-CARBONIC ACID-(DEXAMETHASONE-21′-)ESTERS

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S72
Author(s):  
Heinz Ueberberg
Keyword(s):  
Adrenal Cortex ◽  
Carbonic Acid ◽  
Cholesterol Content

INFLUENCE OF A HIGHLY PURIFIED THYMUS EXTRACT UPON THE ADRENALS OF GUINEA-PIGS

1955 ◽  
Vol 13 (1) ◽  
pp. 7-10 ◽  
Author(s):  
J. COMSA ◽  
H. LEROUX
Keyword(s):  
Vitamin C ◽  
Adrenal Cortex ◽  
Guinea Pigs ◽  
Relative Weight ◽  
Cholesterol Content ◽  
Transient Increase ◽  
Daily Injection ◽  
Thymus Extract

SUMMARY 1. An attempt has been made to demonstrate the influence of the thymus upon the adrenal in guinea-pigs by daily injection of unphysiological amounts of a highly purified thymus extract. 2. Such injections caused a marked but transient increase in both the vitamin C and cholesterol content of the adrenal. 3. Morphologically, there was a decrease in the weight of the adrenal cortex relative to that of the whole gland, while the relative weight of the medulla increased correspondingly. This change was not transient, but persisted up to 110 days of treatment. 4. It is concluded that the effect of injecting thymus extract is opposite to that of injecting ACTH and gives rise to a resting condition of the adrenal cortex.

THE ADRENAL CORTEX IN RESTRAINT HYPOTHERMIA AND IN ADAPTATION TO THE STRESS OF RESTRAINT

1956 ◽  
Vol 14 (2) ◽  
pp. 181-187 ◽  
Author(s):  
R. G. BARTLETT ◽  
M. A. MILLER
Keyword(s):  
Ascorbic Acid ◽  
Adrenal Cortex ◽  
Cholesterol Content ◽  
Adaptive Procedure ◽  
Normal Body Temperature ◽  
Normal Body ◽  
Cholesterol Levels ◽  
Essentially Normal ◽  
Sufficient Magnitude

SUMMARY The role of the adrenal cortex in restraint-induced hypothermia and in adaptation to the stress of restraint was investigated. There was an increase in ascorbic acid and a less marked increase in the cholesterol content of the adrenals accompanying 1 week's exposure to the stress of light restraint to produce adaptation, as well as a decrease in the adrenal ascorbic acid and cholesterol levels accompanying restraintinduced hypothermia, but changes in adrenocortical activity were probably not of sufficient magnitude to account for either the increased thermostability after the adaptive procedure or the thermolability of the animals exposed to the short-term stress. It was also demonstrated that after a 7-day exposure to light restraint (to produce adaptation), adrenalectomized animals, maintained with isotonic salt solution or DCA, could not maintain a normal body temperature when restrained in the cold. Cortisone, whether administered alone or with DCA, permitted these adrenalectomized, adapted animals to maintain essentially normal body temperatures when exposed to restraint in the cold, indicating that adaptation had occurred.

Ultrastructural Cytopiasmic Changes of Adrenal Cortex During Pregnancy

1969 ◽  
Vol 27 ◽  
pp. 298-299
Author(s):  
T. M. Murad ◽  
Karen Israel ◽  
Jack C. Geer
Keyword(s):  
Adrenal Gland ◽  
Steroid Hormones ◽  
Adrenal Cortex ◽  
Lipid Droplets ◽  
Plasma Cholesterol ◽  
Adrenal Steroids ◽  
Dynamic Changes ◽  
Cortical Cells ◽  
Acetyl Coenzyme A ◽  
Adrenal Cortical Cells

Adrenal steroids are normally synthesized from acetyl coenzyme A via cholesterol. Cholesterol is also shown to enter the adrenal gland and to be localized in the lipid droplets of the adrenal cortical cells. Both pregnenolone and progesterone act as intermediates in the conversion of cholesterol into steroid hormones. During pregnancy an increased level of plasma cholesterol is known to be associated with an increase of the adrenal corticoid and progesterone. The present study is designed to demonstrate whether the adrenal cortical cells show any dynamic changes during pregnancy.

The Effect of Oxidized Cholesterol on the Aorta of Rabbits- Scanning Electron Microscopic Observations

1982 ◽  
Vol 40 ◽  
pp. 340-341
Author(s):  
S. K. Pena ◽  
C. B. Taylor ◽  
J. Hill ◽  
J. Safarik
Keyword(s):  
Cholesterol Biosynthesis ◽  
Cholesterol Content ◽  
Arterial Injury ◽  
Electron Microscopic ◽  
Aortic Smooth Muscle ◽  
Oxidized Cholesterol ◽  
Initial Event ◽  
Membrane Structure And Function ◽  
Scanning Electron Microscopic ◽  
And Function

Introduction: Oxidized cholesterol derivatives have been demonstrated in various cell cultures to be very potent inhibitors of 3-hvdroxy-3- methylglutaryl Coenzyme A reductase which is a principle regulator of cholesterol biosynthesis in the cell. The cholesterol content in the cells exposed to oxidized cholesterol was found to be markedly decreased. In aortic smooth muscle cells, the potency of this effect was closely related to the cytotoxicity of each derivative. Furthermore, due to the similarity of their molecular structure to that of cholesterol, these oxidized cholesterol derivatives might insert themselves into the cell membrane, alter membrane structure and function and eventually cause cell death. Arterial injury has been shown to be the initial event of atherosclerosis.

Adrenocortical Ultrastructure in Ectopic Acth Syndrome

1976 ◽  
Vol 34 ◽  
pp. 238-239
Author(s):  
K. Kovacs ◽  
E. Horvath ◽  
W. Singer
Keyword(s):  
Adrenal Cortex ◽  
Zona Glomerulosa ◽  
Ectopic Acth Syndrome ◽  
Pituitary Neoplasms ◽  
Electron Microscopic ◽  
Adrenocortical Cells ◽  
Cell Hyperplasia ◽  
Ectopic Acth ◽  
Ectopic Acth Production ◽  
Microscopic Findings

Secretion of ACTH by non-pituitary neoplasms is recognized with increasing frequency. While the clinical and biochemical changes associated with ectopic ACTH production have been extensively studied recently, relatively little attention was focused on the morphology of the adrenal cortex and, to our knowledge, the fine structure of the adrenocortical cells in cases of ectopic ACTH syndrome has not been described so far. We report here the electron microscopic findings in the adrenal cortex of a 50-year-old man with a pancreatic apudoma. The patient showed the characteristic clinical and biochemical features of ectopic ACTH syndrome and because of extensive hypercorticism, underwent bilateral adrenalectomy.By light microscopy, the adrenal cortices showed extensive compact cell hyperplasia and lipid depletion. The zona glomerulosa was present in small foci and, except for a few places, fasciculata cells were noted under the fibrous capsule.

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