INFLUENCE OF A HIGHLY PURIFIED THYMUS EXTRACT UPON THE ADRENALS OF GUINEA-PIGS

1955 ◽  
Vol 13 (1) ◽  
pp. 7-10 ◽  
Author(s):  
J. COMSA ◽  
H. LEROUX
Keyword(s):  
Vitamin C ◽  
Adrenal Cortex ◽  
Guinea Pigs ◽  
Relative Weight ◽  
Cholesterol Content ◽  
Transient Increase ◽  
Daily Injection ◽  
Thymus Extract

SUMMARY 1. An attempt has been made to demonstrate the influence of the thymus upon the adrenal in guinea-pigs by daily injection of unphysiological amounts of a highly purified thymus extract. 2. Such injections caused a marked but transient increase in both the vitamin C and cholesterol content of the adrenal. 3. Morphologically, there was a decrease in the weight of the adrenal cortex relative to that of the whole gland, while the relative weight of the medulla increased correspondingly. This change was not transient, but persisted up to 110 days of treatment. 4. It is concluded that the effect of injecting thymus extract is opposite to that of injecting ACTH and gives rise to a resting condition of the adrenal cortex.

scholarly journals High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs

2010 ◽  
Vol 105 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Henriette Frikke-Schmidt ◽  
Pernille Tveden-Nyborg ◽  
Malene Muusfeldt Birck ◽  
Jens Lykkesfeldt
Keyword(s):  
Vitamin C ◽  
Guinea Pigs ◽  
Cholesterol Content ◽  
Dietary Lipid ◽  
Western World ◽  
High Fat ◽  
Vitamin C Deficiency ◽  
Increased Risk ◽  
Oxidation Ratio ◽  
The Brain

Vitamin C deficiency – or hypovitaminosis C defined as a plasma concentration below 23 μm – is estimated to affect hundreds of millions of people in the Western world, in particular subpopulations of low socio-economic status that tend to eat diets of poor nutritional value. Recent studies by us have shown that vitamin C deficiency may result in impaired brain development. Thus, the aim of the present study was to investigate if a poor diet high in fat and cholesterol affects the vitamin C status of guinea pigs kept on either sufficient or deficient levels of dietary ascorbate (Asc) for up to 6 months with particular emphasis on the brain. The present results show that a high-fat and cholesterol diet significantly decreased the vitamin C concentrations in the brain, irrespective of the vitamin C status of the animal (P < 0·001). The brain Asc oxidation ratio only depended on vitamin C status (P < 0·0001) and not on the dietary lipid content. In plasma, the levels of Asc significantly decreased when vitamin C in the diet was low or when the fat/cholesterol content was high (P < 0·0001 for both). The Asc oxidation ratio increased both with low vitamin C and with high fat and cholesterol content (P < 0·0001 for both). We show here for the first time that vitamin C homoeostasis of brain is affected by a diet rich in fat and cholesterol. The present findings suggest that this type of diet increases the turnover of Asc; hence, individuals consuming high-lipid diets may be at increased risk of vitamin C deficiency.

Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis

2018 ◽  
Vol 88 (5-6) ◽  
pp. 263-269
Author(s):  
Seong-Hoon Park ◽  
A Lum Han ◽  
Na-Hyung Kim ◽  
Sae-Ron Shin
Keyword(s):  
Liver Biopsy ◽  
Vitamin C ◽  
Nonalcoholic Steatohepatitis ◽  
Guinea Pigs ◽  
Normal Diet ◽  
High Dose ◽  
Biochemical Tests ◽  
Deficient Diet ◽  
Histological Improvement ◽  
Vit C

Abstract. Background: Vitamin C is a strong antioxidant, and the health effects of vitamin C megadoses have not been validated despite the apparent health benefits. Therefore, the present study sought to confirm the effects of vitamin C megadoses. Materials and Methods : Four groups of six guinea pigs were used. Each group was fed one of the following diets for three weeks: normal diet, methionine choline-deficient diet, methionine choline-deficient diet + vitamin C megadose (MCD + vit C 2.5 g/kg/day), and methionine-choline deficient diet + ursodeoxycholic acid (MCD + UDCA 30 mg/kg/day). The MCD diet was given to induce nonalcoholic steatohepatitis, and UDCA was used to treat nonalcoholic steatohepatitis. Three weeks after initial diet administration, the results of biochemical tests and liver biopsy were compared between the groups. Results: The cytoplasm state was similar in the MCD + vit C and MCD + UDCA groups, exhibiting clearing of the cytoplasm and ballooning degeneration. However, macrovesicular steatosis was not observed in the MCD + vit C group. Aspartate transaminase and alanine transaminase were elevated significantly following vitamin C administration. Conclusions: The present study confirmed that alone vitamin C megadoses are potential remedies for nonalcoholic steatohepatitis, based on the liver biopsy results of guinea pigs that were unable to synthesize vitamin C.

Respiratory Metabolism During Pregnancy in the Guinea Pig

1957 ◽  
Vol 190 (3) ◽  
pp. 425-428 ◽  
Author(s):  
Richard M. Hoar ◽  
William C. Young
Keyword(s):  
Heart Rate ◽  
Oxygen Consumption ◽  
Guinea Pig ◽  
Metabolic Rate ◽  
Adrenal Cortex ◽  
Guinea Pigs ◽  
Sharp Decrease ◽  
Zona Fasciculata ◽  
Respiratory Metabolism ◽  
Morphological Differences

Oxygen consumption and heart rate during pregnancy were measured in untreated, thyroxin-injected and thyroidectomized guinea pigs given I131. From impregnation until parturition, oxygen consumption increased 7.9% in untreated females. The increase continued until 5 days postpartum when a sharp decrease occurred. The increase is not accounted for by growth of the fetal mass. Comparable increases occurred in thyroxin-injected (16.2%) and thyroidectomized (11.9%) females, although the levels throughout were higher and lower, respectively, than in intact females. Heart rate did not increase. On the contrary, statistically significant decreases occurred in the untreated and thyroxin-injected females. Although the mechanism associated with the increased metabolic rate is not known, the possibility of thyroid participation would seem to be excluded. Involvement of the adrenal cortex is suggested by morphological differences in the cells of the zona fasciculata in pregnant and nonpregnant females and by evidence cited from other studies.

INFLUENCE OF A PROLONGED PARTILA DEFICIENCY OF VITAMIN C ON THE RECOVERY OF GUINEA PIGS FROM INJURY TO BONES AND MUSCLES

Nature ◽  
1943 ◽  
Vol 151 (3831) ◽  
pp. 395-396 ◽  
Author(s):  
E. KODICEK ◽  
P. D. F. MURRAY
Keyword(s):  
Vitamin C ◽  
Guinea Pigs

Regulation of apolipoprotein B—containing lipoproteins by vitamin C level and dietary fat saturation in guinea pigs

Metabolism ◽  
1998 ◽  
Vol 47 (7) ◽  
pp. 883-891 ◽  
Author(s):  
Carlos E. Montano ◽  
Maria Luz Fernandez ◽  
Donald J. McNamara
Keyword(s):  
Vitamin C ◽  
Dietary Fat ◽  
Apolipoprotein B ◽  
Guinea Pigs ◽  
Fat Saturation
Sign in / Sign up

Export Citation Format

Share Document