EFFECT OF THYROCALCITONIN AND THYROXINE ON EXPERIMENTAL METASTATIC CALCIFICATION

1968 ◽  
Vol 59 (3) ◽  
pp. 362-370
Author(s):  
G. Côté ◽  
G. Gabbiani ◽  
B. Tuchweber ◽  
C. Déziel
Keyword(s):  
Soft Tissue ◽  
Bone Resorption ◽  
The Other ◽  
Bone Lesions ◽  
Soft Tissue Calcification ◽  
Bilateral Nephrectomy ◽  
Metastatic Calcification ◽  
Tissue Calcification ◽  
Parathyroid Extract ◽  
Lowering Activity

ABSTRACT Experiments on rats indicate that thyrocalcitonin inhibits the metastatic calcification and bone lesions induced by bilateral nephrectomy. In nephrectomized animals, thyroxine does not modify the changes induced by endogenous (uraemic) or exogenous hyperparathyroidism. This is especially noteworthy because this hormone is highly effective against the lesions produced in intact animals by parathyroid extract overdosage. In the absence of the kidneys, thyrocalcitonin decreases calcaemia while thyroxine increases both calcaemia and phosphataemia. Presumably, to be effective against soft-tissue calcification and bone resorption induced by parathyroid extract overdosage, thyroxine requires the presence of the kidney. On the other hand, it appears that the thyroparathyroid apparatus is necessary for the calcium-lowering activity of this hormone.

INHIBITION OF SOFT-TISSUE CALCIFICATION BY PARATHYROID EXTRACT AND CALCIUM

1965 ◽  
Vol 49 (4) ◽  
pp. 603-609 ◽  
Author(s):  
G. Gabbiani ◽  
B. Tuchweber
Keyword(s):  
Vitamin D ◽  
Soft Tissue ◽  
Calcium Acetate ◽  
Phosphate Level ◽  
Soft Tissue Calcification ◽  
Tissue Calcification ◽  
Parathyroid Extract

ABSTRACT Calcium acetate and parathyroid extract do, while vitamin D does not, inhibit the soft-tissue calcification normally induced by calcergy. The inhibition of calcification by the protective substances is associated with, and probably dependent upon, a decreased blood phosphate level.

EFFECT OF SODIUM PYROPHOSPHATE ON EXPERIMENTAL SOFT-TISSUE CALCIFICATION AND HYPERCALCEMIA

1967 ◽  
Vol 45 (6) ◽  
pp. 957-964 ◽  
Author(s):  
B. Tuchweber ◽  
G. Gabbiani
Keyword(s):  
Soft Tissue ◽  
Serum Calcium ◽  
Calcium Acetate ◽  
Sodium Pyrophosphate ◽  
Total Serum ◽  
Soft Tissue Calcification ◽  
Tissue Calcification ◽  
Total Serum Calcium ◽  
Metallic Compounds ◽  
Parathyroid Extract

Sodium pyrophosphate inhibited the cutaneous calcification induced by various metallic compounds in normal rats and in those treated with dihydrotachysterol (DHT). It also caused a. transient decrease in total serum calcium in normal rats and rats treated with calcium acetate, DHT, and parathyroid extract.

Soft Tissue Calcification: A Complication of Vitamin E Injection

PEDIATRICS ◽  
1986 ◽  
Vol 77 (3) ◽  
pp. 382-385
Author(s):  
Mila Barak ◽  
Sylvia Herschkowitz ◽  
Johanan Montag
Keyword(s):  
Vitamin E ◽  
Soft Tissue ◽  
Retinopathy Of Prematurity ◽  
Intramuscular Administration ◽  
Soft Tissue Calcification ◽  
Tissue Calcification ◽  
Premature Babies ◽  
Benign Course

Two cases of gross soft tissue calcification following intramuscular administration of vitamin E in two premature babies are described. The drug was administered for prevention of retinopathy of prematurity. The relation between this complication and both the dosage used and the duration of the treatment is discussed. In spite of the extent of the calcifications, a benign course was observed. Other reports about this complication are reviewed.

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