OVARIAN SENSITIVITY TO OVULATORY STIMULI IN THE ANDROGEN-INDUCED PERSISTENT-OESTROUS RATS

ABSTRACT The ovarian response of adult rats made persistent-oestrus by the postnatal treatment with testosterone propionate was examined by determining the number of ova shed in response to small doses of LH and/or FSH, and placental gonadotrophins (PMSG or HCG). A dose of LH (10 μg/rat) estimated to be equivalent to twice the minimal amount secreted for ovulation in normal rats failed to release a normal complement of ova. The same dose of FSH induced ovulation in 40% of rats with an ova count of 5.7 ± 1.8/rat. Both placental gonadotrophins induced ovulation, although the ova yield was significantly below the normal oestrous control. It is inferred from these findings that the ovarian sensitivity of androgen-sterilized rats is far below that of the normal animals despite the presence of numerous follicles in the ovaries of the persistent-oestrous rats.

Download Full-text

PHYSIOLOGICAL EFFECTS OF THE PINEAL GLAND IN ANDROGEN-STERILIZED FEMALE RATS

Acta Endocrinologica ◽

10.1530/acta.0.0630667 ◽

1970 ◽

Vol 63 (4) ◽

pp. 667-678 ◽

Cited By ~ 4

Author(s):

Russel J. Reiter

Keyword(s):

Pineal Gland ◽

Reproductive Organs ◽

Female Rats ◽

Inhibitory Influence ◽

Light Deprivation ◽

Vaginal Smears ◽

Adult Rats ◽

Androgen Treatment ◽

Postnatal Treatment ◽

Cervical Ganglia

ABSTRACT The influence of early androgen treatment, light deprivation (by blinding), pinealectomy and superior cervical ganglionectomy on the reproductive system of female rats was tested. Early postnatal treatment of rats with testosterone propionate caused adult rats to exhibit the characteristic signs of androgen sterilization; these included polyfollicular ovaries, normal-sized uteri and persistent vaginal cornification. If early androgentreated rats also were blinded the ovaries were smaller in size and contained fewer follicles, the uteri were greatly reduced in size and the incidence of vaginal oestrus was decreased by approximately 50% If in addition to blinding, androgen-sterilized animals were subjected to either removal of the pineal gland or superior cervical ganglia, the reproductive organs and the vaginal smears were indistinguishable from those of testosterone-treated rats with eyes. These data indicate that the inhibitory influence of blinding on the pituitary-ovarian axis was mediated through the sympathetic nervous system and the pineal gland. The restraining influence of light deprivation on the growth of the reproductive organs was not permanent as illustrated by the fact that if these animals were kept to 120 days of age the ovaries and uteri grew to the same level as those of pinealectomized control rats.

Download Full-text

Modification of sexual behaviour in female guinea pigs produced by prenatal and postnatal treatment with testosterone propionate

Animal Behaviour ◽

10.1016/0003-3472(58)90063-0 ◽

1958 ◽

Vol 6 (3-4) ◽

pp. 245

Author(s):

C.H. Phoenix ◽

R.W. Goy ◽

A.A. Gerall ◽

W.C. Young

Keyword(s):

Sexual Behaviour ◽

Guinea Pigs ◽

Testosterone Propionate ◽

Postnatal Treatment

Download Full-text

P-12-4 LTP deficiency in adult rats prenatally exposed to ethanol or hypoxia and its correction by postnatal treatment with nootropic compounds

European Neuropsychopharmacology ◽

10.1016/0924-977x(95)90794-e ◽

1995 ◽

Vol 5 (3) ◽

pp. 418

Author(s):

A.N. Chepkova ◽

S.S. Trofimov ◽

T.A. Gudasheva ◽

R.U. Ostrovskaja ◽

V.G. Skrebitsky

Keyword(s):

Prenatally Exposed ◽

Adult Rats ◽

Postnatal Treatment

Download Full-text

Interval between induced ovulation by intravenous injection of HCG and spontaneous ovulation thereafter in adult rats

The Japanese journal of animal reproduction ◽

10.1262/jrd1955.14.129 ◽

1969 ◽

Vol 14 (4) ◽

pp. 129-138

Author(s):

Katsumi NAKAMURA ◽

Misao KOJIMA ◽

Saburo SINGAI ◽

Toshima NOBUNAGA

Keyword(s):

Intravenous Injection ◽

Adult Rats ◽

Induced Ovulation

Download Full-text

Learning deficits produced by postnatal treatment of adult rats with chlorpromazine.

The Japanese Journal of Pharmacology ◽

10.1016/s0021-5198(19)53361-3 ◽

1980 ◽

Vol 30 ◽

pp. 72

Author(s):

Tetsu Hayashi ◽

Sakutaro Tadokoro

Keyword(s):

Adult Rats ◽

Learning Deficits ◽

Postnatal Treatment

Download Full-text

EFFECTS OF TESTOSTERONE MEDIATED OR MODULATED BY PITUITARY FACTORS

Journal of Endocrinology ◽

10.1677/joe.0.0670071 ◽

1975 ◽

Vol 67 (1) ◽

pp. 71-79 ◽

Cited By ~ 8

Author(s):

P. DE MOOR ◽

M. ADAM-HEYLEN ◽

H. VAN BAELEN ◽

G. VERHOEVEN

Keyword(s):

Body Weight ◽

Testosterone Propionate ◽

Total Body Weight ◽

Seminal Vesicles ◽

Female Rats ◽

Male Rats ◽

Intact Male ◽

Adult Rats ◽

Organ Weights ◽

Total Body

SUMMARY Adult rats of both sexes were either gonadectomized or hypophysectomized and gonadectomized. Three to eight weeks later they were treated for 14 consecutive days with oil or with 75 or 200 μg testosterone propionate (TP) per 100 g body weight. The animals were killed and for each sex the gonadectomized animals were compared with the hypophysectomized-gonadectomized animals as far as their NADPH- and NADH-dependent 3α-hydroxysteroid dehydrogenases (3α-HSD) in renal microsomes, transcortin levels in serum and five organ weights relative to total body weight were concerned. For two of the latter, i.e. the relative kidney and prostatic weights, no significant differences were found. Transcortin levels, relative adrenal weights and renal NADPH-dependent 3α-HSD activities were higher in oil-treated gonadectomized animals than in oil-treated hypophysectomized-gonadectomized animals. The opposite was found for the relative weights of uterus and seminal vesicles and renal NADH-dependent 3α-HSD activities. These differences between gonadectomized and hypophysectomized-gonadectomized animals disappeared after TP treatment as far as transcortin levels were concerned but remained for the five other parameters. After gonadectomy sexual differences subsisted for all parameters studied. But whereas intact male rats had higher NADH-dependent 3α-HSD activities than female rats the opposite was found after gonadectomy. After gonadectomy plus hypophysectomy the between sex differences disappeared as far as transcortin levels were concerned but remained in the other parameters studied.

Download Full-text

Sympathetic pharmacological denervation in ageing rats: effects on ovulatory response and follicular population

Reproduction Fertility and Development ◽

10.1071/rd07075 ◽

2007 ◽

Vol 19 (8) ◽

pp. 954 ◽

Cited By ~ 13

Author(s):

Rebeca Chávez-Genaro ◽

Paula Lombide ◽

Roberto Domínguez ◽

Patricia Rosas ◽

Francisco Vázquez-Cuevas

Keyword(s):

Young Adult ◽

Combined Treatment ◽

Ovarian Response ◽

Sympathetic Denervation ◽

Progressive Reduction ◽

Adult Rats ◽

Reproductive Senescence ◽

Noradrenergic Innervation ◽

Old Rats ◽

Control Adult

The present study analyses the participation of ovarian innervation during reproductive senescence. We use the model of acute peripheral pharmacological sympathetic denervation with guanethidine in young (3 months old), middle-aged (12 months old) or old (18 months old) rats with spontaneous or induced ovulation. Ovarian levels of norepinephrine (NE) were measured by HPLC and the oestrous cycle, the number of ovulating animals and the percentage of atretic follicles were also assessed. Aged animals showed a progressive reduction in ovulatory capacity and an increase in ovarian NE content. Acute denervation increased the percentage of healthy follicles in 12- and 18-month-old rats compared with control adult animals. Combined treatment of denervation plus stimulation with gonadotrophins doubled the number of ova shed in young adult rats and restablished a partial ovulation in 12-month-old rats. The results suggest that ovarian noradrenergic innervation plays a modulator role in ovarian physiology during the ageing ovary process. The action of ovarian noradrenergic innervation seems to be associated with folliculogenesis and the ovarian response to gonadotrophins.

Download Full-text