THE EFFECT OF CLOMIPHENE ON URINARY GONADOTROPHINS IN INFERTILE MEN

1972 ◽  
Vol 70 (4) ◽  
pp. 654-664 ◽  
Author(s):  
Peter Christiansen
Keyword(s):  
Side Effects ◽  
Luteinizing Hormone ◽  
Clomiphene Citrate ◽  
Follicle Stimulating Hormone ◽  
Urine Samples ◽  
Pronounced Increase ◽  
Infertile Men ◽  
Stimulating Hormone

ABSTRACT In order to study the effect on urinary hypophyseal gonadotrophins as measured by specific bioassays, 19 infertile men aged 26 to 47 years, average 30.8, were treated with clomiphene citrate (Clomivid®) 50 mg daily for 30 days. During the last 8 days of treatment 24 hour urine samples were collected daily for the determination of total hypophyseal gonadotrophins (HG), follicle stimulating hormone (FSH) and luteinizing hormone (LH). HG, FSH and LH rose equally to an average of 3 times the control values, the increase being highly significant statistically (P < 0.001). The most pronounced increase was observed in the cases with the lowest control values. Only one patient failed to respond. No side effects due to the drug were observed.

Glycerol prevents loss of immunoreactive follicle-stimulating hormone and luteinizing hormone from frozen urine

1983 ◽  
Vol 98 (3) ◽  
pp. 381-384 ◽  
Author(s):  
J. H. Livesey ◽  
H. K. Roud ◽  
M. G. Metcalf ◽  
R. A. Donald
Keyword(s):  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Urine Samples ◽  
Initial Value ◽  
Menopausal Women ◽  
Post Menopausal ◽  
Stimulating Hormone

First morning urine samples were collected from both menstruant and post-menopausal women and stored at −25 °C. Immunoreactive FSH disappeared from these samples (t½ = 30 days), ultimately stabilizing at about 20% of the initial value. The loss was more rapid at −20 °C and less rapid at −55 °C and +4°C. Immunoreactive LH was also lost from frozen urine, but more slowly than FSH. The addition of glycerol to urine (0·52 mol/l) stored at −25 °C prevented loss of immunoreactive FSH and LH for at least 105 days.

Myoglobin-silver reduced graphene oxide nanocomposite stochastic biosensor for the determination of luteinizing hormone and follicle-stimulating hormone from saliva samples

2020 ◽  
Vol 412 (21) ◽  
pp. 5191-5202
Author(s):  
Livia Alexandra Dinu Gugoasa ◽  
Raluca-Ioana Stefan-van Staden ◽  
Jacobus Frederick van Staden ◽  
Maria Coros ◽  
Stela Maria Pruneanu
Keyword(s):  
Graphene Oxide ◽  
Luteinizing Hormone ◽  
Reduced Graphene Oxide ◽  
Follicle Stimulating Hormone ◽  
Reduced Graphene ◽  
Stimulating Hormone
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