Sex steroids and steroid binding proteins in female alcoholic liver disease

Abstract. Blood levels of sex steroids and steroid binding proteins were measured in 21 females with alcoholic liver disease and in age matched healthy controls and correlated to type and severity of histological changes in concomitant liver biopsies. In patients with liver disease androstenedione levels were high in contrast to the low levels of dehydroepiandrosterone (DHA), dehydroepiandrosterone sulphate (DHAS) and albumin. Normal levels of testosterone and total oestrone were found in the patients. SHBG varied independently of albumin and decreased SHBG levels were found in patients with steatosis. DHA, DHAS and albumin levels were negatively correlated to the total biopsy score and a positive correlation was found between DHAS and albumin. The higher levels of androstenedione were found in patients with mild histological lesions. The findings are thought to reflect alcohol-induced changes in hepatic as well as in adrenocortical activity.

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The Association of Endogenous Sex Steroids and Sex Steroid Binding Proteins with Mammographic Density: Results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study

American Journal of Epidemiology ◽

10.1093/aje/kwi286 ◽

2005 ◽

Vol 162 (9) ◽

pp. 826-834 ◽

Cited By ~ 71

Author(s):

Gail A. Greendale ◽

Shana L. Palla ◽

Giske Ursin ◽

Gail A. Laughlin ◽

Carolyn Crandall ◽

...

Keyword(s):

Mammographic Density ◽

Sex Steroids ◽

Binding Proteins ◽

Sex Steroid ◽

Postmenopausal Estrogen ◽

Steroid Binding Proteins ◽

Steroid Binding ◽

Density Study ◽

Density Results

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Sex steroids and steroid binding proteins in primary biliary cirrhosis

Journal of Steroid Biochemistry ◽

10.1016/0022-4731(89)90217-3 ◽

1989 ◽

Vol 32 (3) ◽

pp. 427-431 ◽

Cited By ~ 10

Author(s):

Sten Eriksson ◽

Kjell Carlström ◽

Gunnar Rannevik

Keyword(s):

Primary Biliary Cirrhosis ◽

Sex Steroids ◽

Binding Proteins ◽

Biliary Cirrhosis ◽

Steroid Binding Proteins ◽

Steroid Binding

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Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100051001 ◽

1974 ◽

Vol 32 ◽

pp. 198-199

Author(s):

Odell T. Minick ◽

Hidejiro Yokoo

Keyword(s):

Liver Disease ◽

Alcoholic Liver Disease ◽

Special Interest ◽

Structural Variations ◽

Mitochondrial Alterations ◽

The Matrix ◽

Crystalloid Inclusions ◽

Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

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MEASUREMENT OF STEROID BINDING PROTEINS

Acta Endocrinologica ◽

10.1530/acta.0.065s104 ◽

1970 ◽

Vol 65 (1_Suppl) ◽

pp. S104-S121 ◽

Cited By ~ 24

Author(s):

E. E. Baulieu ◽

J. P. Raynaud ◽

E. Milgrom

Keyword(s):

Kinetic Parameters ◽

Binding Proteins ◽

Binding Specificity ◽

Binding Parameters ◽

Target Organs ◽

Biological Mixtures ◽

Steroid Binding Proteins ◽

Steroid Binding ◽

Steroid Binding Protein

ABSTRACT A brief review of the characteristics of steroid binding proteins found in the plasma and in some target organs is presented, followed by some general remarks on binding »specificity« and binding parameters. Useful techniques for measuring binding parameters at equilibrium are reported, both those which keep the equilibrium intact and those which implicate its disruption. A concept is developed according to which the determination of a specific steroid binding protein is based on the »differential dissociation« of the several steroid binding complexes present in most biological mixtures. Methods which allow determination of the kinetic parameters of the binding systems are also presented. Various representations of the binding and therefore different modes of graphic representation and calculation are discussed, including the recent »proportion graph« method.

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