Extracellular glucose alters mesenchymal stromal cell growth and differentiation

2013 ◽  
Author(s):  
Anna-Reeta Virta ◽  
Kaisa K Ivaska
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Extracellular Glucose ◽  
Cell Growth And Differentiation

Inhibition of U266 cell growth by human mesenchymal stromal cell-mediated small interfering RNA silencing of interleukin-6

Cytotherapy ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. S33
Author(s):  
H. Teoh ◽  
P. Chong ◽  
Z. Sekawi ◽  
M. Abdullah ◽  
C. Leong ◽  
...  
Keyword(s):  
Cell Growth ◽  
Interleukin 6 ◽  
Mesenchymal Stromal Cell ◽  
Rna Silencing ◽  
Small Interfering Rna ◽  
Stromal Cell ◽  
U266 Cell ◽  
Interfering Rna

Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro

Cytotherapy ◽  
2013 ◽  
Vol 15 (12) ◽  
pp. 1469-1483 ◽  
Author(s):  
Sarah Griffiths ◽  
Priya R. Baraniak ◽  
Ian B. Copland ◽  
Robert M. Nerem ◽  
Todd C. McDevitt
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Platelet ◽  
Platelet Lysate ◽  
Multipotent Mesenchymal Stromal Cell ◽  
High Passage ◽  
Human Platelet Lysate

Albumin-Associated Compounds in Serum-Free Media Formulations Affect Mesenchymal Stromal Cell Growth

Cytotherapy ◽  
2016 ◽  
Vol 18 (6) ◽  
pp. S153
Author(s):  
K. Tan ◽  
K. Teo ◽  
A. Chen ◽  
S. Reuveny ◽  
S. Oh
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Serum Free ◽  
Free Media

scholarly journals Modelling mesenchymal stromal cell growth in a packed bed bioreactor with a gas permeable wall

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0202079 ◽  
Author(s):  
Michael J. Osiecki ◽  
Sean D. L. McElwain ◽  
William B. Lott
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Packed Bed ◽  
Permeable Wall ◽  
Packed Bed Bioreactor

scholarly journals The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal- cell-independent expansion and differentiation of human fetal pro-B cells in vitro

Blood ◽  
1996 ◽  
Vol 87 (5) ◽  
pp. 1881-1890 ◽  
Author(s):  
R Namikawa ◽  
MO Muench ◽  
JE de Vries ◽  
MG Roncarolo
Keyword(s):  
Bone Marrow ◽  
B Cells ◽  
Cell Growth ◽  
B Cell ◽  
Stromal Cells ◽  
Stromal Cell ◽  
Mouse Bone Marrow ◽  
Flt3 Ligand ◽  
Cell Growth And Differentiation

Abstract The effects of a novel cytokine FLK2/FLT3 ligand (FL) on human fetal bone marrow-derived CD34+CD19+ pro-B cells were analyzed in a stromal- cell-independent, serum-deprived culture system. FL, like interleukin-3 (IL-3), synergized with IL-7 in promoting pro-B cell growth, and differentiation of these cells into CD34-CD19+clgM+slgM- pre-B cells, whereas a small proportion of these cells even differentiate into more mature slgM+ B cells. In contrast, KIT ligand (KL) and granulocyte- macrophage colony-stimulating factor (GM-CSF) were ineffective in promoting IL-7-dependent pro-B cell growth and differentiation. Maximal levels of pro-B cell expansion, generally resulting in 15- to 30-fold increases in cellularity, were obtained in cultures supplemented with optimal doses of FL + IL-7 + IL-3. The addition of mouse bone marrow stromal cells further enhanced the proliferation and differentiation of pro-B cells obtained in the presence of these three cytokines. Under these conditions, cultures could be maintained for more than 4 weeks, and in general 40- to 50-fold increases in cell numbers were observed by 3 weeks of culture. The percentages of clgM+ and slgM+ B cells increased 1.5- to 3-fold and 2-fold, respectively, suggesting that stromal cells may provide additional costimulatory signals for human B- cell growth and differentiation that are different from IL-7, IL-3, and FL. Collectively, our results indicate that FL, in contrast to KL, strongly promotes long-term expansion and differentiation of human pro- B cells in the presence of IL-7 or in combination of IL-7 and IL-3, which is a novel property of this hematopoietic growth factor.

Control of Cell Growth and Differentiation during Early B-cell Development by Stromal Cell Molecules

1989 ◽  
Vol 54 (0) ◽  
pp. 171-174 ◽  
Author(s):  
S.-I. Nishikawa ◽  
S.-I. Hayashi ◽  
M. Ogawa ◽  
T. Kunisada ◽  
S. Nishikawa ◽  
...  
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Stromal Cell ◽  
Cell Development ◽  
B Cell Development ◽  
Cell Growth And Differentiation

scholarly journals Potency testing of mesenchymal stromal cell growth expanded in human platelet lysate from different human tissues

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
R. Fazzina ◽  
P. Iudicone ◽  
D. Fioravanti ◽  
G. Bonanno ◽  
P. Totta ◽  
...  
Keyword(s):  
Cell Growth ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell ◽  
Human Platelet ◽  
Platelet Lysate ◽  
Human Tissues ◽  
Human Platelet Lysate

scholarly journals The characteristics of rabbit and rat mesenchymal stromal cell growth and attachment to mesh used in hernia repair

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Diana L. Fagan ◽  
Melissa Lydic ◽  
Hazel Marie ◽  
Paul Fredette ◽  
Jeremy Heffner ◽  
...  
Keyword(s):  
Cell Growth ◽  
Hernia Repair ◽  
Mesenchymal Stromal Cell ◽  
Stromal Cell
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