The upper two third of the reference interval of the serum calcium level is required for the optimal increase in lumbar bone mineral density by bisphosphonate and active vitamin D3 analogue for osteoporosis

2016 ◽  
Author(s):  
Mayuko Kinoshita ◽  
Muneaki Ishijima ◽  
Haruka Kaneko ◽  
Liu Lizu ◽  
Ryo Sadatsuki ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Vitamin D3 ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Reference Interval ◽  
Lumbar Bone Mineral Density ◽  
Active Vitamin ◽  
Mineral Density

scholarly journals Early diagnosis of violation of mineral metabolism, as a way of primary and secondary prevention of fractures Arctic army groupings

2018 ◽  
Vol 20 (4) ◽  
pp. 45-51
Author(s):  
V V Tyrenko ◽  
D S Aganov ◽  
M M Toporkov ◽  
E N Tsygan ◽  
S G Bologov
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Mineral Metabolism ◽  
Reference Interval ◽  
Essential Elements ◽  
Mineral Density ◽  
The North ◽  
Hair Samples ◽  
Vitamin D3 Deficiency

The main challenges leading to the decrease of bone mineral metabolism in the conditions of the North are covered. The presented results of a study of 29 soldiers serving in the extreme conditions of the North, to study the mineral density of bone tissue in the distal forearm. Revealed a significant decrease in bone mineral density, as well as a deficiency of essential elements in this cohort. So, when densitometric training of servicemen serving in the North, the average Z-test was 0±1,8 SD, the change in bone mass corresponded to the Z-test less than -2 SD, was determined at 31,03%. Vitamin D3 deficiency was detected in 96,5% of cases. Analysis of the bio-element state of the hair revealed a deviation of the reference interval in 100% of military personnel, a decrease in essential elements: cobalt, selenium, magnesium, vanadium and an increase in the level of barium, bromine, arsenic, as well as caesium. The interrelation of the elemental status and bone mineral density is revealed. 100% of the examined hair samples showed a significant decrease in the level of cobalt, selenium and iodine. (p0,05) a decrease in boron, magnesium, calcium, vanadium (p0,05) and a significant increase in chromium, manganese, and copper. A quantitative study of toxic elements revealed a significant (p0,05) increase in mercury, rubidium, strontium, and caesium. A correlation was established between the Z-test and the level of vitamin D3, body mass index and dynamometer. The data obtained determine the required level of trace elements in order to prevent disturbances of mineral metabolism and bone loss.

scholarly journals Association of Genetic Variants Related to Serum Calcium Levels with Reduced Bone Mineral Density

2019 ◽  
Vol 105 (3) ◽  
pp. e328-e336 ◽  
Author(s):  
Gloria Hoi-Yee Li ◽  
Cassianne Robinson-Cohen ◽  
Shivani Sahni ◽  
Philip Chun-Ming Au ◽  
Kathryn Choon-Beng Tan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Serum Calcium ◽  
Genetic Predisposition ◽  
Calcium Level ◽  
Serum Calcium Level ◽  
Whole Body ◽  
Mineral Density

Abstract Context The role of serum calcium in bone metabolism is unknown, even though calcium/vitamin D supplementations have been widely used and are expected to improve bone health. We aim to determine the independent role of serum calcium in bone mineral density (BMD). Design and setting Two epidemiological analyses with 5478 and 5556 participants from the National Health and Nutrition Examination Survey (NHANES) 2003 to 2006 and the Hong Kong Osteoporosis Study (HKOS) to evaluate the cross-sectional association of serum calcium with BMD. Two-sample Mendelian randomization (MR) studies using genetic variations as instrumental variables to infer causality. Summary statistics of genome-wide association study of serum calcium (N = 39 400) and lifelong whole-body BMD (N = 66 628) were used. Main outcome measure BMD measured by dual-energy X-ray absorptiometry Results In NHANES 2003–6 and HKOS, each standard deviation (SD) increase in serum calcium was significantly associated with 0.036–0.092 SD decrease in BMD at various sites (all P < .05). In multivariable inverse-variance weighted MR analysis, genetic predisposition to higher serum calcium level was inversely associated with whole-body BMD after adjustment for serum parathyroid hormone, vitamin D, and phosphate (–0.431 SD per SD increase in serum calcium; 95% CI: –0.773 to –0.089, P = .014). Similar estimates were obtained in sensitivity analyses. Conclusions Our study reveals that genetic predisposition to higher serum calcium level per se may have a negative impact on bone metabolism. Whether increased serum calcium caused by calcium/vitamin D supplementations would have the same negative effect on bone remains unknown, which warrants further investigation. In addition to other adverse clinical outcomes, careful use of high-dose supplementations is required.

Effect of active vitamin D3 on reduction in Bone Mineral Density after oophorectomy

1992 ◽  
Vol 17 ◽  
pp. 183
Author(s):  
Y. Seimiya ◽  
J-T. Chen ◽  
Y. Hirai ◽  
M. Shiraki
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Active Vitamin ◽  
Mineral Density

scholarly journals Synthesis of 2α-Heteroarylalkyl Active Vitamin D3 with Therapeutic Effect on Enhancing Bone Mineral Density in Vivo

2013 ◽  
Vol 4 (7) ◽  
pp. 671-674 ◽  
Author(s):  
Miki Matsuo ◽  
Asami Hasegawa ◽  
Masashi Takano ◽  
Hiroshi Saito ◽  
Shinji Kakuda ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Therapeutic Effect ◽  
Bone Mineral ◽  
Vitamin D3 ◽  
Active Vitamin ◽  
Mineral Density

Relationship between serum calcium levels and bone mineral density in liver transplant receipients

2001 ◽  
Vol 120 (5) ◽  
pp. A564-A564
Author(s):  
K ISLAM ◽  
S CREECH ◽  
R SOKHI ◽  
R KONDAVEETI ◽  
A NADIR ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Transplant ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mineral Density

scholarly journals P114 Effect of vitamin D on parathyroid hormone, serum calcium and bone mineral density in patients with primary hyperparathyroidism being managed conservatively

Rheumatology ◽  
2021 ◽  
Vol 60 (Supplement_1) ◽  
Author(s):  
Mahrukh Khalid ◽  
Vismay Deshani ◽  
Khalid Jadoon
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mineral Density ◽  
Neck Of Femur ◽  
Vitamin D Levels ◽  
Significant Difference

Abstract Background/Aims  Vitamin D deficiency is associated with more severe presentation of primary hyperparathyroidism (PTHP) with high parathyroid hormone (PTH) levels and reduced bone mineral density (BMD). We analyzed data to determine if vitamin D levels had any impact on PTH, serum calcium and BMD at diagnosis and 3 years, in patients being managed conservatively. Methods  Retrospective analysis of patients presenting with PHPT. Based on vitamin D level at diagnosis, patients were divided into two groups; vitamin D sufficient (≥ 50 nmol/L) and vitamin D insufficient (≤ 50 nmol/L). The two groups were compared for age, serum calcium and PTH levels at diagnosis and after mean follow up of 3 years. BMD at forearm and neck of femur (NOF) was only analyzed in the two groups at diagnosis, due to lack of 3 year’s data. Results  There were a total of 93 patients, 17 males, mean age 70; range 38-90. Mean vitamin D level was 73.39 nmol/L in sufficient group (n = 42) and 34.48 nmol/L in insufficient group (n = 40), (difference between means -38.91, 95% confidence interval -45.49 to -32.33, p < 0.0001). There was no significant difference in age, serum calcium and PTH at the time of diagnosis. After three years, there was no significant difference in vitamin D levels between the two groups (mean vitamin D 72.17 nmol/L in sufficient group and 61.48 nmol/L in insufficient group). Despite rise in vitamin D level in insufficient group, no significant change was observed in this group in PTH and serum calcium levels. BMD was lower at both sites in vitamin D sufficient group and difference was statistically significant at NOF. Data were analyzed using unpaired t test and presented as mean ± SEM. Conclusion  50% of patients presenting with PHPT were vitamin D insufficient at diagnosis. Vitamin D was adequately replaced so that at 3 years there was no significant difference in vitamin D status in the two groups. Serum calcium and PTH were no different in the two groups at diagnosis and at three years, despite rise in vitamin D levels in the insufficient group. Interestingly, BMD was lower at forearm and neck of femur in those with sufficient vitamin D levels and the difference was statistically significant at neck of femur. Our data show that vitamin D insufficiency does not have any significant impact on PTH and calcium levels and that vitamin D replacement is safe in PHPT and does not impact serum calcium and PTH levels in the short term. Lower BMD in those with adequate vitamin D levels is difficult to explain and needs further research. Disclosure  M. Khalid: None. V. Deshani: None. K. Jadoon: None.

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