Human foetal adrenal gland development and effects of maternal smoking

2015 ◽  
Author(s):  
Zoe C Johnston ◽  
Panagiotis Filis ◽  
Michelle Bellingham ◽  
Peter J O'Shaughnessy ◽  
Paul A Fowler
Toxicology ◽  
2021 ◽  
pp. 152932
Author(s):  
Qiang Xu ◽  
Quanxu Chen ◽  
Liben Lin ◽  
Pu Zhang ◽  
Zengqiang Li ◽  
...  

2019 ◽  
Vol 8 ◽  
pp. 60-65 ◽  
Author(s):  
Adrien Levasseur ◽  
Typhanie Dumontet ◽  
Antoine Martinez

2007 ◽  
Vol 104 (46) ◽  
pp. 18205-18210 ◽  
Author(s):  
D. Chida ◽  
S. Nakagawa ◽  
S. Nagai ◽  
H. Sagara ◽  
H. Katsumata ◽  
...  

2002 ◽  
Vol 22 (3) ◽  
pp. 946-952 ◽  
Author(s):  
David J. Zammit ◽  
Stuart P. Berzins ◽  
Jason W. Gill ◽  
Elise S. Randle-Barrett ◽  
Louise Barnett ◽  
...  

ABSTRACT Thymic shared antigen 1 (TSA-1) is a plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development.


Sign in / Sign up

Export Citation Format

Share Document