In vivo imaging reveals prostate pathology in the PTEN knockout murine model of prostate cancer

2016 ◽  
Author(s):  
Alysha Bhatti ◽  
Almeida Gilberto Serrano de ◽  
Serena Tommasini Ghelfi ◽  
Alwyn Dart ◽  
Anabel Varela-Carver ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Model ◽  
In Vivo Imaging

scholarly journals MP37-10 11B6 MAB: APPLICATIONS FOR PROSTATE CANCER STAGING, INTRA-OPERATIVE GUIDANCE AND EVALUATION OF TREATMENT BY IN VIVO IMAGING OF HK2

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Daniel Thorek ◽  
Katharina Braun ◽  
Jason Lewis ◽  
Peter Scardino ◽  
Hans Lilja ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Cancer Staging ◽  
Prostate Cancer Staging

scholarly journals Anti-tumor immunological response induced by cryoablation and anti-CTLA-4 antibody in an in vivo RM-1 cell prostate cancer murine model

Neoplasma ◽  
2014 ◽  
Vol 61 (06) ◽  
pp. 659-671 ◽  
Author(s):  
F. LI ◽  
Z. GUO ◽  
H. YU ◽  
X. ZHANG ◽  
T. SI ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Murine Model ◽  
Immunological Response

scholarly journals In Vivo Imaging of Prostate Cancer Using [68Ga]-Labeled Bombesin Analog BAY86-7548

2013 ◽  
Vol 19 (19) ◽  
pp. 5434-5443 ◽  
Author(s):  
Esa Kähkönen ◽  
Ivan Jambor ◽  
Jukka Kemppainen ◽  
Kaisa Lehtiö ◽  
Tove J. Grönroos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging

545 PEPTIDE RECEPTOR TARGETING IS SUPERIOR TO METABOLIC TARGETING FOR IN VIVO IMAGING OF HUMAN PROSTATE CANCER XENOGRAFTS

2010 ◽  
Vol 183 (4S) ◽  
Author(s):  
Rogier P.J. Schroeder ◽  
Saskia C. Berndsen ◽  
Corine de Ligt ◽  
Susanne Reneman ◽  
Eric P. Krenning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Receptor Targeting ◽  
Peptide Receptor ◽  
Metabolic Targeting

IN VIVO IMAGING OF LUCIFERASE-LABELED HUMAN PROSTATE CANCER CELLS, PC-3MM2, IN ORTHOTOPIC NUDE MOUSE MODELS

2008 ◽  
Vol 179 (4S) ◽  
pp. 425-425
Author(s):  
Sertac Yazici ◽  
Erik Busby ◽  
Sun Jin Kim ◽  
Isaiah J Fidler
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Mouse Models ◽  
Nude Mouse ◽  
In Vivo Imaging ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals Tropoelastin: an in vivo imaging marker of dysfunctional matrix turnover during abdominal aortic dilation

2019 ◽  
Author(s):  
Begoña Lavin ◽  
Sara Lacerda ◽  
Marcelo E Andia ◽  
Silvia Lorrio ◽  
Robert Bakewell ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Aortic Aneurysm ◽  
Murine Model ◽  
In Vivo Imaging ◽  
Gene Knockout ◽  
Aortic Dilation ◽  
Luminal Diameter ◽  
Enhanced Mri ◽  
Abdominal Aortic

Abstract Aims Dysfunctional matrix turnover is present at sites of abdominal aortic aneurysm (AAA) and leads to the accumulation of monomeric tropoelastin rather than cross-linked elastin. We used a gadolinium-based tropoelastin-specific magnetic resonance contrast agent (Gd-TESMA) to test whether quantifying regional tropoelastin turnover correlates with aortic expansion in a murine model. The binding of Gd-TESMA to excised human AAA was also assessed. Methods and results We utilized the angiotensin II (Ang II)-infused apolipoprotein E gene knockout (ApoE−/−) murine model of aortic dilation and performed in vivo imaging of tropoelastin by administering Gd-TESMA followed by late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) and T1 mapping at 3 T, with subsequent ex vivo validation. In a cross-sectional study (n = 66; control = 11, infused = 55) we found that Gd-TESMA enhanced MRI was elevated and confined to dilated aortic segments (control: LGE=0.13 ± 0.04 mm2, control R1= 1.1 ± 0.05 s−1 vs. dilated LGE =1.0 ± 0.4 mm2, dilated R1 =2.4 ± 0.9 s−1) and was greater in segments with medium (8.0 ± 3.8 mm3) and large (10.4 ± 4.1 mm3) compared to small (3.6 ± 2.1 mm3) vessel volume. Furthermore, a proof-of-principle longitudinal study (n = 19) using Gd-TESMA enhanced MRI demonstrated a greater proportion of tropoelastin: elastin expression in dilating compared to non-dilating aortas, which correlated with the rate of aortic expansion. Treatment with pravastatin and aspirin (n = 10) did not reduce tropoelastin turnover (0.87 ± 0.3 mm2 vs. 1.0 ± 0.44 mm2) or aortic dilation (4.86 ± 2.44 mm3 vs. 4.0 ± 3.6 mm3). Importantly, Gd-TESMA-enhanced MRI identified accumulation of tropoelastin in excised human aneurysmal tissue (n = 4), which was confirmed histologically. Conclusion Tropoelastin MRI identifies dysfunctional matrix remodelling that is specifically expressed in regions of aortic aneurysm or dissection and correlates with the development and rate of aortic expansion. Thus, it may provide an additive imaging marker to the serial assessment of luminal diameter for surveillance of patients at risk of or with established aortopathy.

scholarly journals Contrast-Enhanced In Vivo Imaging of Breast and Prostate Cancer Cells by MRI

Cell Cycle ◽  
2005 ◽  
Vol 5 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Olga Rodriguez ◽  
Stanley Fricke ◽  
Christopher Chien ◽  
Luis Dettin ◽  
John VanMeter ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vivo Imaging ◽  
Prostate Cancer Cells ◽  
Contrast Enhanced ◽  
Breast And Prostate Cancer

scholarly journals M13-templated magnetic nanoparticles for targeted in vivo imaging of prostate cancer

2012 ◽  
Vol 7 (10) ◽  
pp. 677-682 ◽  
Author(s):  
Debadyuti Ghosh ◽  
Youjin Lee ◽  
Stephanie Thomas ◽  
Aditya G. Kohli ◽  
Dong Soo Yun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Magnetic Nanoparticles ◽  
In Vivo Imaging

scholarly journals In vivo imaging of prostate cancer using an anti-PSMA scFv fragment as a probe

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Claire Mazzocco ◽  
Giulio Fracasso ◽  
Coralie Germain-Genevois ◽  
Nathalie Dugot-Senant ◽  
Mariangela Figini ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
In Vivo Imaging ◽  
Scfv Fragment
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