Serum 25-Hydroxy vitamin D levels and insulin resistance in polycystic ovary syndrome

Background: The polycystic ovary syndrome (PCOS) is one of the commonest human endocrinopathies and is increasingly recognized as a variant of the metabolic syndrome in women with the characteristic features of insulin resistance, central obesity, impaired glucose metabolism, dyslipidemia, and hypertension.Methods: This study is mainly focused on study of parameters like gonadotropin hormonal profile, serum vitamin D and calcium levels in polycystic ovary disease (PCOD). The study comprised 45 clinically proven polycystic ovary disease patients in the age range of 19-34 years. The biochemical estimations carried out in the study were – Fasting Blood sugar, LH, FSH, prolactin, 25- OH vitamin D and calcium along with anthropometric data. The values obtained were compared with age matched equal number of healthy control female subjects from the same population.Results: The serum concentration of calcium and vitamin D levels are decreased significantly (P <0.001) when compared to controls. Insulin resistance is predominantly seen in PCOS subjects. The study outlines the importance of insulin resistance, dyslipidemia, decreased serum calcium and vitamin D levels in PCOS subjects may be a cause for the progression of polycystic ovary syndrome.Conclusions: In the present study vitamin D deficiency is highly prevalent in PCOS women from this area compared to control women. We also relations of vitamin D status with insulin sensitivity, HDL-C, and C-reactive protein in PCOS patients, which support the increasing evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women. A high prevalence of vitamin D deficiency and low calcium levels were observed in PCOS women from our population when compared to controls. Insulin resistance was predominantly seen in PCOS subjects when compared with controls, indicating the association of vitamin D levels with insulin resistance.

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Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Journal of the Faculty of Medicine Baghdad ◽

10.32007/jfacmedbagdad.60212 ◽

2018 ◽

Vol 60 (2) ◽

pp. 93-97

Author(s):

Rana A. Hamdi ◽

Zina H. Abdul-Qahar ◽

Ekhlas J. Kadhum ◽

Fatin A. Alsaeed

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Free Testosterone ◽

Serum Glucose ◽

Fasting Serum ◽

Ovary Syndrome ◽

Fasting Serum Glucose ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women ofreproductive age with primary features of infertility, menstrual irregularity, and clinical or biochemicalevidence of hyperandrogenism (hirsutism, acne and high androgen level). Vitamin D has a role in thedevelopment of metabolic and endocrine abnormalities in PCOS mediated by insulin resistance.Objective: Measure serum 25-hydroxy vitamin D levels in women with polycystic ovary syndrome andcompare their levels with age and body mass index matched healthy controls. Also, assess thecorrelation between insulin resistance and 25-hydroxy vitamin D among women with PCOS.Subjects and Methods: Eighty eight women were involved in this study with age range (18-34 years).Subjects were divided into two groups: Group 1- forty five women with PCOS and Group 2- forty threewomen without PCOS (as controls).Serum 25-hydroxy vitamin D, insulin, free testosterone, Luteinizing hormone (LH), Follicle stimulatinghormone (FSH) were measured by enzyme linked immunosorbent assay (ELISA), while serum calciumand fasting serum glucose were measured by spectrophotometer.Results: Significant increase in mean value of fasting serum glucose, insulin, homeostatic modelassessment of insulin resistance (HOMA-IR), LH, LH/FSH ratio, and free testosterone with significantdecrease in mean value of serum FSH, 25-hydroxy vitamin D, and calcium for patients with PCOScomparing to age and body mass index match controls. Additionally, significant negative correlationswere found between serum 25-hydroxy vitamin D levels with fasting serum glucose (r= -0.484, p=0.01),fasting serum insulin (r= -0.422, p=0.04), and HOMA-IR (r= -0.542, p=0.0001) in women with PCOS.Conclusion: Vitamin D has a role in metabolic and hormonal disturbance seen in PCOS through impactof vitamin D on insulin releasing and function.

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Vitamin D Levels in Women with Polycystic Ovary Syndrome: A Population-Based Study

Nutrients ◽

10.3390/nu11112831 ◽

2019 ◽

Vol 11 (11) ◽

pp. 2831 ◽

Cited By ~ 1

Author(s):

Johanna Lumme ◽

Sylvain Sebert ◽

Paula Pesonen ◽

Terhi Piltonen ◽

Marjo-Riitta Järvelin ◽

...

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Population Based ◽

Low Grade ◽

Ovary Syndrome ◽

Population Based Study ◽

Vitamin D Levels ◽

Wide Range

Background: Conflicting evidence supports a role for vitamin D in women with reproductive disorders such as polycystic ovary syndrome (PCOS) but studies on large, unselected populations have been lacking. Methods: We conducted a general population-based study from the prospective Northern Finland Birth Cohort 1966 (NFBC1966). Serum 25-hydroksyvitamin D (25(OH)D) levels were evaluated in women with self-reported PCOS (n = 280) versus non-symptomatic controls (n = 1573) at the age of 31 with wide range of endocrine and metabolic confounders. Results: The levels of 25(OH)D were similar among women with and without self-reported PCOS (50.35 vs. 48.30 nmol/L, p = 0.051). Women with self-reported PCOS presented with a higher body mass index (BMI), increased insulin resistance, and low-grade inflammation and testosterone levels compared to controls. The adjusted linear regression model showed a positive association between total 25(OH)D levels in self-reported PCOS (β = 2.46, 95% confidence interval (CI) 0.84 to 4.08, p = 0.003). The result remained after adjustment for BMI, testosterone, homeostatic model assessment of insulin resistance (HOMA-IR), and high-sensitivity C-reactive protein (hs-CRP) levels. Conclusion: In this population-based setting, PCOS was associated with higher vitamin D levels when adjusting for confounding factors, without distinct beneficial effects on metabolic derangements.

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Serum Vitamin D Levels in Fertile and Infertile Women with Polycystic Ovary Syndrome

Geburtshilfe und Frauenheilkunde ◽

10.1055/a-0828-7798 ◽

2019 ◽

Vol 79 (05) ◽

pp. 510-516 ◽

Cited By ~ 5

Author(s):

Demet Kokanalı ◽

Mujdegul Karaca ◽

Gulnur Ozakşit ◽

Burak Elmas ◽

Yaprak Engin Üstün

Keyword(s):

Insulin Resistance ◽

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Serum Vitamin ◽

Ovary Syndrome ◽

Infertile Women ◽

Serum Vitamin D ◽

Vitamin D Levels ◽

Fertile Women

Abstract Introduction In polycystic ovary syndrome, serum vitamin D levels are known to correlate with metabolic conditions such as diabetes mellitus, metabolic syndrome and cardiovascular disease. However, there are not enough studies showing such a relationship with female fertility. We aimed to compare serum vitamin D levels in fertile and infertile women with polycystic ovary syndrome to evaluate whether vitamin D may play a role in the pathogenesis of fertility problems in women with polycystic ovary syndrome. Materials and Methods 274 infertile and 111 fertile women with polycystic ovary syndrome were included in this retrospective study. Infertile and fertile groups were matched by age, body mass index and homeostasis model assessment of insulin resistance. Anthropometric, clinical and laboratory characteristics of the women were recorded. Serum 25(OH)D3 levels were used to assess serum vitamin D levels. Results No significant differences were detected between groups in terms of anthropometric, clinical and laboratory features except for serum 25(OH)D3 levels and the incidence of vitamin D deficiency. Vitamin D levels were significantly lower and vitamin D deficiency was more common in the infertile group compared to the fertile group. When the groups were stratified into obese/non-obese or insulin resistance positive/negative, infertile obese and infertile insulin resistance-positive women had the lowest serum 25(OH)D3 levels. Conclusion Serum vitamin D levels are lower in infertile women with polycystic ovary syndrome compared to fertile women. When insulin resistance or obesity was present, vitamin D levels were reduced further. Thus, in polycystic ovary syndrome, lower vitamin D levels may play a role in the pathogenesis of fertility problems.

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Assessment of Serum Vitamin D Levels in Women with Polycystic Ovary Syndrome

Journal of the Faculty of Medicine Baghdad ◽

10.32007/19jfacmedbaghdad36.v60i2.12 ◽

2018 ◽

Vol 60 (2) ◽

pp. 93-97

Author(s):

Rana A. Hamdi ◽

Zina H. Abdul-Qahar ◽

Ekhlas J. Kadhum ◽

Fatin A. Alsaeed

Keyword(s):

Vitamin D ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Free Testosterone ◽

Serum Glucose ◽

Fasting Serum ◽

Ovary Syndrome ◽

Fasting Serum Glucose ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D

Background: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women ofreproductive age with primary features of infertility, menstrual irregularity, and clinical or biochemicalevidence of hyperandrogenism (hirsutism, acne and high androgen level). Vitamin D has a role in thedevelopment of metabolic and endocrine abnormalities in PCOS mediated by insulin resistance.Objective: Measure serum 25-hydroxy vitamin D levels in women with polycystic ovary syndrome andcompare their levels with age and body mass index matched healthy controls. Also, assess thecorrelation between insulin resistance and 25-hydroxy vitamin D among women with PCOS.Subjects and Methods: Eighty eight women were involved in this study with age range (18-34 years).Subjects were divided into two groups: Group 1- forty five women with PCOS and Group 2- forty threewomen without PCOS (as controls).Serum 25-hydroxy vitamin D, insulin, free testosterone, Luteinizing hormone (LH), Follicle stimulatinghormone (FSH) were measured by enzyme linked immunosorbent assay (ELISA), while serum calciumand fasting serum glucose were measured by spectrophotometer.Results: Significant increase in mean value of fasting serum glucose, insulin, homeostatic modelassessment of insulin resistance (HOMA-IR), LH, LH/FSH ratio, and free testosterone with significantdecrease in mean value of serum FSH, 25-hydroxy vitamin D, and calcium for patients with PCOScomparing to age and body mass index match controls. Additionally, significant negative correlationswere found between serum 25-hydroxy vitamin D levels with fasting serum glucose (r= -0.484, p=0.01),fasting serum insulin (r= -0.422, p=0.04), and HOMA-IR (r= -0.542, p=0.0001) in women with PCOS.Conclusion: Vitamin D has a role in metabolic and hormonal disturbance seen in PCOS through impactof vitamin D on insulin releasing and function.

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