Second primary malignancies (SPMs) in patients with non-pulmonary well-differentiated neuroendocrine tumours (wdNETs)

2018 ◽  
Author(s):  
Anna Dafnis ◽  
Haseem Raja ◽  
Bipasha Chakrabarty ◽  
Angela Lamarca ◽  
Richard A Hubner ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Second Primary ◽  
Well Differentiated ◽  
Second Primary Malignancies

Increased risk of certain second primary malignancies in patients treated for well-differentiated thyroid cancer

2015 ◽  
Vol 21 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Tommi T. Hakala ◽  
Juhani A. Sand ◽  
Arja Jukkola ◽  
Heini S. Huhtala ◽  
Saara Metso ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Second Primary ◽  
Increased Risk ◽  
Well Differentiated ◽  
Second Primary Malignancies

scholarly journals Quadruple Multiple Primary Malignancies: Early Detection of Second Primary Malignancy by Esophagogastroduodenoscopy/Colonoscopy Is Crucial for Patients with Classic Kaposi’s Sarcoma

Diagnostics ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 218
Author(s):  
Nobuyuki Maruyama ◽  
Yuko Okubo ◽  
Masato Umikawa ◽  
Akiko Matsuzaki ◽  
Akira Hokama ◽  
...  
Keyword(s):  
Kaposi's Sarcoma ◽  
Colon Adenocarcinoma ◽  
Kaposi’S Sarcoma ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Multiple Primary Malignancies ◽  
Stomach Adenocarcinoma ◽  
Well Differentiated ◽  
Second Primary Malignancies

Currently, Kaposi’s sarcoma (KS) is treated following the recommendations of international guidelines. These guidelines recommend esophagogastroduodenoscopy/colonoscopy for detecting multicentric KS of visceral lesions. Second primary malignancies (SPMs) are also a common KS complication; however, information on their detection and treatment is unfortunately not yet indicated in these guidelines. This paper reports on an 86-year-old man who suffered from quadruple primary malignancies: skin classic KS with colon adenocarcinoma, oral squamous cell carcinoma (maxilla), and well-differentiated stomach adenocarcinoma. Gastric cancer was incidentally detected during esophagogastroduodenoscopy, which was performed to detect visceral KS. We suggest that esophagogastroduodenoscopy/colonoscopy be routinely performed during the follow-up of patients with KS. As SPMs are crucial complications in patients with KS, these malignancies should be detected as early as possible.

scholarly journals Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Miaw-Jene Liou ◽  
Ngan-Ming Tsang ◽  
Chuen Hsueh ◽  
Tzu-Chieh Chao ◽  
Jen-Der Lin
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Remission Rate ◽  
Total Mortality ◽  
Differentiated Thyroid Carcinoma ◽  
Second Primary ◽  
External Radiotherapy ◽  
Advanced Tumor ◽  
Well Differentiated ◽  
Second Primary Malignancies

Background.The aims of this study were to analyze the clinical characteristics of SPM in patients with well-differentiated thyroid cancer and to determine the long-term prognosis in patients with double malignancies.Materials and Methods.We retrospectively analyzed 2,864 patients with well-differentiated thyroid cancer and a mean age of44.0±14.4years. Of these, 200 (7.0%) were diagnosed with SPM, 115 of which were diagnosed with metachronous SPM.Results.Of 2,864 patients, 163 (5.7%) patients died of thyroid cancer and 301 (10.5%) died of any cause by the end of the follow-up period. Multivariate analysis identified age, SPM, external radiotherapy, TNM stage, and postoperative serum Tg level to be factors independently associated with decreased survival. Of 200 patients with SPM, 74 (37.0%) died. In comparison to the anachronous and synchronous groups, the metachronous SPM group had a higher mean age; more advanced tumor, node, and metastasis stage; lower remission rate; higher postoperative radioactive iodide (131I) accumulated dose; a higher proportion of patients who underwent external radiotherapy; and higher thyroid cancer and total mortality rates.Conclusions.Patients with well-differentiated thyroid carcinoma and metachronous SPM had worse prognoses compared to patients without SPM.

Incidence of Second Primary Malignancies in Patients with Neuroendocrine Tumours

2015 ◽  
Vol 102 (1-2) ◽  
pp. 26-32 ◽  
Author(s):  
Ashley K. Clift ◽  
Panagiotis Drymousis ◽  
Adil Al-Nahhas ◽  
Harpreet Wasan ◽  
John Martin ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
Second Primary ◽  
Second Primary Malignancies

scholarly journals Second Primary Malignancies in Patients with Well-differentiated/Dedifferentiated Liposarcoma

2018 ◽  
Vol 38 (6) ◽  
pp. 3535-3542 ◽  
Author(s):  
ERIC JUNG ◽  
MARCO FIORE ◽  
ALESSANDRO GRONCHI ◽  
VALERIE GRIGNOL ◽  
RAPHAEL E. POLLOCK ◽  
...  
Keyword(s):  
Dedifferentiated Liposarcoma ◽  
Second Primary ◽  
Well Differentiated ◽  
Second Primary Malignancies

Overestimated risk of second primary malignancies in ovarian cancer patients

2000 ◽  
Vol 36 (1) ◽  
pp. 100-105 ◽  
Author(s):  
K. Bergfeldt ◽  
C. Silfverswärd ◽  
S. Einhorn ◽  
P. Hall
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Second Primary ◽  
Second Primary Malignancies

scholarly journals 1169P First-line fluoropyrimidine and oxaliplatin chemotherapy in gastro-entero-pancreatic grade 3 well-differentiated neuroendocrine tumours (NET G3)

2020 ◽  
Vol 31 ◽  
pp. S776
Author(s):  
G. Lamberti ◽  
S. Pusceddu ◽  
T. Ibrahim ◽  
A. Bongiovanni ◽  
R. Berardi ◽  
...  
Keyword(s):  
Neuroendocrine Tumours ◽  
First Line ◽  
Net G3 ◽  
Well Differentiated ◽  
Grade 3

Second primary malignancies in patients treated for gastric mucosa-associated lymphoid tissue lymphoma

2017 ◽  
Vol 58 (9) ◽  
pp. 2057-2064 ◽  
Author(s):  
Aurelien Amiot ◽  
Valerie Jooste ◽  
Charlotte Gagniere ◽  
Michaël Lévy ◽  
Christiane Copie-Bergman ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Lymphoid Tissue ◽  
Second Primary ◽  
Second Primary Malignancies

scholarly journals Diagnosis and Prognosis of Neuroendocrine Tumours of the Lung by Means of High Resolution Image Analysis

1999 ◽  
Vol 18 (2) ◽  
pp. 109-119 ◽  
Author(s):  
Uta Jütting ◽  
Peter Gais ◽  
Karsten Rodenacker ◽  
Joachim Böhm ◽  
Susanne Koch ◽  
...  
Keyword(s):  
Image Analysis ◽  
High Resolution ◽  
Neuroendocrine Tumours ◽  
Malignant Potential ◽  
Low Grade ◽  
Malignant Tumours ◽  
Cox Regression Analysis ◽  
Resolution Image ◽  
High Resolution Image ◽  
Well Differentiated

Neuroendocrine tumours (NET) of the lung are divided in subtypes with different malignant potential. The first is the benign or low‐grade malignant tumours, well‐differentiated, called typical carcinoids (TC) and the second is the high‐grade malignant tumours, poorly differentiated of small (SCLC) or large cell type (LCLC). Between these tumour types lies the well‐differentiated carcinoma with a lower grade of malignancy (WDNEC). In clinical routine it is very important with regard to prognosis to distinguish patients with low malignant potential from those with higher ones. In this study 32 cases of SCLC, 13 of WDNEC and 14 of TC with a follow‐up time up to 7 years were collected. Sections 4 μm thick from paraffin embedded tissue were Feulgen stained. By means of high resolution image analysis 100 nuclei per case were randomly gathered to extract morphometric, densitometric and textural quantitative features. To investigate the ploidy status of the tumour the corrected DNA distribution was calculated. Stepwise linear discriminant analysis to differentiate the classes and Cox regression analysis for the survival time analysis were applied. Using chromatin textural and morphometric features in two two‐class discriminations, 11 of the 14 TC cases and 8 of the 13 WDNEC cases were correctly classified and 11/13 WDNEC cases and 28/32 SCLC cases, respectively. The WDNEC cases are more similar in chromatin structure to TC than to SCLC. For the survival analysis, only chromatin features were selected to differentiate patients with better and worse prognosis independent of staging and tumour type.

Second primary malignancies among women with uterine sarcoma

2012 ◽  
Vol 126 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Riitta Koivisto-Korander ◽  
Ghislaine Scélo ◽  
Gilles Ferro ◽  
Lene Mellemkjaer ◽  
Kari Hemminki ◽  
...  
Keyword(s):  
Uterine Sarcoma ◽  
Second Primary ◽  
Second Primary Malignancies
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