Adult presentation of classical Congenital Adrenal Hyperplasia with gender identity disorder

2019 ◽  
Author(s):  
Achini Wijesinghe ◽  
Peter Novodvorsky ◽  
William Bennet
Keyword(s):  
Gender Identity ◽  
Congenital Adrenal Hyperplasia ◽  
Gender Identity Disorder ◽  
Adrenal Hyperplasia ◽  
Adult Presentation

Female to male gender identity disorder in a patient with non-classical congenital adrenal hyperplasia

2014 ◽  
Author(s):  
Eva Lau ◽  
Jose Luis Castedo ◽  
Pedro Rodrigues ◽  
Zelia Figueiredo ◽  
Davide Carvalho
Keyword(s):  
Gender Identity ◽  
Congenital Adrenal Hyperplasia ◽  
Gender Identity Disorder ◽  
Male Gender ◽  
Adrenal Hyperplasia

WOMEN WITH NONCLASSIC CONGENITAL ADRENAL HYPERPLASIA HAVE GENDER, SEXUALITY, AND QUALITY-OF-LIFE FEATURES SIMILAR TO THOSE OF NONAFFECTED WOMEN

2020 ◽  
Vol 26 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Anat Segev-Becker ◽  
Roi Jacobson ◽  
Ronnie Stein ◽  
Ori Eyal ◽  
Asaf Oren ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Sexual Orientation ◽  
Gender Identity ◽  
Congenital Adrenal Hyperplasia ◽  
World Health ◽  
Study Group ◽  
Adrenal Hyperplasia ◽  
Quality Of Life Questionnaires ◽  
The Impact

Objective: Females with the severe classic forms of congenital adrenal hyperplasia reportedly have a higher frequency of atypical gender identity, nonheterosexual sexual relationships, and cross-gender role behavior. Comparable data and quality-of-life measures among those with the milder, more prevalent form, nonclassic congenital adrenal hyperplasia, are scarce. We aimed to assess health-related quality of life, gender identity, role, and sexual orientation in women with nonclassic congenital adrenal hyperplasia via a prospective, questionnaire-based, case-control study. Methods: Thirty-eight women with nonclassic congenital adrenal hyperplasia (median age 34 years; range, 18 to 44 years) and 62 age-matched female controls were recruited. Outcome measures included the Multi-Gender Identity, Sexuality, and World Health Organization (WHO) quality-of-life questionnaires. Results: Sociodemographic parameters (marital status, number of children, and educational level) were similar for both groups, as were most measures of the Multi-Gender Identity, Sexuality, and WHO quality-of-life questionnaires. However, “sometimes-feeling-as-a-man and sometimes-feeling-as-a-woman” were more frequently reported in the study group compared to the controls (7/38 [18.4%] vs. 3/62 [4.8%], respectively; P = .02). Furthermore, more nonclassic congenital adrenal hyperplasia women reported first falling in love with a woman (4/37 [10.8%] vs. 0/58 [0%]; P = .02). Conclusion: Our findings suggest possible subtle differences in gender identity and sexual orientation between adult nonclassic congenital adrenal hyperplasia females and controls. Quality of life was not impaired in individuals within the study group. The impact of exposure to mildly elevated androgen levels during childhood and adolescence on the female brain warrants more in-depth assessment in further studies. Abbreviations: CAH = congenital adrenal hyperplasia; Multi-GIQ = Multi-Gender Identity Questionnaire; NCCAH = nonclassic congenital adrenal hyperplasia; QoL = quality of life

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