The use of Thyroid Uptake scan in non-malignant thyroid disease; a multicentre audit

Objective: For radioactive Iodine-131 (131I) treatments of thyroid diseases, increased efficacy has been reported for personalized dosimetry treatments. The measurement of Iodine-131 thyroid uptake (131IU) is required in these cases. This study aims to investigate whether 99mTc thyroid uptake (99mTcU) may be used in place of 131IU for implementing personalised treatments. Methods: A retrospective study of 152 benign thyroid disease 131I treatments was carried out during 2012–2020; 117 treatments were for female patients while 35 were for male patients diagnosed with either Graves’ disease, multinodular goitre or toxic nodules. Results: A statistically significant correlation was found between 131IU and 99mTcU data, with the data more correlated for male than female patients (r = 0.71 vs 0.38, p-value < 0.001). Patient age and time difference between the two respective uptake measurements significantly influenced the uptake correlation in females but not for the male cohort, although there was no significant difference between the parameters across gender. Thyroid diagnosis and hormone levels showed a significant correlation with uptakes in both genders. Estimating 131IU based on 99mTcU was shown to be predictive for male but not in female patients (R2 = 91% vs 16%). Conclusion: Estimating 131IU based on 99mTcU is not recommended for females at our centre. Males reported good correlation, but a larger sample would be needed for validation. Advances in knowledge: The initial findings showed a significant gender difference in benign thyroid uptake parameters at our centre, highlighting the potential need for gender consideration when planning 131IU patient management and when reporting studies results.

Download Full-text

Somatostatin Receptor Expression in the Thyroid Demonstrated with 111In-Octreotide Scintigraphy

Nuklearmedizin ◽

10.1055/s-0038-1629763 ◽

1995 ◽

Vol 34 (03) ◽

pp. 100-103 ◽

Cited By ~ 10

Author(s):

U. Schrell ◽

M. Buchfelder ◽

J. Hensen ◽

J. Wendler ◽

M. Gramatzki ◽

...

Keyword(s):

Thyroid Gland ◽

Thyroid Disease ◽

Endemic Goiter ◽

Somatostatin Receptor ◽

Receptor Expression ◽

Graves Disease ◽

Tumor Localization ◽

Thyroid Autonomy ◽

Thyroid Uptake ◽

Octreotide Scintigraphy

SummaryNeuroendocrine tumors with somatostatin receptor expression may be localized by 111ln-octreotide scintigraphy. This study examines those thyroid conditions where 111 ln-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111 ln-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland. 14 patiens with 111ln thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves’ disease. Thus, 111 ln-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.

Download Full-text

Absent 99mTc-MIBI Uptake in the Thyroid Gland during Early Phase of Parathyroid Scintigraphy in Patients with Primary and Secondary Hyperparathyroidism

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2018.118 ◽

2018 ◽

Vol 6 (5) ◽

pp. 808-813 ◽

Cited By ~ 1

Author(s):

Anamarija Jovanovska ◽

Bojana Stoilovska ◽

Magdalena Mileva ◽

Daniela Miladinova ◽

Venjamin Majstorov ◽

...

Keyword(s):

Renal Failure ◽

Chronic Renal Failure ◽

Thyroid Gland ◽

Thyroid Disease ◽

Early Phase ◽

Dual Phase ◽

Parathyroid Scintigraphy ◽

Thyroid Uptake ◽

Planar Images ◽

99Mtc Mibi

BACKGROUND: Thyroid uptake of technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) during parathyroid scintigraphy can be affected by various conditions.AIM: To evaluate the frequency of absent 99mTc-MIBI uptake by the thyroid gland in the early phase of dual-phase parathyroid scintigraphy.METHODS: The early planar images of dual phase Tc99m MIBI parathyroid scintigraphy from 217 patients performed between 2014 and 2017 were retrospectively analysed. Patients were divided into two groups. The first group included 147 patients with primary hyperparathyroidism and the second group included 70 patients with chronic renal failure. Patient records, laboratory and ultrasonographic data were analysed in all patients. Descriptive statistic was used for data analysis.RESULTS: Out of all patients in the first group, 18 patients (12.24%) showed absent thyroid uptake. Thyroidectomy was performed in 44.4% of these patients, and the rest of them had some thyroid disease. Only one patient had no thyroid or another chronic disease. In the second group, 8 patients (11.42%) presented with absent thyroid uptake of MIBI. Among them, 5 patients had no history of thyroid disease and had been on hemodialysis programme, and 3 patients had hypothyroidism.CONCLUSION: Absent 99mTc-MIBI uptake in the thyroid during the early phase of parathyroid scintigraphy is most frequently related to thyroid disease. A small proportion of patients with chronic renal failure can present with absent 99mTc-MIBI uptake in the thyroid as well. The mechanism for this alteration is still unclear and needs further investigation.

Download Full-text

Estimating I-131 Thyroid Uptake from Tc-99m scintigraphy: Implication for calculated I-131 Therapy Activities in Benign Thyroid Disease

Physica Medica ◽

10.1016/j.ejmp.2019.09.223 ◽

2019 ◽

Vol 67 ◽

pp. 208

Author(s):

Amna Al Jabri ◽

Jennie Cooke ◽

Seán Cournane ◽

Marie-Louise Healy

Keyword(s):

Thyroid Disease ◽

Benign Thyroid Disease ◽

Thyroid Uptake ◽

Benign Thyroid

Download Full-text

99mTc-sestamibi thyroid uptake in euthyroid individuals and in patients with autoimmune thyroid disease

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-004-1728-1 ◽

2005 ◽

Vol 32 (6) ◽

pp. 702-707 ◽

Cited By ~ 6

Author(s):

Allan O. Santos ◽

D.E. Zantut-Wittmann ◽

R.O. Nogueira ◽

E.C.S.C. Etchebehere ◽

M.C.L. Lima ◽

...

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Autoimmune Thyroid ◽

Thyroid Uptake ◽

99Mtc Sestamibi

Download Full-text

What need is there for standardization of thyroid uptake or scintigraphy using 99mTc pertechnetate in thyroid disease diagnosis?

Sao Paulo Medical Journal ◽

10.1590/s1516-31802002000200002 ◽

2002 ◽

Vol 120 (2) ◽

pp. 36-37

Author(s):

Egberto Gaspar de Moura

Keyword(s):

Thyroid Disease ◽

Disease Diagnosis ◽

99Mtc Pertechnetate ◽

Thyroid Uptake ◽

Thyroid Disease Diagnosis

Download Full-text

Autoimmune Thyroid Disease and Keratoconus: Is There an Association?

International Journal of Endocrinology ◽

10.1155/2018/7907512 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Hussam H. Alhawari ◽

Yousef S. Khader ◽

Hussein H. Alhawari ◽

Amal F. Alomari ◽

Hiba N. Abbasi ◽

...

Keyword(s):

Thyroid Disease ◽

Autoimmune Thyroid Disease ◽

Case Reports ◽

University Hospital ◽

Thyroid Peroxidase ◽

Autoimmune Thyroid ◽

Thyroid Uptake ◽

Antithyroglobulin Antibodies ◽

And Gender ◽

Study Participants

Purpose.The association between autoimmune diseases and keratoconus (KC) has been proposed based on previous retrospective studies and case reports. The aim of our study is to investigate whether KC is associated with autoimmune thyroid disease. Methods.A comparative study was conducted on 131 adult subjects from September 2015 to May 2017 at Jordan University Hospital, Amman, Jordan. Subjects were classified into 2 groups: subjects with autoimmune thyroid disease, including Graves’ disease and Hashimoto’s thyroiditis (n=68), and a healthy group for comparison (n=63). Subjects with any other conditions known to be associated with KC were excluded. The diagnosis of KC was based on clinical and corneal topographic findings utilizing the Oculus-Pentacam machine. In addition, TSH and total T4 levels as well as thyroid peroxidase antibodies were measured in all study participants. Antithyroglobulin antibodies, thyroid stimulating immunoglobulin, thyroid ultrasound, and thyroid uptake and scan were also selectively performed in some participants.Results.This study included a total of 131 participants (101 females and 30 males), including patients and controls. In the multivariate analysis, autoimmune disease was not significantly associated with keratoconus (OR = 1.1; 95% confidence interval: 0.3, 3.8;pvalue = 0.353) after adjusting for age and gender.Conclusion.This study did not show a statistically significant association between autoimmune thyroid disease and KC.

Download Full-text