The Role of Clopidogrel and Acetylsalicylic Acid in the Prevention of Early-Phase Graft Occlusion Due to Reactive Thrombocytosis after Coronary Artery Bypass Operation

2008 ◽  
Vol 11 (3) ◽  
pp. E152-E157 ◽  
Author(s):  
Ilyas Kayacioglu ◽  
Rafet Gunay ◽  
Huseyin Saskin ◽  
Mustafa Idiz ◽  
Yavuz Sensoz ◽  
...  
2021 ◽  
Vol 10 (11) ◽  
pp. 2317
Author(s):  
Dominika Siwik ◽  
Magdalena Gajewska ◽  
Katarzyna Karoń ◽  
Kinga Pluta ◽  
Mateusz Wondołkowski ◽  
...  

Acetylsalicylic acid (ASA) is one of the most frequently used medications worldwide. Yet, the main indications for ASA are the atherosclerosis-based cardiovascular diseases, including coronary artery disease (CAD). Despite the increasing number of percutaneous procedures to treat CAD, coronary artery bypass grafting (CABG) remains the treatment of choice in patients with multivessel CAD and intermediate or high anatomical lesion complexity. Taking into account that CABG is a potent activator of inflammation, ASA is an important part in the postoperative therapy, not only due to ASA antiplatelet action, but also as an anti-inflammatory agent. Additional benefits of ASA after CABG include anticancerogenic, hypotensive, antiproliferative, anti-osteoporotic, and neuroprotective effects, which are especially important in patients after CABG, prone to hypertension, graft occlusion, atherosclerosis progression, and cognitive impairment. Here, we discuss the pleiotropic effects of ASA after CABG and provide insights into the mechanisms underlying the benefits of treatment with ASA, beyond platelet inhibition. Since some of ASA pleiotropic effects seem to increase the risk of bleeding, it could be considered a starting point to investigate whether the increase of the intensity of the treatment with ASA after CABG is beneficial for the CABG group of patients.


1997 ◽  
Vol 64 (6) ◽  
pp. 1694-1701 ◽  
Author(s):  
Willem J Flameng ◽  
Bharati Shivalkar ◽  
Bart Spiessens ◽  
Alex Maes ◽  
Johan Nuyts ◽  
...  

1991 ◽  
Vol 66 (1) ◽  
pp. 45-53 ◽  
Author(s):  
THOMAS D. BATIUK ◽  
STEPHEN B. KURTZ ◽  
JAE K. OH ◽  
THOMAS A. ORSZULAK

2004 ◽  
Vol 17 (5) ◽  
pp. 489-490 ◽  
Author(s):  
Ildiko Agoston ◽  
Rakshak Sarda ◽  
Antonio J Chamoun ◽  
Scott D Lick ◽  
Masood Ahmad

2001 ◽  
Vol 71 (2) ◽  
pp. 521-530 ◽  
Author(s):  
Thomas A Schwann ◽  
Robert H Habib ◽  
Anoar Zacharias ◽  
Gary L Parenteau ◽  
Christopher J Riordan ◽  
...  

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