scholarly journals DNA Damage Differentially Activates Regional Chromosomal Loci for Tn7 Transposition inEscherichia coli

Genetics ◽  
2008 ◽  
Vol 179 (3) ◽  
pp. 1237-1250 ◽  
Author(s):  
Qiaojuan Shi ◽  
Adam R. Parks ◽  
Benjamin D. Potter ◽  
Ilan J. Safir ◽  
Yun Luo ◽  
...  
2017 ◽  
Vol 28 (12) ◽  
pp. 1701-1711 ◽  
Author(s):  
Josh Lawrimore ◽  
Timothy M. Barry ◽  
Raymond M. Barry ◽  
Alyssa C. York ◽  
Brandon Friedman ◽  
...  

Chromatin exhibits increased mobility on DNA damage, but the biophysical basis for this behavior remains unknown. To explore the mechanisms that drive DNA damage–induced chromosome mobility, we use single-particle tracking of tagged chromosomal loci during interphase in live yeast cells together with polymer models of chromatin chains. Telomeres become mobilized from sites on the nuclear envelope and the pericentromere expands after exposure to DNA-damaging agents. The magnitude of chromatin mobility induced by a single double-strand break requires active microtubule function. These findings reveal how relaxation of external tethers to the nuclear envelope and internal chromatin–chromatin tethers, together with microtubule dynamics, can mobilize the genome in response to DNA damage.


1998 ◽  
Vol 273 (46) ◽  
pp. 30232-30238 ◽  
Author(s):  
Esther Dahan-Grobgeld ◽  
Zvi Livneh ◽  
Antonio F. Maretzek ◽  
Sylvie Polak-Charcon ◽  
Zehava Eichenbaum ◽  
...  

1992 ◽  
Vol 20 (22) ◽  
pp. 6023-6032 ◽  
Author(s):  
Michael L. Wood ◽  
Asuncion Esteve ◽  
Marshall L. Morningstar ◽  
Geoffrey M. Kuziemko ◽  
John M. Essigmann

2004 ◽  
Vol 60 (a1) ◽  
pp. s158-s158
Author(s):  
A. Teplyakov ◽  
G. Obmolova ◽  
P. Khil ◽  
J. E. Ladner ◽  
R. D. Camerini-Otero ◽  
...  

2004 ◽  
Vol 171 (4S) ◽  
pp. 416-416
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Sijo J. Parekattil ◽  
...  

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