scholarly journals Dosage Mutator Genes inSaccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase

Genetics ◽  
2016 ◽  
Vol 204 (3) ◽  
pp. 975-986 ◽  
Author(s):  
J. Sidney Ang ◽  
Supipi Duffy ◽  
Romulo Segovia ◽  
Peter C. Stirling ◽  
Philip Hieter
Keyword(s):  
Mode Of Action ◽  
Dna Helicase ◽  
Mutator Genes

scholarly journals The control of mutational instability by a new mutator gene ofDrosophila melanogaster

1975 ◽  
Vol 25 (2) ◽  
pp. 163-177 ◽  
Author(s):  
R. C. Woodruff
Keyword(s):  
Drosophila Melanogaster ◽  
Mode Of Action ◽  
Genetic Characterization ◽  
Dominant Gene ◽  
Mutator Gene ◽  
Reversion Frequency ◽  
Males And Females ◽  
Mutator Genes

SUMMARYThe isolation and genetic characterization of a new mutator gene,Mutator-forked3N(Mu-f3N), ofDrosophila melanogasterare described. This mutator gene is unique in that it seems to increase specifically the reversion frequency of the unstable mutantforked3N(f3N, 1–56.7), since the frequency of spontaneous sex-linked recessive lethals in males and females and the frequency of reverse mutations at eight additional X-linked alleles were unaffected byMu-f3N. The mutator is a dominant gene that has been mapped to the region betweenf3N(1–56.7) andBeadex-2 (Bx2, 1–59.4) in theXchromosome, and it seems to function only in the ‘ cis’ configuration. The mode of action ofMu-f3Nis compared with that of other mutator genes.

Effects of 5-5'-Diphenyl-2-thiohydantoin (DPTH) and Thyroxine on the Ultrastructure and Chemical Composition of Rat Liver

1971 ◽  
Vol 29 ◽  
pp. 570-571
Author(s):  
E. A. Elfont ◽  
R. B. Tobin ◽  
D. G. Colton ◽  
M. A. Mehlman
Keyword(s):  
Chemical Composition ◽  
Rat Liver ◽  
Future Study ◽  
Mode Of Action ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Effective Inhibitor ◽  
Biochemical Effects ◽  
Glycerophosphate Dehydrogenase ◽  
Stimulation Of

Summary5,-5'-diphenyl-2-thiohydantoin (DPTH) is an effective inhibitor of thyroxine (T4) stimulation of α-glycerophosphate dehydrogenase in rat liver mitochondria. Because this finding indicated a possible tool for future study of the mode of action of thyroxine, the ultrastructural and biochemical effects of DPTH and/or thyroxine on rat liver mere investigated.Rats were fed either standard or DPTH (0.06%) diet for 30 days before T4 (250 ug/kg/day) was injected. Injection of T4 occurred daily for 10 days prior to sacrifice. After removal of the liver and kidneys, part of the tissue was frozen at -50°C for later biocheailcal analyses, while the rest was prefixed in buffered 3.5X glutaraldehyde (390 mOs) and post-fixed in buffered 1Z OsO4 (376 mOs). Tissues were embedded in Araldlte 502 and the sections examined in a Zeiss EM 9S.Hepatocytes from hyperthyroid rats (Fig. 2) demonstrated enlarged and more numerous mitochondria than those of controls (Fig. 1). Glycogen was almost totally absent from the cytoplasm of the T4-treated rats.

Mode of action of 6-oxophenolic triterpenoids against Bacillus subtilis

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
L Moujir ◽  
L de León ◽  
IL Bazzocchi
Keyword(s):  
Bacillus Subtilis ◽  
Mode Of Action
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