The control of mutational instability by a new mutator gene ofDrosophila melanogaster
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SUMMARYThe isolation and genetic characterization of a new mutator gene,Mutator-forked3N(Mu-f3N), ofDrosophila melanogasterare described. This mutator gene is unique in that it seems to increase specifically the reversion frequency of the unstable mutantforked3N(f3N, 1–56.7), since the frequency of spontaneous sex-linked recessive lethals in males and females and the frequency of reverse mutations at eight additional X-linked alleles were unaffected byMu-f3N. The mutator is a dominant gene that has been mapped to the region betweenf3N(1–56.7) andBeadex-2 (Bx2, 1–59.4) in theXchromosome, and it seems to function only in the ‘ cis’ configuration. The mode of action ofMu-f3Nis compared with that of other mutator genes.
2000 ◽
Vol 263
(1)
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pp. 137-143
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1980 ◽
Vol 180
(2)
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pp. 419-424
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2011 ◽
Vol 47
(5)
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pp. 521-532
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