Morphometric Study of Gender Differences with Regard to Age-Related Changes in the C57BL/6 Mouse Kidney

Background: Changes in the size of the kidney are evident in humans, as age progresses. Objective: To see the age-related changes in the morphological dimensions of the kidney in a sample of the Bangladeshi population. Methods: This crosssectional study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2008 to June 2009, based on a collection of 140 postmortem human kidneys collected from 70 unclaimed dead bodies from the morgue of the same institution. All the samples of kidney were divided into three age groups, including A (10-19 years), B (20-39 years) and C (40-59 years). The length, breadth and thickness of all the kidneys were measured by using a slide calipers and recorded. Data were expressed as mean±SD. For statistical analysis, independent sample t test and one way ANOVA was used. Results: The length of the right and left kidneys found were 8.72±0.25 cm and 9.28±0.12 cm; 9.73±0.35 cm and 10.31±0.41 cm; 9.68±0.21 cm and 10.24±0.06 cm in group A, B and C respectively. The breadth of the right and left kidneys found were 4.32±0.09 cm and 4.22±0.11 cm; 4.74±0.29 cm and 4.55±0.28 cm; 4.61±0.21 cm and 4.44±0.21 cm in group A, B and C respectively. The thickness of the right and left kidneys found were 2.84±0.10 cm and 2.64±0.05 cm; 3.31±0.16 cm and 3.11±0.10 cm; 3.17±0.07 cm and 3.11±0.10 cm in group A, B and C respectively. The mean length of the left kidneys was found significantly greater than that of the right , whereas the mean breadth and the thickness of the right kidneys were found greater than that of the left kidney in all age groups. Moreover, age related changes were significant in all dimensions (length, breadth and thickness) of the kidney when compared between group A & B and A & C. Conclusion: This study results concluded that the length of the left kidney was greater than that of the right, but the breadth and the thickness of the right kidney were greater than that of the left one in all age groups. In addition, age related changes in all dimensions (i.e. length, breadth and thickness) of the kidneys were evident in middle age versus young adult and older adult versus young adult. J Bangladesh Soc Physiol. 2020, December; 15(2): 61-67

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Gender Differences in Age-Related Changes in Cardiac Autonomic Nervous Function

Journal of Aging Research ◽

10.1155/2012/679345 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 56

Author(s):

Shailaja Moodithaya ◽

Sandhya T. Avadhany

Keyword(s):

Gender Differences ◽

Nervous Activity ◽

Age Groups ◽

Low Frequency ◽

Frequency Domain Analysis ◽

Total Power ◽

Adult Age ◽

Autonomic Nervous ◽

Age Related ◽

Age Related Changes

Ageing is associated with changes in cardiac autonomic control as measured by Heart Rate Variability (HRV). Not many studies have explored the influence of gender on age-related changes in cardiac autonomic regulation. This study evaluated the gender differences in age-associated changes in cardiac autonomic nervous activity by assessing HRV using frequency domain analysis of short-term stationary R-R intervals. HRV was studied in healthy males and females ranging in age from 6 to 55 years. Total power and absolute power in High-Frequency (HF) and Low-Frequency (LF) components as well as HF in normalized unit declined significantly with ageing. The HF/LF ratio was significantly higher in the adolescent and adult females compared to male of these age groups. This study suggests that gender differences exist in age-related changes in HRV. The finding that gender differences are limited to adolescent and adult age groups may indicate a role for female sex hormones in cardiac autonomic modulation.

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