scholarly journals Placenta accreta spectrum disorders in pregnancies following in vitrofertilization

2021 ◽  
Vol 10 (3) ◽  
pp. 70-72
Author(s):  
Sergei Slavov

Placenta previa and related pregnancy complications are more common in In vitro fertilization pregnancies compared with spontaneous ones. There is evidence that PAS disorders are more common in pregnancies after IVF. Factors leading to a higher incidence of this pathology in IVF pregnancies have not been fully studied. Possible causes are the advanced age of women undergoing IVF, factors related to infertility itself, causes from the biological part of the In vitro procedure or controlled ovarian stimulation. The study of these factors is crucial for clinical practice as it would improve the outcome of IVF pregnancies.

Author(s):  
Anna M. Modest ◽  
Thomas L. Toth ◽  
Katherine M. Johnson ◽  
Scott A. Shainker

Objective The incidence of placenta accreta spectrum (PAS) has been increasing in the United States. In addition, there has also been an increase in the utilization of in vitro fertilization (IVF). The IVF pregnancies confer an increased risk of adverse obstetric and neonatal outcomes, but there is limited data on whether IVF is associated with PAS. The aim of this study is to assess the association between IVF and the risk of PAS. Study Design This was a retrospective cohort study of deliveries from January 1, 2013 to August 1, 2018 at a tertiary hospital in the Massachusetts. IVF pregnancies were compared with non-IVF pregnancies, and PAS diagnosis was confirmed by histopathology reports. Hospital administrative data and medical record review were used, and supplemented with data from birth certificates from the Massachusetts Department of Public Health. Results We identified 28,344 pregnancies that met inclusion criteria, of which 1,418 (5.0%) were IVF pregnancies. The overall incidence of PAS was 0.4% (2.2% in the IVF group and 0.3% in the non-IVF group). Women who underwent IVF had 5.5 times the risk of PAS (95% confidence interval [CI]: 3.4–8.7) compared with women in the non-IVF group, adjusted for maternal age, nulliparity, and year of delivery (Table 5). Compared with women in the non-IVF group, the IVF group had fewer prior cesarean deliveries (22.6 vs. 64.2%) and a lower prevalence of placenta previa (19.4 vs. 44.4%). Conclusion Women with an IVF pregnancy carry an increased risk of PAS compared with non-IVF. Among women who underwent IVF, there was a lower prevalence of prior cesarean deliveries and placenta previa. Future work is needed to identify the mechanism of association for this increased risk as well as a reliable tool for antenatal detection in this cohort of women. Key Points


2021 ◽  
Vol 41 (3) ◽  
pp. 126-127
Author(s):  
B. Salmanian ◽  
K.A Fox ◽  
S.E. Arian ◽  
H. Erfani ◽  
S.L. Clark ◽  
...  

2020 ◽  
Vol 222 (1) ◽  
pp. S668-S669
Author(s):  
Bahram Salmanian ◽  
Hadi Erfani ◽  
Sara Arian ◽  
Jimmy Espinoza ◽  
Ahmed A. Nassr ◽  
...  

2020 ◽  
Vol 223 (4) ◽  
pp. 568.e1-568.e5 ◽  
Author(s):  
Bahram Salmanian ◽  
Karin A. Fox ◽  
Sara E. Arian ◽  
Hadi Erfani ◽  
Steven L. Clark ◽  
...  

2019 ◽  
Vol 69 (12) ◽  
pp. 3611-3615
Author(s):  
Claudia Mehedintu ◽  
Elvira Bratila ◽  
Lacramioara Aurelia Brinduse ◽  
Monica Mihaela Cirstoiu ◽  
Costin Berceanu ◽  
...  

The main objective of the this study is to compare the effectiveness of ovarian stimulation with recombinant gonadotrophins (FSHr) versus urinary gonadotrophins (hMG) within the number of oocytes obtained and the number of embryos in the two patient groups, according to age groups and associated pathologies. The study design was retrospective, monocentric. All patients (71) who have addressed the In Vitro Fertilization Clinic of the Prof. Dr. Panait Sirbu Clinical Obstetrics and Gynecology Hospital during 01.01.2010 and 31.12.2010 were included in this research. The total number of oocytes (8.5�3.9 vs 5.7�3.9, p=0.045), the number of fertilized oocytes (7.5�3.6 versus 3.6�2.8 p=0.004) and the number of embryos (6.6�3.5 versus 3.7�2.6, p=0.013) were higher in women under 35 years of age treated with recombinant FSHr compared to women treated with urinary gonadotrophins hMG. Ovarian stimulation with recombinant gonadotrophins provides a greater number of oocytes and a greater number of embryos in all patients, regardless of age and associated pathology. There are many variables that can influence the success rate, but the first variable that can be controlled is the choice of FSHr in daily clinical practice.


2022 ◽  
Vol 226 (1) ◽  
pp. S518
Author(s):  
Anna M. Modest ◽  
Brett D. Einerson ◽  
Albaro Jose Nieto ◽  
Vineet Shrivastava ◽  
Alireza A. Shamshirsaz ◽  
...  

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