scholarly journals Antibiotic Prophylaxis for Urinary Tract Infection–Related Renal Scarring: A Systematic Review

PEDIATRICS ◽  
2017 ◽  
Vol 139 (5) ◽  
pp. e20163145 ◽  
Author(s):  
Ian K. Hewitt ◽  
Marco Pennesi ◽  
William Morello ◽  
Luca Ronfani ◽  
Giovanni Montini
Keyword(s):  
Systematic Review ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Prophylaxis ◽  
Renal Scarring

Risk of Renal Scarring in Children With a First Urinary Tract Infection: A Systematic Review

PEDIATRICS ◽  
2010 ◽  
Vol 126 (6) ◽  
pp. 1084-1091 ◽  
Author(s):  
N. Shaikh ◽  
A. L. Ewing ◽  
S. Bhatnagar ◽  
A. Hoberman
Keyword(s):  
Systematic Review ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Renal Scarring

Antibiotic prophylaxis for children at risk of developing urinary tract infection: a systematic review

2009 ◽  
Vol 98 (11) ◽  
pp. 1781-1786 ◽  
Author(s):  
Rintaro Mori ◽  
Anita Fitzgerald ◽  
Craig Williams ◽  
Kjell Tullus ◽  
Kate Verrier-Jones ◽  
...  
Keyword(s):  
Systematic Review ◽  
At Risk ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Prophylaxis ◽  
Children At Risk

Antimicrobial Prophylaxis for Children With Vesicoureteral Reflux

2021 ◽  
pp. 257-262
Author(s):  
Philipp Dahm ◽  
Jane M. Lewis
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Prophylaxis ◽  
Vesicoureteral Reflux ◽  
Antimicrobial Prophylaxis ◽  
Renal Scarring ◽  
Symptomatic Urinary Tract Infection ◽  
Randomized Intervention ◽  
Tract Infections

This chapter summarizes the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial, a landmark trial that randomized children with vesicoureteral reflux diagnosed after a first or second febrile or symptomatic urinary tract infection to receive trimethoprim–sulfamethoxazole (TMP-SMX) prophylaxis versus placebo. It found that antibiotic prophylaxis reduced the incidence of recurrent febrile or symptomatic urinary tract infection but had little effect on renal scarring. Recurrent febrile or symptomatic urinary tract infections resistant pathogens were increased. This study provides the underpinning for guidelines that advocate for low-dose antibiotic prophylaxis for the first year of life; however, this remains an area of considerable controversy.

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