AVITAMINOSIS E IN CYSTIC FIBROSIS OF THE PANCREAS

PEDIATRICS ◽  
1958 ◽  
Vol 22 (3) ◽  
pp. 494-506
Author(s):  
William A. Blanc ◽  
Joseph D. Reid ◽  
Dorothy H. Andersen
Keyword(s):  
Cystic Fibrosis ◽  
Smooth Muscle ◽  
Vitamin E ◽  
Gastrointestinal Tract ◽  
Striated Muscle ◽  
Vitamin E Deficiency ◽  
Severe Vitamin ◽  
Second Year ◽  
Avitaminosis E ◽  
Ceroid Pigment

Ceroid-pigment is present in the smooth muscle fibers of the gastrointestinal tract of patients with cystic fibrosis of the pancreas. It is first seen during the second year of life. It is found in all patients of 5 years of age and older, and the amount increases with age. It has not been found in other pediatric conditions with the exception of biliary atresia and cirrhosis of the liver. Extensive ceroid deposit probably represents an expression of prolonged and severe vitamin-E deficiency, related to protracted malabsorption of fat-soluble tocopherols. Alterations of striated muscle appear to be rare and minimal in cystic fibrosis of the pancreas.

Severe Vitamin E deficiency exacerbates acute hyperoxic lung injury associated with increased oxidative stress and inflammation

2008 ◽  
Vol 42 (6) ◽  
pp. 602-612 ◽  
Author(s):  
Shigeo Yamaoka ◽  
Han-Suk Kim ◽  
Tohru Ogihara ◽  
Shinya Oue ◽  
Kimitaka Takitani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Lung Injury ◽  
Vitamin E Deficiency ◽  
Severe Vitamin ◽  
Hyperoxic Lung Injury

Severe Hemolytic Anemia Associated With Vitamin E Deficiency in Infants With Cystic Fibrosis

1994 ◽  
Vol 33 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Benjamin S. Wilfond ◽  
Philip M. Farrell ◽  
Anita Laxova ◽  
Elaine Mischler
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Hemolytic Anemia ◽  
Vitamin E Deficiency

Application of a new test for vitamin E deficiency to cystic fibrosis

1987 ◽  
Vol 146 (5) ◽  
pp. 512-514 ◽  
Author(s):  
H. A. Cynamon ◽  
J. N. Isenberg
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Vitamin E Deficiency

Morphometry of age pigment (lipofuscin) and of ceroid pigment deposits associated with vitamin E deficiency

2002 ◽  
Vol 34 (3) ◽  
pp. 263-268 ◽  
Author(s):  
Patrizia Fattoretti ◽  
Carlo Bertoni-Freddari ◽  
Tiziana Casoli ◽  
Giuseppina Di Stefano ◽  
Moreno Solazzi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Vitamin E Deficiency ◽  
Ceroid Pigment

Gastrointestinal blood flow in the opossum with special reference to the esophagus

1990 ◽  
Vol 68 (9) ◽  
pp. 1221-1225 ◽  
Author(s):  
Folkert G. Zijlstra ◽  
Taimi T. Hynna-Liepert ◽  
P. K. Dinda ◽  
Ivan T. Beck ◽  
William G. Paterson
Keyword(s):  
Animal Model ◽  
Blood Flow ◽  
Smooth Muscle ◽  
Gastrointestinal Tract ◽  
Lower Esophageal Sphincter ◽  
Striated Muscle ◽  
Muscularis Propria ◽  
Distal Esophagus ◽  
Muscle Fibres ◽  
Esophageal Sphincter

The opossum esophagus, like that of the human, is composed of striated muscle fibres proximally and smooth muscle fibres distally. Because of this similarity the opossum has been used extensively as an animal model for esophageal studies, but to date no data on esophageal blood flow have been reported in this species. The purpose of this study was to establish the basal blood flow characteristics of different regions of the opossum gastrointestinal tract with particular reference to the esophagus. Intracardiac injection of 15-μm microspheres was used to provide an estimate of blood flow (mL∙min−1∙g−1 dry tissue) to the whole wall, the combined layer of mucosa plus submucosa, and the muscularis propria. Basal blood flow in the whole tissue and mucosa–submucosa was significantly higher in the lower esophageal sphincter than in the proximal or distal esophagus. The muscularis propria blood flow displayed an aborally increasing gradient with flow to proximal esophagus (striated muscle) < distal esophagus (smooth muscle) < lower esophageal sphincter. Regional differences in blood flow to other regions of the gastrointestinal tract were similar to that described in other species. In addition, no changes in basal blood flow occurred despite repeated microsphere injections, suggesting that this species provides a good animal model for the study of gastrointestinal blood flow.Key words: microspheres, blood flow, esophagus, stomach, intestine.

scholarly journals Symptomatic vitamin E deficiency in cystic fibrosis.

1985 ◽  
Vol 60 (2) ◽  
pp. 162-164 ◽  
Author(s):  
A M Bye ◽  
D P Muller ◽  
J Wilson ◽  
V M Wright ◽  
M B Mearns
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Vitamin E Deficiency

Visual and somatosensory evoked potentials in vitamin E deficiency with cystic fibrosis

1988 ◽  
Vol 71 (4) ◽  
pp. 266-272 ◽  
Author(s):  
Peter W. Kaplan ◽  
Kapil Rawal ◽  
Charles W. Erwin ◽  
Bernard J. D'Souza ◽  
Alexander Spock
Keyword(s):  
Cystic Fibrosis ◽  
Vitamin E ◽  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Vitamin E Deficiency

Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency

1987 ◽  
Vol 259 (1) ◽  
pp. 224-225 ◽  
Author(s):  
K.U. Ingold ◽  
A.C. Webb ◽  
Donna Witter ◽  
G.W. Burton ◽  
T.A. Metcalfe ◽  
...  
Keyword(s):  
Vitamin E ◽  
Human Plasma ◽  
Vitamin E Deficiency ◽  
Severe Vitamin ◽  
Chain Breaking
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