The Enhancement of Iron Absorption in Rats by D-Sorbitol

PEDIATRICS ◽  
1958 ◽  
Vol 22 (4) ◽  
pp. 705-705
Keyword(s):  
Amino Acids ◽  
Vitamin B12 ◽  
Intestinal Mucosa ◽  
Iron Absorption ◽  
Significant Enhancement ◽  
Clinical Therapy ◽  
Tartaric Acids

Recently investigations have shown that the carbohydrate, D-Sorbitol, enhances the absorption of vitamin B12. Certain amino acids and ascorbic, citric and tartaric acids tend to enhance iron absorption. In view of these findings, the authors undertook to determine the effect of D-sorbitol on iron absorption in the rat. It was found that D-sorbitol causes significant enhancement of the absorption of iron in iron-depleted as well as in normal rats. It was also shown that the amount of iron absorbed increased in proportion to the amount of D-sorbitol administered with the iron. These experiments suggest that the absorption of iron may not be controlled exclusively by the amount of apoferritin in the intestinal mucosa. Possible beneficial or deleterious consequences of the application of these findings to clinical therapy remain to be determined.

scholarly journals Cloning of the cDNA encoding mast cell tryptase of Mongolian gerbil, Meriones unguiculatus, and its preferential expression in the intestinal mucosa

1995 ◽  
Vol 309 (3) ◽  
pp. 921-926 ◽  
Author(s):  
Y Murakumo ◽  
H Ide ◽  
H Itoh ◽  
M Tomita ◽  
T Kobayashi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Mast Cell ◽  
Small Intestine ◽  
Mast Cells ◽  
Intestinal Mucosa ◽  
Mongolian Gerbil ◽  
Meriones Unguiculatus ◽  
Amino Acid Sequences ◽  
Mast Cell Tryptase ◽  
Mucosal Mast Cells

By using the combination of reverse-transcription PCR and rapid amplification of cDNA ends methods, a cDNA encoding mast cell tryptase was successfully cloned from the small intestine of Mongolian gerbil, Meriones unguiculatus, infected with Nippostrongylus brasiliensis. The cDNA was 1219 bp long including 810 bp of an open reading frame. Based on the deduced amino acid sequences of known mast cell tryptases of other species, the gerbil mast cell tryptase (gMCT) was highly similar to mouse mast cell protease (mMCP)-7, and seems to be translated as a prepro-enzyme with 25 amino acids of signal and activation peptides and 245 amino acids of mature enzyme. The gMCT mRNA was preferentially transcribed in the intestinal mucosa and to a far lesser extent in the connective tissue such as skin and tongue. Moreover, kinetic study after infection revealed that the amount of gMCT mRNA in the small intestine correlated well with the degree of intestinal mastocytosis. Throughout the course of infection, enzyme-histochemically detectable tryptase activity was limited to mucosal mast cells. Since mucosal mast cells of other rodents, including mice and rats, do not express tryptases, this is the first report of rodent mast cell tryptase expressed in the intestinal mucosa.

Importance of Anemia and Transferrin Levels in the Regulation of Intestinal Iron Absorption in Hypotransferrinemic Mice

Blood ◽  
1999 ◽  
Vol 94 (9) ◽  
pp. 3185-3192 ◽  
Author(s):  
K.B. Raja ◽  
D.J. Pountney ◽  
R.J. Simpson ◽  
T.J. Peters
Keyword(s):  
Mutant Strain ◽  
Intestinal Mucosa ◽  
Iron Uptake ◽  
Iron Absorption ◽  
Total Iron ◽  
Hepatic Iron ◽  
Short Term ◽  
Liver Iron ◽  
Intestinal Iron Absorption ◽  
Per Se

The hypotransferrinemic mouse (trf hpx) is a mutant strain exhibiting transferrin deficiency, marked anemia, hyperabsorption of iron, and elevated hepatic iron stores. We set out to investigate the relative roles of anemia and of transferrin in the malregulation of intestinal iron absorption in these animals. Transfusion of erythrocytes obtained from littermate controls increased hemoglobin levels and reduced reticulocyte counts in recipient animals. Although mucosal to carcass 59Fe transfer was reduced, total duodenal iron uptake was not significantly affected. Iron absorption in homozygotes, in contrast to littermate controls, was not reduced by hyperoxia. Mouse transferrin injections, in the short term, increased delivery of iron to the marrow and raised hemoglobin levels. Although mucosal transfer and total iron uptake were reduced at the higher transferrin doses, total uptake was still higher than in controls. Daily injections of mouse/human transferrin for 3 weeks from weaning, normalized hemoglobin values, and markedly reduced liver iron and intestinal iron absorption values in trf hpxanimals. When such daily-injected mice were left for a week to allow transferrin clearance, iron absorption values were significantly enhanced; hemoglobin or hepatic iron levels were, however, not significantly altered. These data indicate that hyperabsorption of iron in trf hpx mice is not solely because of the anemia; transferrin levels per se do affect iron absorption, possibly via a direct effect on the intestinal mucosa.

scholarly journals Supplementation with Vitamin B12 and Amino Acids of Chick Diets Containing Soybean or Cottonseed Meal

1952 ◽  
Vol 31 (1) ◽  
pp. 110-114 ◽  
Author(s):  
L.J. Machlin ◽  
C.A. Denton ◽  
H.R. Bird
Keyword(s):  
Amino Acids ◽  
Vitamin B12 ◽  
Cottonseed Meal

Non-ferritin Iron Compound in Rat Small Intestinal Mucosa during Iron Absorption

Nature ◽  
1971 ◽  
Vol 229 (5284) ◽  
pp. 409-410 ◽  
Author(s):  
M. WORWOOD ◽  
A. EDWARDS ◽  
A. JACOBS
Keyword(s):  
Intestinal Mucosa ◽  
Iron Absorption ◽  
Iron Compound ◽  
Small Intestinal Mucosa ◽  
Ferritin Iron ◽  
Small Intestinal
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