Thoughts on Vitamin E

PEDIATRICS ◽  
1980 ◽  
Vol 66 (2) ◽  
pp. 330-331
Author(s):  
Sinasi Ozoylu
Keyword(s):  
Vitamin E ◽  
Glutathione Synthetase ◽  
Vitamin E Deficiency ◽  
Synthetase Deficiency ◽  
Glutathione Synthetase Deficiency ◽  
Erythrocyte Survival ◽  
High Doses

I would like to add my short comments to the concise commentary of Phelps1 on vitamin E. In addition to the mentioned several conditions related to vitamin E metabolism, probable vitamin E deficiency in the pathogenesis of thrombocytosis in Caffey's disease2 should be remembered by the pediatricians. We have seen such a case recently.3 Improvement of erythrocyte survival in chronic hemolyzing G-6 PD and glutathione synthetase deficiency with high doses of vitamin E seems to be promising approach in the treatment of these patients.4

Protection of Granulocytes by Vitamin E in Glutathione Synthetase Deficiency

1979 ◽  
Vol 301 (17) ◽  
pp. 901-905 ◽  
Author(s):  
Laurence A. Boxer ◽  
Janet M. Oliver ◽  
Stephen P. Spielberg ◽  
John M. Allen ◽  
Joseph D. Schulman
Keyword(s):  
Vitamin E ◽  
Glutathione Synthetase ◽  
Synthetase Deficiency ◽  
Glutathione Synthetase Deficiency

scholarly journals Hemolytic anemia, recurrent metabolic acidosis, and incomplete albinism associated with glutathione synthetase deficiency

Blood ◽  
1983 ◽  
Vol 62 (4) ◽  
pp. 754-757 ◽  
Author(s):  
JT Prchal ◽  
WM Crist ◽  
M Roper ◽  
VP Wellner
Keyword(s):  
Metabolic Acidosis ◽  
Hemolytic Anemia ◽  
Male Infant ◽  
Glutathione Synthetase ◽  
Synthetase Deficiency ◽  
Glutathione Synthetase Deficiency ◽  
Febrile Episodes ◽  
Relationship Of ◽  
The Relationship ◽  
Generalized Type

Abstract The clinical and laboratory features of a 3-mo-old black male infant with glutathione (GSH) synthetase deficiency of the generalized type was evaluated. Partial albinism, brisk hemolytic anemia, recurrent febrile episodes, and mental retardation were noted. Also, severe recurrent metabolic acidosis and marked oxoprolinemia and oxoprolinuria were found in the proband but not in his first-degree relatives. The relationship of these disease manifestations to the underlying metabolic defect is discussed.

Glutathione Synthetase Deficiency

2009 ◽  
pp. 726-727
Author(s):  
David J. Timson ◽  
Richard J. Reece ◽  
James B. Thoden ◽  
Hazel M. Holden ◽  
Andrea L. Utz ◽  
...  
Keyword(s):  
Glutathione Synthetase ◽  
Synthetase Deficiency ◽  
Glutathione Synthetase Deficiency
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