Chronic Granulomatous Disease and Pneumocystis carinii Pneumonia

PEDIATRICS ◽  
1982 ◽  
Vol 69 (1) ◽  
pp. 133-134
Author(s):  
Allen D. Adinoff ◽  
Richard B. Johnston ◽  
Jale Dolen ◽  
Mary Ann South
Keyword(s):  
Chronic Granulomatous Disease ◽  
Molecular Oxygen ◽  
Pneumocystis Carinii Pneumonia ◽  
Pneumocystis Carinii ◽  
Enteric Bacteria ◽  
High Energy ◽  
Granulomatous Disease ◽  
Energy Metabolites

Chronic granulomatous disease (CGD) is a syndrome characterized by recurrent purulent infections of the skin, lungs, and reticuloendothelial organs. The underlying defect is an inability of phagocytes to convert molecular oxygen into high-energy metabolites that contribute to microbial death. Infections are primarily due to staphylococci, enteric bacteria, fungi, and occasionally mycobacteria.1 An 11-year-old girl with CGD was reported to have pneumonia due to P carinii.2 We have found a second case of CGD with pneumonia due to P carinii.

Refractory Pneumocystis carinii Infection in Chronic Granulomatous Disease: Successful Treatment with Granulocytes

PEDIATRICS ◽  
1979 ◽  
Vol 64 (6) ◽  
pp. 935-938
Author(s):  
F. Karup Pedersen ◽  
K. Staehr Johansen ◽  
Joergen Rosenkvist ◽  
lnge Tygstrup ◽  
Niels H. Valerius
Keyword(s):  
Chronic Granulomatous Disease ◽  
Humoral Immunity ◽  
Successful Treatment ◽  
Pneumocystis Carinii Pneumonia ◽  
Pneumocystis Carinii ◽  
Granulomatous Disease ◽  
Severe Infections ◽  
Pneumocystis Carinii Infection ◽  
Cellular And Humoral Immunity

Pneumocystis carinii pneumonia developed in an 11-year-old girl with chronic granulomatous disease who had normal cellular and humoral immunity. The patient remained febrile during treatment with sulfame-thoxazole-trimethoprim and pentamidine but became afebrile when treated with a series of 12 granulocyte transfusions combined with sulfamethoxazole-trimethoprim. In addition to documenting P carinii infection in chronic granulomatous disease our findings suggest that granulocyte transfusions may be of value in the treatment of severe infections in chronic granubomatous disease.

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