Letters to the Editor

McWilliams and Dunn report a case of aplastic anemia in Down's syndrome similar to our recently reported case. We can expect a flurry of other such case reports. However, since the association of aplastic anemia and Down's syndrome is still unusual, it will be interesting to document difference in predisposing factors and response to various forms of therapy.

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Aplastic Anemia and Down's Syndrome

PEDIATRICS ◽

10.1542/peds.69.4.501b ◽

1982 ◽

Vol 69 (4) ◽

pp. 501-502

Author(s):

Nancy B. McWilliams ◽

Nancy L. Dunn

Keyword(s):

Case Report ◽

Aplastic Anemia ◽

Case Reports ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Endocardial Cushion ◽

Black Girl ◽

First Case ◽

Endocardial Cushion Defect

The first case report of aplastic anemia in Down's syndrome (Weinblatt ME, Higgins G, Ortega JA: Aplastic anemia in Down's syndrome. Pediatrics 67:896, 1981) may stir up a flurry of other such case reports. We are studying a 27-month-old black girl with a 47,XX + 21 karyotype who had been doing well following repair of an endocardial cushion defect at age 10 months, until she was seen with petechiae and purpura at age 19 months.

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A Rare Double Aneuploidy Case (Down–Klinefelter)

Journal of Pediatric Genetics ◽

10.1055/s-0037-1604098 ◽

2017 ◽

Vol 06 (04) ◽

pp. 241-243 ◽

Cited By ~ 3

Author(s):

Atil Bisgin ◽

Sevcan Bozdogan

Keyword(s):

Septal Defect ◽

Case Reports ◽

Ductus Arteriosus ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Klinefelter’S Syndrome ◽

Klinefelter's Syndrome ◽

A Current ◽

Patent Ductus ◽

Double Aneuploidy

AbstractDown's syndrome has its own dysmorphic findings and is accompanied by mental retardation and hypotonia. Klinefelter's syndrome is a syndrome caused by a numerical abnormality that affects male physical and cognitive development. This case reports a unique finding of 48,XXY, + 21 and a current literature review. A 4-month-old male patient presented with typical clinical features of Down's syndrome with hypothyroidism, atrial septal defect, ventricular septal defect, and patent ductus arteriosus without any phenotypic signs of Klinefelter's syndrome.

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Aplastic anemia in Down's syndrome

American Journal of Hematology ◽

10.1002/ajh.10352 ◽

2003 ◽

Vol 73 (3) ◽

pp. 213-213 ◽

Cited By ~ 6

Author(s):

Keechilat Pavithran ◽

Navamony Laila Raji

Keyword(s):

Aplastic Anemia ◽

Down's Syndrome ◽

Down’S Syndrome

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Transient aplastic anemia in Down’s syndrome – A rare association

European Journal of Medical Genetics ◽

10.1016/j.ejmg.2011.02.005 ◽

2011 ◽

Vol 54 (3) ◽

pp. 341-342 ◽

Cited By ~ 2

Author(s):

Geeta Gathwala ◽

Poonam Dalal ◽

Jagjit Singh Dalal ◽

Ojasvini Choudhry

Keyword(s):

Aplastic Anemia ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Rare Association

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Atlantoaxial dislocation due to os odontoideum in patients with Down’s syndrome: literature review and case reports

Child s Nervous System ◽

10.1007/s00381-019-04401-y ◽

2019 ◽

Vol 36 (1) ◽

pp. 19-26 ◽

Cited By ~ 2

Author(s):

Olga M. Sergeenko ◽

Konstantin A. Dyachkov ◽

Sergey O. Ryabykh ◽

Alexander V. Burtsev ◽

Alexander V. Gubin

Keyword(s):

Literature Review ◽

Case Reports ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Atlantoaxial Dislocation ◽

Os Odontoideum

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Mania and Down's Syndrome

The British Journal of Psychiatry ◽

10.1192/bjp.162.6.739 ◽

1993 ◽

Vol 162 (6) ◽

pp. 739-743 ◽

Cited By ~ 11

Author(s):

Sally-Ann Cooper ◽

Richard A. Collacott

Keyword(s):

Learning Disabilities ◽

Family History ◽

Affective Disorder ◽

Clinical Features ◽

Case Reports ◽

Down's Syndrome ◽

Down’S Syndrome ◽

Atypical Presentation ◽

Rapid Cycling ◽

History Of

Until recently, it was considered that Down's syndrome precluded a diagnosis of mania, or gave rise to an atypical presentation. There have been seven case reports of mania in people with Down's syndrome and all these cases are reviewed. The clinical features of mania are noted to be similar to those previously described in individuals with learning disabilities due to other causes. However, all reported cases are male and none has a family history of affective disorder. In two of the seven men reported, the illness followed a rapid cycling pattern. Hypothyroidism and monoamine biochemistry in people with Down's syndrome are discussed in the context of these atypical features.

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Aplastic Anemia in Down's Syndrome

PEDIATRICS ◽

10.1542/peds.67.6.896 ◽

1981 ◽

Vol 67 (6) ◽

pp. 896-897

Author(s):

Mark E. Weinblatt ◽

Gussie Higgins ◽

Jorge A. Ortega

Keyword(s):

Bone Marrow ◽

Aplastic Anemia ◽

Down's Syndrome ◽

Down’S Syndrome

A child with Down's syndrome was seen with pancytopenia and was found to have an aplastic bone marrow. None of the known contributing etiologies of aplastic anemia could be identified in this patient. This is the first reported case of the simultaneous appearance of these two disorders.

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