Detection of Bovine Leukocyte Adhesion Deficiency (BLAD) in Turkish native and Holstein cattle

2006 ◽  
Vol 54 (2) ◽  
pp. 173-178 ◽  
Author(s):  
B. Akyüz ◽  
O. Ertu?rul
Keyword(s):  
Leukocyte Adhesion ◽  
Holstein Cattle ◽  
Leukocyte Adhesion Deficiency

scholarly journals PCR screening and allele frequency estimation of bovine leukocyte adhesion deficiency in Holstein and Gir cattle in Brazil

2000 ◽  
Vol 23 (4) ◽  
pp. 831-834 ◽  
Author(s):  
Luciana A. Ribeiro ◽  
Erica E. Baron ◽  
Mário L. Martinez ◽  
Luiz L. Coutinho
Keyword(s):  
Mutant Allele ◽  
Leukocyte Adhesion ◽  
Frequency Estimation ◽  
Low Frequency ◽  
Cattle Breed ◽  
Holstein Cattle ◽  
Leukocyte Adhesion Deficiency ◽  
Pcr Screening ◽  
The World ◽  
Dairy Bulls

Bovine leukocyte adhesion deficiency (BLAD) is a disease known to affect the Holstein cattle breed throughout the world. Eighty-eight Holstein dairy cows and 88 Gir dairy bulls were genotyped by PCR for the CD18 BLAD alelle. The frequency of the BLAD mutant allele and the BLAD-carrier prevalence in Brazilian Holstein cows were 2.8 and 5.7%, respectively. No mutant allele was found in any of the 88 Gir animals. We conclude that the CD18 gene mutation is prevalent in Brazilian Holstein cattle and absent or present at a very low frequency in Gir cattle.

Alimentary and Respiratory Tract Lesions in Eight Medically Fragile Holstein Cattle with Bovine Leukocyte Adhesion Deficiency (BLAD)

1996 ◽  
Vol 33 (3) ◽  
pp. 273-281 ◽  
Author(s):  
M. R. Ackermann ◽  
M. E. Kehrli ◽  
J. A. Laufer ◽  
L. T. Nusz
Keyword(s):  
Respiratory Tract ◽  
Medical Care ◽  
Leukocyte Adhesion ◽  
Viral Disease ◽  
Restriction Endonuclease Analysis ◽  
Intestinal Lumen ◽  
Holstein Cattle ◽  
Leukocyte Adhesion Deficiency ◽  
Medically Fragile ◽  
Partially Occluded

Lesions in the alimentary tract were studied in eight medically fragile Holstein cattle homozygous for the bovine leukocyte adhesion deficiency (BLAD) allele as determined by polymerase chain reaction and restriction endonuclease analysis. These cattle received institutional medical care but died or were euthanatized because of chronic debilitation associated with diarrhea (6/8) and pneumonia (4/8). The six cattle with diarrhea had acute ( n = 3) or chronic ( n = 3) intestinal ulcers, but the other two remained relatively healthy for 3 years and did not develop intestinal tract ulcers. Ulcerated areas were present in the small intestine in six animals, and two of these also had ulcers in the large intestine. Ulcers were covered by thick exudates that, in chronic lesions, partially occluded the intestinal lumen. Intramural and serosal fibrosis also contributed to lumen constriction. Pseudomonas aeruginosa was isolated from the intestine of four cattle. Bovine viral disease virus and Salmonella were not isolated from the five cattle that were tested. Respiratory tract lesions consisted of dense infiltrates of neutrophils in bronchi, bronchioles, and alveoli. This study suggests that intestinal lesions are integral to the demise of BLAD cattle that receive intensive medical care and that neutrophils do infiltrate the lung and enter airway lumina, despite the adhesion deficiency.

Sign in / Sign up

Export Citation Format

Share Document