scholarly journals Modern pharmacological therapy of breast cancer

2012 ◽  
Vol 153 (2) ◽  
pp. 56-65 ◽  
Author(s):  
István Láng ◽  
Zsuzsanna Kahán ◽  
Erika Hitre ◽  
Magdolna Dank ◽  
Gábor Rubovszky ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Healthy Lifestyle ◽  
Treatment Plan ◽  
Breast Cancer Mortality ◽  
Screening Mammography ◽  
Pharmacological Therapy ◽  
Oncological Treatment ◽  
Biological Features ◽  
Therapy Strategy ◽  
Definitive Therapy

Healthy lifestyle, population-based screening mammography and modern medical-oncological treatment in specialized breast cancer centers are the basic elements of the fight against breast cancer mortality. Treatment plan for the individual patient should be recommended by multidisciplinary oncoteam before initiating definitive therapy. Strategy of the medical-oncological therapy of breast cancer is determined by the biological features and stage of the tumor. The most important biological features are endocrine sensitivity, Human Epidermal Growth Factor Receptor 2 status and proliferative capability of the tumor. In this review the strategy of medical-oncological treatment (chemotherapy, endocrine therapy, targeted biological therapy) of breast cancer is presented, based on receptor status and proliferative capability of the tumor in various stages of the disease. Orv. Hetil., 2012, 153, 56–65.

Continuation of Annual Screening Mammography and Breast Cancer Mortality in Women Older Than 70 Years

2020 ◽  
Vol 172 (6) ◽  
pp. 381 ◽  
Author(s):  
Xabier García-Albéniz ◽  
Miguel A. Hernán ◽  
Roger W. Logan ◽  
Mary Price ◽  
Katrina Armstrong ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Screening Mammography ◽  
Annual Screening

scholarly journals Psychological Aspects of Breast Reconstruction after Breast Cancer

Breast Care ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. 298-301
Author(s):  
Anna Pittermann ◽  
Christine Radtke
Keyword(s):  
Breast Cancer ◽  
Treatment Plan ◽  
Breast Cancer Mortality ◽  
Psychological Aspects ◽  
Breast Cancer Surgery ◽  
Psychosocial Needs ◽  
Reconstructive Procedures ◽  
Affected Woman ◽  
Close Family ◽  
Type Of Surgery

Even though breast cancer mortality is declining, the diagnosis still poses a huge threat for the affected woman and her close family. Breast cancer surgery, which often includes reconstructive procedures, can help restoring a satisfactory body image. The decision on the type of surgery should always be made together with the patient and should focus on her psychosocial needs. This review describes the psychological aspects of breast cancer for the patient and her social environment and offers ideas for a patient-oriented treatment plan.

scholarly journals Service screening mammography reduces breast cancer mortality among elderly women in Turku

2006 ◽  
Vol 13 (1) ◽  
pp. 34-40 ◽  
Author(s):  
I Parvinen ◽  
H Helenius ◽  
L Pylkkänen ◽  
A Anttila ◽  
P Immonen-Räihä ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Mortality ◽  
Elderly Women ◽  
Breast Cancer Mortality ◽  
Screening Mammography

scholarly journals Impact of screening mammography on breast cancer mortality

2015 ◽  
Vol 138 (8) ◽  
pp. 2003-2012 ◽  
Author(s):  
Archie Bleyer ◽  
Cornelia Baines ◽  
Anthony B. Miller
Keyword(s):  
Breast Cancer ◽  
Cancer Mortality ◽  
Breast Cancer Mortality ◽  
Screening Mammography

Original Paper: Contribution of clinical breast examination to mammography screening in the early detection of breast cancer

2003 ◽  
Vol 10 (1) ◽  
pp. 16-21 ◽  
Author(s):  
C Bancej ◽  
K Decker ◽  
A Chiarelli ◽  
M Harrison ◽  
D Turner ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Breast Cancer Mortality ◽  
Clinical Breast Examination ◽  
Screening Mammography ◽  
Detection Rates ◽  
Breast Examination ◽  
Mode Of Detection ◽  
Clinical Breast ◽  
Interim Measures

Objectives: As the benefit of clinical breast examination (CBE) over that of screening mammography alone in reducing breast cancer mortality is uncertain, it is informative to monitor its contribution to interim measures of effectiveness of a screening programme. Here, the contribution of CBE to screening mammography in the early detection of breast cancer was evaluated. Setting: Four Canadian organised breast cancer screening programmes. Methods: Women aged 50-69 receiving dual screening (CBE and mammography) (n=300,303) between 1996 and 1998 were followed up between screen and diagnosis. Outcomes assessed by mode of detection (CBE alone, mammography alone, or both CBE and mammography) included referral rate, positive predictive value, pathological features of tumours (size, nodal status, morphology), and cancer detection rates overall and for small cancers (≤10 mm or node-negative). Heterogeneity in findings across programmes was also assessed. Results: On first versus subsequent screen, CBE alone resulted in 28.5-36.7% of referrals, and 4.6-5.9% of cancers compared with 52.6-60.1% of referrals and 60.0-64.3% of cancers for mammography alone. Among cancers detected by CBE, 83.6-88.6% were also detected by mammography, whereas for mammographically detected cancers only 31.7-37.2% were also detected by CBE. On average, CBE increased the rate of detection of small invasive cancers by 2-6% over rates if mammography was the sole detection method. Without CBE, programmes would be missing three cancers for every 10,000 screens and 3-10 small invasive cancers in every 100,000 screens. Conclusions: Inclusion of CBE in an organised programme contributes minimally to early detection.

The effect of mammography screening regimen on incidence-based breast cancer mortality

2018 ◽  
Vol 25 (4) ◽  
pp. 197-204 ◽  
Author(s):  
Martin J Yaffe ◽  
Nicole Mittmann ◽  
Oguzhan Alagoz ◽  
Amy Trentham-Dietz ◽  
Anna NA Tosteson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Mortality ◽  
Breast Cancer Incidence ◽  
Temporal Distribution ◽  
Screening Mammography ◽  
Breast Cancers ◽  
Breast Cancer Death ◽  
Life Years ◽  
Life Years Lost ◽  
The Mean

Objectives Incidence-based mortality quantifies the distribution of cancer deaths and life-years lost, according to age at detection. We investigated the temporal distribution of the disease burden, and the effect of starting and stopping ages and interval between screening mammography examinations, on incidence-based mortality. Methods Incidence-based mortality was estimated using an established breast cancer simulation model, adapted and validated to simulate breast cancer incidence, screening performance, and delivery of therapies in Canada. Ten strategies were examined, with varying starting age (40 or 50), stopping age (69 or 74), and interval (1, 2, 3 years), and “No Screening.” Life-years lost were computed as the difference between model predicted time of breast cancer death and that estimated from life tables. Results Without screening, 70% of the burden in terms of breast cancer deaths extends between ages 45 and 75. The mean of the distribution of ages of detection of breast cancers that will be fatal in an unscreened population is 61.8 years, while the mean age of detection weighted by the number of life-years lost is 55, a downward shift of 6.8 years. Similarly, the mean age of detection for the distribution of life-years gained through screening is lower than that for breast cancer deaths averted. Conclusion Incidence-based mortality predictions from modeling elucidate the age dependence of the breast cancer burden and can provide guidance for optimizing the timing of screening regimens to achieve maximal impact. Of the regimens studied, the greatest lifesaving effect was achieved with annual screening beginning at age 40.

scholarly journals Breast cancer mortality and screening mammography in New Zealand: Incidence-based and aggregate analyses

2018 ◽  
Vol 26 (1) ◽  
pp. 35-43 ◽  
Author(s):  
Richard Taylor ◽  
Marli Gregory ◽  
Kerry Sexton ◽  
Jessica Wharton ◽  
Nisha Sharma ◽  
...  
Keyword(s):  
Breast Cancer ◽  
New Zealand ◽  
Cancer Mortality ◽  
Mammography Screening ◽  
Breast Cancer Mortality ◽  
Primary Treatment ◽  
Screening Mammography ◽  
Randomized Controlled ◽  
Before And After ◽  
Incident Cases

Objective To investigate trends in breast cancer mortality in New Zealand women, to corroborate or negate a causal association with service screening mammography. Method Cumulated mortality rates from breast cancer deaths individually linked to incident cases diagnosed before and after screening commencement were compared, in women aged 50–64 (from 2001) and aged 45–49 and 65–69 (from 2006). Trends and differences in aggregate invasive breast cancer mortality (1975–2013) were assessed in relation to introduction of mammography screening targeting women aged 50–64 and 45–69. Joinpoint analysis was also undertaken. Results The reduction in incidence-based cumulated breast cancer mortality before and after the introduction of screening was −15% (p = 0.006) for women aged 45–69, and 17% (p = 0.005) for those aged 50–64. Aggregate mortality declined by −34% (2005–13 compared with 1992–98) in the age group 50–64, and by –28% among women aged 45–49 and –25% among women aged 65–74. For women aged 50–64 the 2-joinpoint model shows a 1990 turning point, from prior rising mortality to a mean −1.8% decline per annum, coinciding with improvements in primary treatment of breast cancer; and a steepening of the decline (−3.0% p.a.) from the late 1990s, coinciding with the introduction of service mammography screening. Conclusion Breast cancer mortality declines occurring since the advent of screening mammography in New Zealand are consistent with other incidence-based and aggregate studies of screening mammography in populations, individual-based cohort studies, and randomized controlled trials.

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