Food tolerance аormation to cow's milk proteins in children with acute manifestations of food allergy to cow's milk proteins

Identification of offending allergens in patients with food allergy is a very important part of an allergist’s activity. Objective. To study the structure оf sensitization to food allergens among children in Moscow and Moscow region and to determine the significance of sensitization to milk proteins . Methods. The level and class of specific IgE in blood serum of children with IgEmediated allergic diseases were examined with RIDA AllergyScreen method. Serum of children with high level of specific IgE to milk allergenic proteins was studied. The level and ratio of specific IgE to individual milk allergens were revealed. Results. The structure of sensitization to food allergens was determined. It was revealed that cow’s milk allergens are the leading triggers of food allergy, especially in early childhood in Moscow and the Moscow region. The features of sensitization to cow’s milk proteins among children were analyzed. Conclusions. According to the study, about half of children with IgEmediated food allergies in Moscow and the Moscow region have sensitization to cow’s milk proteins. The leading role in the frequency of sensitization belongs to whey proteins of milk. Among them sensitization to а-lactalbumin was detected more often. The questions about the selection of hypoallergenic milk formulas for feeding of children with allergy to cow’s milk proteins were discussed.

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Food Allergy in Children with Inherited Epidermolysis Bullosa. The Results of the Observational Study

Annals of the Russian academy of medical sciences ◽

10.15690/vramn847 ◽

2018 ◽

Vol 73 (1) ◽

pp. 49-58 ◽

Cited By ~ 1

Author(s):

S. G. Makarova ◽

L. S. Namazova-Baranova ◽

N. N. Murashkin ◽

E. A. Vishneva ◽

R. V. Epishev ◽

...

Keyword(s):

Food Allergy ◽

Epidermolysis Bullosa ◽

Simple Form ◽

Clinical Manifestations ◽

Milk Proteins ◽

Cow’S Milk ◽

Serum Ige ◽

Cow's Milk ◽

Inherited Epidermolysis Bullosa ◽

Cow’S Milk Proteins

Background: Inherited epidermolysis bullosa (EB) refers to a group of rare inherited disorders characterized by severe damage of skin and in most patients — the gastrointestinal mucosa, what leads to a violation of skin and mucosal barrier properties in relation to allergens. However, the issues of food sensitization and food allergy in this category of patients have not been studied, and the study of this problem is important.Aim: To evaluate the clinical manifestations of food allergy (FA) and IgE-response to food proteins in children with EB.Methods: 82 patients with EB aged from 2 months to 16 years were entered this open non-randomized observational prospective study, including 20 patients with simple form of EB and 62 patients with dystrophic form of EB. We analyzed allergic history and clinical manifestations of the FA in all the patients. Every patient in this study underwent of determination of the concentration of total serum IgE and specific serum IgE to the most important food allergens, as well as to mixtures of household allergens in some cases (UniCAP System, Phadia AB). Results: Skin lesion in patients with EB masks allergic skin manifestations, causing a hypodiagnosis of the FA in this category of patients, which in turn leads to erroneous organization of nutritional support. FA (clinical manifestations) was identified in 20.7% of children with EB (in 10% of cases with simple form of EB and in 24.2% — in patients with dystrophic form of EB). Products containing cow’s milk protein, cereals, and eggs were identified as etiologic factors of FA in most cases. In the group of children with comorbidity FA and EB high and very high levels of total IgE (1000 kUA / l) were detected most frequently. The main cause-significant allergens are cow’s milk proteins, cereals, eggs. Conclusions: Comorbidity with FA is high in patients with dystrophic form of EB. The main cause-significant allergens are cow’s milk proteins, cereals, eggs.

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Food allergy and the potential allergenicity-antigenicity of microparticulated egg and cow's milk proteins.

Journal of the American College of Nutrition ◽

10.1080/07315724.1990.10720399 ◽

1990 ◽

Vol 9 (4) ◽

pp. 410-417 ◽

Cited By ~ 15

Author(s):

H A Sampson ◽

S K Cooke

Keyword(s):

Food Allergy ◽

Milk Proteins ◽

Cow’S Milk ◽

Cow's Milk ◽

Cow’S Milk Proteins

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Active formation of tolerance in case of allergy to cow's milk proteins

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja1491 ◽

2021 ◽

Author(s):

Albina Galimova ◽

Svetlana Vyazankina ◽

Svetlana Makarova ◽

Oksana Ereshko

Keyword(s):

Food Allergy ◽

Milk Proteins ◽

Oral Immunotherapy ◽

Food Allergies ◽

Cow’S Milk ◽

Cow's Milk ◽

Form Tolerance ◽

Threatening Condition ◽

Life Threatening ◽

Cow’S Milk Proteins

Food allergy is a potentially life-threatening condition in which there are no approved pathogenetic treatments other than elimination of the causal allergen and relief of acute allergic conditions. IgE- mediated form of food allergy remains a serious and growing problem worldwide. Its prevalence is steadily increasing, and is a severe psychosocial and economic burden for patients and their families. Cow's milk and products based on it are important components of a child's diet, which are introduced into the diet of children of the first year of life, but can cause allergic reactions. The traditional management of children with cow's milk allergy consists in prescribing an elimination dairy-free diet and a significant part of patients form tolerance to milk proteins by the age of 5 years. However, with persistent forms of allergy to cows milk proteins, the question is raised about the need for "active" tactics of patient management in order to form tolerance. Oral immunotherapy is a promising approach to the treatment of food allergies based on a gradual increase in the allergen taken, by analogy with standardized immunotherapy for respiratory allergens, until a maintenance dose is reached. Each stage of oral immunotherapy should be considered as a personalized therapy. This review contains an analysis of available studies on the effectiveness of oral immunotherapy in the treatment of allergy to cow's milk proteins.

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Faculty Opinions recommendation of Contribution of IgE and immunoglobulin free light chain in the allergic reaction to cow's milk proteins.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717971166.793469473 ◽

2013 ◽

Author(s):

Rob Stockley

Keyword(s):

Allergic Reaction ◽

Light Chain ◽

Milk Proteins ◽

Free Light Chain ◽

Cow’S Milk ◽

Cow's Milk ◽

Cow’S Milk Proteins

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Soy Formula Doesn't Help Colic

PEDIATRICS ◽

10.1542/peds.71.2.299b ◽

1983 ◽

Vol 71 (2) ◽

pp. 299-300

Author(s):

LASSE LOTHE ◽

TOR LINDBERG ◽

IRÉNE JAKOBSSON

Keyword(s):

Adverse Reaction ◽

Soy Protein ◽

Milk Proteins ◽

Cow’S Milk ◽

Milk Formula ◽

Cow's Milk ◽

Cow’S Milk Proteins

In Reply.— We fully agree with LeBlanc that there was no significant improvement when infants with colic were given a soy protein-based formula. As pointed out in the "Discussion," as many as 53% of the infants showed an adverse reaction to soy (corresponding figure for cow's milk formula was 71%). We also emphasized that these figures must be interpreted with caution. In fact, soy protein-based formula was a bad choice as placebo. A placebo substance should be a substance of no importance as an allergen in infancy and soy protein has been shown to be as antigenic as cow's milk proteins (Eastham EJ, et al: J Pediatr 1978;93:561).

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ЕФЕКТИВНІСТЬ ЕЛІМІНАЦІЙНОЇ ДІЄТИ У ДІТЕЙ ГРУДНОГО ВІКУ З ГАСТРОІНТЕСТИНАЛЬНИМИ ПРОЯВАМИ ХАРЧОВОЇ АЛЕРГІЇ

INTERNATIONAL ACADEMY JOURNAL Web of Scholar ◽

10.31435/rsglobal_wos/31052019/6500 ◽

2019 ◽

pp. 16-21

Author(s):

Гайдучик Г. А.

Keyword(s):

Milk Proteins ◽

Diet Therapy ◽

Elimination Diet ◽

Cow’S Milk ◽

Complete Regression ◽

Cationic Protein ◽

Cow's Milk ◽

Skin Symptoms ◽

Gastrointestinal Food Allergy ◽

Cow’S Milk Proteins

The purpose of the work was to evaluate the effectiveness of the elimination diet in infants with gastrointestinal manifestations of food allergy.Patients and methods. 84 children aged 2 months to 1 year were examined with gastrointestinal food allergy to cow's milk proteins. All children were prescribed an elimination diet with the exclusion of cow's milk proteins. An assessment was made of the regression of gastrointestinal symptoms on day 3, 7 and 14 of diet therapy and the determination of the concentration of eosinophilic cationic protein in serum. The general-clinical, immunological, allergological and statistical methods of research were used.Results. The purpose of the elimination diet with the exclusion of cow's milk proteins for nursing mothers and the use of mixtures with extensive hydrolysis of protein in the case of artificial feeding leads to a complete regression of gastrointestinal and skin symptoms in all examined children on the 14th day of diet therapy, which is further confirmed by the normalization of the concentration of eosinophilic cationic serum protein in diet therapy. Conclusions. Elimination of cow's milk proteins in infants with gastrointestinal food allergy results in complete regression of gastrointestinal and skin symptoms on day 14 of diet therapy, and determination of the concentration of eosinophilic cationic protein in serum can be used as an additional criterion for the effectiveness of diet therapy.

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