Objective: To explore the mediating role of emotional lability in the relationship between adult ADHD symptoms, and cannabis and alcohol consumption.Method: Emotional lability and concurrent cannabis and alcohol consumption were measured as part of the ecological momentary assessment study, ‘Decades to Minutes’; embedded within the longitudinal z-proso study. Adults (n = 289, aged 20) completed measures of concurrent alcohol and cannabis consumption, and emotional lability at four quasi-random time periods per day, over a 14-day period. ADHD symptoms were retrieved from the participants’ corresponding z-proso data. Results: Structural equation modelling revealed that ADHD symptoms, but not emotional lability, had a direct effect on concurrent cannabis use. Contrastingly, emotional lability, but not ADHD symptoms, had a direct effect on concurrent alcohol use. Conclusion: Results highlight the differing effects of emotional lability in the association between ADHD symptoms and different types of substance use. Clinical implications of these findings are discussed.