Role of α2-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis

The lateral parabrachial nucleus (LPBN) has been shown to be anatomically linked to a number of forebrain nuclei and medullary structures implicated in the control of body fluid balance and cardiovascular regulation. Although these connections suggest a role for the LPBN in body fluid homeostasis, there is currently little or no physiological or behavioral data to support this notion. The purpose of the present series of experiments was to determine the importance of the ventrolateral region of the LPBN (VLLPBN) in the behavioral response to various thirst challenges. Rats with electrolytic lesions of the VLLPBN and control rats were studied after administration of angiotensin II (ANG II) (1.5 and 3.0 mg/kg), isoproterenol (30 and 100 micrograms/kg), polyethylene glycol (20%) and hypertonic saline (4 and 12%). It was found that rats with lesions drank more in response to ANG II and isoproterenol administration than did control animals.

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Role of interleukin 1β in the integrative mechanisms and the maintenance of body fluid homeostasis in conscious rats

Pathophysiology ◽

10.1016/0928-4680(94)90727-7 ◽

1994 ◽

Vol 1 ◽

pp. 355 ◽

Cited By ~ 1

Author(s):

H. Kannan ◽

K. Iki ◽

T. Kunitake ◽

K. Hirota ◽

T. Hanamori ◽

...

Keyword(s):

Body Fluid ◽

Interleukin 1Β ◽

Conscious Rats ◽

Fluid Homeostasis ◽

Body Fluid Homeostasis

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Role of Forebrain TRPV1 Receptors in Body Fluid Homeostasis

The FASEB Journal ◽

10.1096/fasebj.22.1_supplement.738.1 ◽

2008 ◽

Vol 22 (S1) ◽

Author(s):

Anna Caitlynn Taylor ◽

John J McCarthy ◽

Sean D Stocker

Keyword(s):

Body Fluid ◽

Fluid Homeostasis ◽

Trpv1 Receptors ◽

Body Fluid Homeostasis

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ROLE OF SODIUM IN CEREBRAL CONTROL OF BODY FLUID HOMEOSTASIS

Kidney and Body Fluids ◽

10.1016/b978-0-08-026824-8.50085-0 ◽

1981 ◽

pp. 601-609

Author(s):

B. Andersson ◽

L.G. Leksell ◽

K. Olsson

Keyword(s):

Body Fluid ◽

Fluid Homeostasis ◽

Cerebral Control ◽

Body Fluid Homeostasis

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Corticotropin-releasing hormone in the lateral parabrachial nucleus inhibits sodium appetite in rats

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00075.2003 ◽

2006 ◽

Vol 290 (4) ◽

pp. R1136-R1141 ◽

Cited By ~ 31

Author(s):

Emilio De Castro e Silva ◽

Josmara B. Fregoneze ◽

Alan Kim Johnson

Keyword(s):

Sodium Chloride ◽

Body Fluid ◽

Behavioral Control ◽

Parabrachial Nucleus ◽

Salt Appetite ◽

Corticotropin Releasing Hormone ◽

Releasing Hormone ◽

Sodium Appetite ◽

Lateral Parabrachial Nucleus ◽

Body Fluid Homeostasis

The present study investigated the role of corticotropin-releasing hormone (CRH) in the lateral parabrachial nucleus (LPBN) in the behavioral control of body fluid homeostasis by determining the effect of bilateral injections of the CRH receptor antagonist, α-helical corticotropin-releasing factor (CRF)9–41, and the CRH receptor agonist, CRH, on sodium chloride (salt appetite) and water (thirst) intake. Groups of adult, male Sprague-Dawley rats had stainless-steel cannulas implanted bilaterally into the LPBN and were sodium depleted or water deprived. Bilateral injections of α-helical CRF9–41 into the LPBN significantly potentiated water and salt intake in the sodium-depleted rats when access to fluids was restored. Bilateral injections of α-helical CRF9–41 into the LPBN (1.0 μg) also increased sodium appetite in water-deprived rats. Conversely, in sodium-depleted animals, bilateral injections of CRH inhibited sodium chloride intake. These results suggest that there is an endogenous CRH inhibitory mechanism operating in the LPBN to modulate the intake of sodium (salt appetite). This mechanism may contribute to the behavioral control of restoration of body fluid homeostasis in sodium-deficient states.

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