scholarly journals Schwannomas in the head and neck: retrospective analysis of 21 patients and review of the literature

2007 ◽  
Vol 125 (4) ◽  
pp. 220-222 ◽  
Author(s):  
Erwin Langner ◽  
André Del Negro ◽  
Hugo Kenzo Akashi ◽  
Priscila Pereira Costa Araújo ◽  
Alfio José Tincani ◽  
...  
Keyword(s):  
Head And Neck ◽  
Schwann Cells ◽  
Neck Region ◽  
Diagnostic Methods ◽  
Von Recklinghausen’S Disease ◽  
Von Recklinghausen's Disease ◽  
Head And Neck Region ◽  
Tumor Enucleation ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

CONTEXT AND OBJECTIVE: Schwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells. According to their cellularity, they can be subdivided into Antoni A or Antoni B types. They are rare and usually solitary, with clearly delimited capsules. They occur in the head and neck region in only 25% of the cases, and may be associated with Von Recklinghausen's disease. The present study retrospectively analyzed some data on this disease in the head and neck region and reviewed the literature on the subject. DESIGN AND SETTING: Retrospective study at Head and Neck Service, Universidade Estadual de Campinas. METHODS: Data on 21 patients between 1980 and 2003 were reviewed. The sites of cervical schwannomas and the intraoperative, histopathological and postoperative clinical status of these cases were studied. Diagnostic methods, type of surgery and association with neurofibromatosis were evaluated. RESULTS: The patients' ages ranged from 16 to 72 years. Four patients had a positive past history of type I neurofibromatosis or Von Recklinghausen's disease. The nerves affected included the brachial and cervical plexuses, vagus nerve, sympathetic chain and lingual or recurrent laryngeal nerve. The nerve of origin was not identified in six cases. Tumor enucleation was performed in 16 patients; the other five required more extensive surgery. CONCLUSION: Schwannomas and neurofibromas both derive from Schwann cells, but are different entities. They are solitary lesions, except in Von Recklinghausen's disease. They are generally benign, and rarely recur. The recommended surgical treatment is tumor enucleation.

Skeletal lesions in von Recklinghausen's disease of the head and neck in Nigerian Africans

1986 ◽  
Vol 100 (7) ◽  
pp. 823-830 ◽  
Author(s):  
G. T. A. Ijaduola ◽  
S. A. Ademiluyi ◽  
D. A. Olarenwaju
Keyword(s):  
Head And Neck ◽  
Parietal Bone ◽  
University Teaching ◽  
Von Recklinghausen’S Disease ◽  
Heterotopic Bone ◽  
Heterotopic Bone Formation ◽  
Von Recklinghausen's Disease ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease ◽  
Skeletal Lesions

SummaryA study of skeletal lesions in the head and neck region of 20 adult patients with von Recklinghausen's disease, seen in the Surgical Out Patient clinic of Lagos University Teaching Hospital from 1979 to 1985, has been carried out. Among the 20 patients, 13 (65 per cent) had symptoms related to the head and neck while 7 (37 per cent) did not; however, on radiological screening, all of them were observed to have skeletal lesions. The commonest feature was enlarged intervertebral nerve root exit foramina from mesodermal dysplasia, which occurred in 16 (80 per cent) of our patients. Other major findings were erosion of the mandible, 8 (40 per cent); erosion of the wings of the sphenoid, 4 (20 per cent); poor mastoid bone pneu-matisation, 3 (15 per cent); erosion of the parietal bone, 3 (15 per cent) and heterotopic bone formation, 1 (5 per cent). Congenital calvarial defects were not detected. In view of the fact that all our patients showed radiologically detectable skeletal lesions of the head and neck, despite absence of symptoms in 35 per cent, it is advisable that all patients with von Recklinghausen's disease should routinely have radiological screening of this region, to detect early lesions.

Which cells are inducer or target of neurofibromas in von Recklinghausen's disease?

1986 ◽  
Vol 48 (3) ◽  
pp. 491-499
Author(s):  
Shuhei IMAYAMA ◽  
Yutaka YASHIMA ◽  
Atsushi IRIKI ◽  
Emiko SATO ◽  
Harukuni URABE
Keyword(s):  
Von Recklinghausen’S Disease ◽  
Von Recklinghausen's Disease ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

Concurrence of Marfan's syndrome and von Recklinghausen's disease with the development of malignant schwannoma.

1987 ◽  
Vol 49 (3) ◽  
pp. 460-464
Author(s):  
Kazumoto KATAGIRI ◽  
Tomohito HONDA ◽  
Satoshi ITAMI ◽  
Etsuji MATSUNAGA ◽  
Hiroshi SHINKAI ◽  
...  
Keyword(s):  
Malignant Schwannoma ◽  
Von Recklinghausen’S Disease ◽  
Marfan’S Syndrome ◽  
Von Recklinghausen's Disease ◽  
Marfan's Syndrome ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

Neural sheath tumors of major nerves

1994 ◽  
Vol 81 (3) ◽  
pp. 362-373 ◽  
Author(s):  
Thomas R. Donner ◽  
Rand M. Voorhies ◽  
David G. Kline
Keyword(s):  
Motor Function ◽  
Complete Resolution ◽  
Von Recklinghausen’S Disease ◽  
Total Removal ◽  
Von Recklinghausen's Disease ◽  
Plexiform Neurofibromas ◽  
Pain Syndromes ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

✓ Over a 22-year period, operations were performed on 263 patients for 288 primary benign tumors of major peripheral nerves. The tumors included 85 schwannomas, 197 neurofibromas, and six plexiform neurofibromas. Total removal was achieved in 83 of the 85 schwannomas, and 76 of these patients were available for follow-up evaluation. Motor function either improved or was unchanged in 87% of these patients and 85% of those with pain in the distribution of the involved nerve had either total or partial resolution of their symptoms. Of the neurofibromas, 123 occurred in 121 patients without von Recklinghausen's disease. All tumors within this group were completely excised using a fascicular approach to the tumor. Of the 99 patients available for follow-up evaluation, 90% had either improved or unchanged motor function and 88% had partial or complete resolution of pain syndromes. Fifty-nine patients with von Recklinghausen's disease had 80 tumors removed: 74 fusiform tumors (58 of which were completely removed) and six plexiform tumors. Forty-eight of the 58 patients with gross total removal of fusiform tumors were available for follow-up evaluation, of whom 83% had improved or unchanged motor function and 74% had partial or complete resolution of pain syndromes. All six patients with plexiform tumors had progression of symptoms postoperatively. One brachial plexus schwannoma recurred and was re-excised without subsequent recurrence at the 5-year follow-up evaluation. Several incompletely excised plexiform neurofibromas have recurred with a symptomatic presentation.

NEUROFIBROMATA SIMULATING A PENIS AND LABIOSCROTAL GONADS IN A GIRL WITH VON RECKLINGHAUSEN'S DISEASE

PEDIATRICS ◽  
1966 ◽  
Vol 37 (3) ◽  
pp. 456-459
Author(s):  
Frederic M. Kenny ◽  
George H. Fetterman ◽  
Chawalit Preeyasombat
Keyword(s):  
Ambiguous Genitalia ◽  
Von Recklinghausen’S Disease ◽  
Von Recklinghausen's Disease ◽  
Histologic Diagnosis ◽  
Unilateral Ovariectomy ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

A 15-year-old girl is described, who had ambiguous genitalia from birth. Enlargement of the clitoris, and labioscrotal masses were present; these were shown to be due to unusually situated neurofibromata. This is the first reported instance of neurofibromata masquerading as a phallus and testes. Prior to the correct histologic diagnosis of the neurofibromata, she underwent two exploratory laparotomies, and unilateral ovariectomy in an attempt to explain the etiology of her ambiguous genitalia.

Primary hepatic somatostatinoma developed in a patient with von Recklinghausen's disease

2006 ◽  
Vol 41 (4) ◽  
pp. 389-391 ◽  
Author(s):  
Yoshihiko Morisawa ◽  
Atsushi Tanaka ◽  
Takatsugu Yamamoto ◽  
Satoko Uegaki ◽  
Yoriyuki Takamori ◽  
...  
Keyword(s):  
Von Recklinghausen’S Disease ◽  
Von Recklinghausen's Disease ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease
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