scholarly journals Kikuchi-Fujimoto disease: three case reports

2010 ◽  
Vol 128 (4) ◽  
pp. 232-235 ◽  
Author(s):  
Alexandre de Andrade Sousa ◽  
João Marcos Arantes Soares ◽  
Marco Homero de Sá Santos ◽  
Marcelo Portes Rocha Martins ◽  
José Maria Porcaro Salles
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Viral Infections ◽  
Case Reports ◽  
Excisional Biopsy ◽  
Review Of The Literature ◽  
Systemic Lupus ◽  
Specific Therapy

CONTEXT: Kikuchi-Fujimoto disease (KFD) manifests in most cases as unilateral cervical lymphadenomegaly, with or without accompanying fever. The disease mainly affects young women and has a self-limited course. It is more common in oriental countries, with few reports of its occurrence in Brazil. KFD should be included in the differential diagnosis of suspected cases of viral infections, tuberculosis, reactive lymphadenitis, systemic lupus erythematosus and metastatic diseases. It can be histologically confused with lymphoma. The disease is benign and self-limiting and an excisional biopsy of an affected lymph node is necessary for diagnosis. There is no specific therapy. CASE REPORTS: This study reports on three cases of non-Asian female patients with KFD who were attended at our service between 2003 and 2006. A review of the literature was carried out, with a systematic search on this topic, with the aim of informing physicians about this entity that is manifested by cervical masses and fever.

Appearance of systemic lupus erythematosus after thymectomy: four case reports and review of the literature

Lupus ◽  
1995 ◽  
Vol 4 (1) ◽  
pp. 33-37 ◽  
Author(s):  
Dror Mevorach ◽  
Serge Perrot ◽  
Neil MM Buchanan ◽  
Munther Khamashta ◽  
Sadek Laoussadi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Reports ◽  
Review Of The Literature ◽  
Systemic Lupus

scholarly journals Tubuloreticular Inclusions in the Absence of Systemic Lupus Erythematosus and HIV Infection: A Report of Three Pediatric Cases

2017 ◽  
Vol 7 (2) ◽  
pp. 91-101 ◽  
Author(s):  
Ayah Elmaghrabi ◽  
Elizabeth Brown ◽  
Ei Khin ◽  
Jared Hassler ◽  
Allen R. Hendricks
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Nephrotic Syndrome ◽  
Hiv Infection ◽  
Renal Biopsy ◽  
Lupus Erythematosus ◽  
Viral Infections ◽  
Case Reports ◽  
Systemic Lupus ◽  
Extensive Evaluation ◽  
Tubuloreticular Inclusions

Tubuloreticular inclusions (TRIs) are subcellular structures located within the cisternae of endoplasmic reticulum. Formation of TRIs has been linked to the exposure of excess interferon (IFN), either from endogenous or exogenous sources. In renal disease, TRIs have been most commonly associated with systemic lupus erythematosus (SLE), and human immunodeficiency virus-associated nephropathy (HIVAN). Case reports of patients with renal biopsies showing TRIs without underlying SLE or HIV are infrequent in adults, and to our knowledge none have been reported in children. We report 3 pediatric cases in which the renal biopsy showed TRIs on electron microscopy without underlying SLE or HIV infection. The first patient presented at 2 years of age with nephrotic syndrome and renal failure. His renal biopsy revealed focal segmental glomerulosclerosis and TRIs. The second patient presented at 6 months of age with infantile nephrotic syndrome, and his renal biopsy revealed membranous glomerulopathy and TRIs. The last patient presented at 4 years of age with acute kidney injury of unclear etiology leading to chronic kidney disease. Her biopsy revealed acute and chronic tubulointerstitial nephritis with TRIs. Despite extensive evaluation in all 3 patients, including testing for HIV infection and SLE, we could not identify an underlying etiology to explain the presence of TRIs. In conclusion, renal biopsy with TRIs in the absence of underling SLE and HIV remains obscure. We propose a possible role for excess IFN triggered by an abnormal immune response to common viral infections in the formation of TRIs and renal injury.

scholarly journals Autoimmune gastrointestinal complications in patients with systemic lupus erythematosus: case series and literature review

Lupus ◽  
2016 ◽  
Vol 25 (14) ◽  
pp. 1509-1519 ◽  
Author(s):  
S Custódio Alves ◽  
S Fasano ◽  
D A Isenberg
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Gastrointestinal Disease ◽  
Case Reports ◽  
Case Series ◽  
Review Of The Literature ◽  
Systemic Lupus ◽  
College Hospital ◽  
Gastrointestinal Complications ◽  
Systemic Lupus Erythematosus Case

The association of systemic lupus erythematosus (SLE) with gastrointestinal autoimmune diseases is rare, but has been described in the literature, mostly as case reports. However, some of these diseases may be very severe, thus a correct and early diagnosis with appropriate management are fundamental. We have analysed our data from the SLE patient cohort at University College Hospital London, established in 1978, identifying those patients with an associated autoimmune gastrointestinal disease. We have also undertaken a review of the literature describing the major autoimmune gastrointestinal pathologies which may be coincident with SLE, focusing on the incidence, clinical and laboratory (particularly antibody) findings, common aetiopathogenesis and complications.

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